31 research outputs found
Advanced LIGO's ability to detect apparent violations of the cosmic censorship conjecture and the no-hair theorem through compact binary coalescence detections
We study the ability of the advanced Laser Interferometer Gravitational-wave
Observatory (aLIGO) to detect apparent violations of the cosmic censorship
conjecture and the no-hair theorem. The cosmic censorship conjecture, which is
believed to be true in the theory of general relativity, limits the
spin-to-mass-squared ratio of a Kerr black hole. The no-hair theorem, which is
also believed to be true in the theory of general relativity, suggests a
particular value for the tidal Love number of a non-rotating black hole. Using
the Fisher matrix formalism, we examine the measurability of the spin and tidal
deformability of compact binary systems involving at least one putative black
hole. Using parameter measurement errors and correlations obtained from the
Fisher matrix, we determine the smallest detectable violation of bounds implied
by the cosmic censorship conjecture and the no-hair theorem. We examine the
effect of excluding unphysical areas of parameter space when determining the
smallest detectable apparent violations, and we examine the effect of different
post-Newtonian corrections to the amplitude of the compact binary coalescence
gravitational waveform. In addition, we perform a brief study of how the
recently calculated 3.0 pN and 3.5 pN spin-orbit corrections to the phase
affect spin and mass parameter measurability. We find that physical priors on
the symmetric mass ratio and higher harmonics in the gravitational waveform
could significantly affect the ability of aLIGO to investigate cosmic
censorship and the no-hair theorem for certain systems.Comment: 21 pages, 7 figures, 6 table
Aptamer-based multiplexed proteomic technology for biomarker discovery
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine
Tumornachsorge nach potentiell kurativer Resektion eines Karzinoms
Surveillance programs have been recommended for colorectal and breast cancer patients in several countries, and appropriate surveillance guidelines have been issued by various societies. The Swiss Society of Gastroenterology consensus paper recommends a surveillance program for patients after curative resection of colorectal cancer (CRC), and the respective guidelines are updated regularly. Early detection of recurrent disease from CRC allows treatment with intention to cure. Five year survival rates after treatment for recurrent CRC can reach up to 50 % or more. Therefore tumor surveillance in CRC is important, and there is compelling evidence that patients benefit from intensive surveillance. In addition to clinical controls, measurements of carcinoembryonal antigen, colonoscopies and thoraco-abdominal CT scans should be performed on a regular basis. For surveillance of breast cancer (BC) patients, a regular schedule is recommended as well. However, this surveillance program is more focussing on the detection of possible loco-regional tumor relapse, as curative therapy of BC metastases is much less frequently possible than in CRC patients. Irrespective of the underlying tumor entity, surveillance is an important and challenging process that should be coordinated by one single physician. It is crucial that all involved physicians are aware of their responsibility and that they are informed about the respective surveillance program and its benefit to the patient
Sentinel lymph node procedure leads to upstaging of patients with resectable colon cancer: results of the Swiss prospective, multicenter study sentinel lymph node procedure in colon cancer
The value of the sentinel lymph node (SLN) procedure in colon cancer patients remains a matter of debate. The objective of this prospective, multicenter trial was 3-fold: to determine the identification rate and accuracy of the SLN procedure in patients with resectable colon cancer; to evaluate the learning curve of the SLN procedure; and to assess the extent of upstaging due to the SLN procedure
Results of the Blalock-Hanlon operation in 90 patients with transposition of the great vessels
Music Therapy Advances in Neuro-disability - Innovations in Research and Practice:Summary Report and Reflections on a Two-Day International Conference
This article provides a summary of the oral papers presented during a two day international conference, which took place on 7th & 8th June 2013, at the Royal Hospital for Neuro-disability (RHN) in London. The summary texts detail innovative research projects and clinical developments across music therapy, music neuroscience and music psychology addressing the needs of those with acquired and degenerative neurological conditions. The diverse and evolving work in this field is reflected in the topics covered, including disorders of consciousness, dementia, stroke, and the use of modern neuro-imaging methods to measure the effects of music therapy at a cortical level. A discussion of the implications of these converging foci highlights the benefits of the cross-disciplinary dialogue that characterised the conference