Sermano – Sant’Agustinu

C’est à la suite d’une prospection sur le piton rocheux de Sant’Agustinu où furent observées les arases d’une structure quadrangulaire non répertoriée, qu’un sondage fut réalisé en juin 1994. Les travaux ont permis de reconnaître les fondations d’une tour carrée dont la superficie intérieure couvre environ 12 m2. La largeur des murs atteint en moyenne 1 m. Ils sont parementés de moellons taillés sur une face, jointoyés à la chaux avec un blocage interne de pierres polygonales liées par de la ..

Estudio Fenomenológico De Un Modelo 331 Interfamilia, Sin Cargas Eléctricas Exóticas

Se realiza el estudio fenomenológico de un modelo 331 interfamilia sin cargas eléctricas exótica. Dentro del estudio se encuentra el sector escalar que permite, de la manera más económica, el rompimiento espontaneo de la simetrı́a gauge para que los bosones y fermiones presentes adquieran masa. Por otro lado, las corrientes, tanto neutras como cargadas, para el contenido fermiónico son calculadas, ası́ como también los acoples para los procesos $Z^\mu_1 \rightarrow \bar{f}f$, $Z^\mu_2 \rightarrow \bar{f}f$

Widespread Genotype-Phenotype Correlations in Intellectual Disability

Background: Linking genotype to phenotype is a major aim of genetics research, yet the underlying biochemical mechanisms of many complex conditions continue to remain elusive. Recent research provides evidence that relevant gene-phenotype associations are discoverable in the study of intellectual disability (ID). Here we expand on that work, identifying distinctive gene interaction modules with unique enrichment patterns reflective of associated clinical features in ID.Methods: Two hundred twelve forms of monogenic ID were curated according to comorbidities with autism and epilepsy. These groups were further subdivided according to secondary clinical manifestations of complex vs. simple facial dysmorphia and neurodegenerative-like features due to their clinical prominence, modest symptom overlap, and probable etiological divergence. An aggregate gene interaction ID network for these phenotype subgroups was discovered via a public database of known gene interactions: protein-protein, genetic, and mRNA coexpression. Additional annotation resources (Gene Ontology, Human Phenotype Ontology, TRANSFAC/JASPAR, and KEGG/WikiPathways) were utilized to assess functional and phenotypic enrichment patterns within subgroups.Results: Phenotypic analysis revealed high rates of complex facial dysmorphia in ID with comorbid autism. In contrast, neurodegenerative-like features were overrepresented in ID with epilepsy. Network analysis subsequently showed that gene groups divided according to clinical features of interest resulted in distinctive interaction clusters, with unique functional enrichments according to gene set.Conclusions: These data suggest that specific comorbid and secondary clinical features in ID are predictive of underlying genotype. In summary, ID form unique clusters, which are comprised of individual conditions with remarkable genotypic and phenotypic overlap

Caracterización metalográfica y evaluación de las propiedades mecánicas de los aceros con y sin nitruración AISI 4340 y 34CRNIMO6, para la Empresa SERTECPET S.A.

El objetivo de este estudio fue caracterizar metalográficamente y evaluar las propiedades mecánicas de los aceros con y sin nitruración AISI 4340 y 34CrNiMo6, para lo cual se obtuvo probetas de dichos materiales mediante el proceso de mecanizado, en lo referente a la evaluación de las propiedades mecánicas se realizó el análisis estadístico respectivo. Se analizó la composición química de ambos aceros mediante el análisis de espectrometría óptica; posteriormente se llevó a cabo el análisis de inclusiones no metálicas, se determinó el tipo, el grado, así como la serie de las inclusiones y se efectuó la comparación de la morfología de estas con la morfología descrita en la norma ASTM E45-11. A continuación se realizó el estudio metalográfico de estos aceros, se observó y comparó las fotomicrografías con ayuda del libro Metals Handbook logrando determinar los microconstituyentes de cada acero. Para determinar las propiedades mecánicas de estos aceros se efectuó los ensayos de dureza Rockwell, impacto y tracción empleando la normativa ASTM (E18-15, E23-18 y A370-21, respectivamente). Para el análisis estadístico se utilizó el diseño experimento 22 logrando como resultado una diferencia significativa de las propiedades mecánicas de los aceros antes de la aplicación del tratamiento de nitruración, el acero AISI 4340 resulta ventajoso en cuanto a tenacidad, esfuerzo de fluencia, así como en esfuerzo último de tracción; en contraste, el acero 34CrNiMo6 presenta ventajas en cuanto a dureza y elongación. Adicionalmente luego de la aplicación de la nitruración no se observó diferencia significativa entre estas propiedades mecánicas. Se concluye que la aplicación del tratamiento de nitruración en estos aceros equipara sus propiedades mecánicas, haciendo posible la intercambiabilidad dentro de procesos productivos. Se recomienda ampliar parámetros de evaluación a fin de aumentar el grado de investigación en este trabajo de titulación.The aim of this study was to characterize metallographically and evaluate the mechanical properties of steels with and without nitriding AISI 4340 and 34CrNiMo6, for which specimens of these materials were obtained through the machining process, in relation to the evaluation of the mechanical properties the respective statistical analysis was performed. On the one hand, the chemical composition of both steels was analyzed by optical spectrometry analysis. On the other hand, the analysis of non-metallic inclusions was carried out, where the type, degree and series of inclusions were determined, as well as the comparison of the morphology with those described in ASTM E45-11. Then, a metallographic study of these steels was then carried out, where the photomicrographs were observed and compared with the help of the Metals Handbook, and the microconstituents of each steel were determined. In order to determine the mechanical properties of these steels, Rockwell hardness, impact and tensile tests were carried out using ASTM standards (E18-15, E23-18 and A370-21, respectively). For the statistical analysis, the design experiment 22 was used, resulting in a significant difference in the mechanical properties of the steels before the application of the nitriding treatment. Thus, AISI 4340 steel is advantageous in regard to toughness, creep stress, as well as ultimate tractive effort. In contrast, 34CrNiMo6 steel has advantages in terms of hardness and elongation. Additionally, no significant difference was observed between these mechanical properties after the application of nitriding. It is concluded that the application of nitriding treatment in these steels associates their mechanical properties, making interchangeability possible within production processes. It is recommended to expand evaluation parameters in order to increase the degree of research in this degree work

Recommendations for the Diagnosis and Treatment of Multiple Sclerosis Relapses

Metilprednisolona; Esclerosi múltiple; RecaigudaMetilprednisolona; Esclerosis múltiple; RecaídaMethylprednisolone; Multiple sclerosis; RelapseMinimizing the risk of relapse is essential in multiple sclerosis (MS). As none of the treatments currently available are capable of completely preventing relapses, treatment of these episodes remains a cornerstone of MS care. The objective of this manuscript is to reduce uncertainty and improve quality of care of this neurological process. This article addresses definitions of key concepts, recommendations for clinical examination, classification criteria, magnetic resonance imaging, biomarkers, and specific therapeutic counsels including special populations such as pregnant and breastfeeding women, and children. An algorithm for treating MS relapses is also provided.This research was funded by NOVARTIS FARMACÉUTICA, SA, for the two expert panel meetings held and the recording and transcription of the content of the first meeting performed by the contract research organization, Dynamic

Corte – Citadelle

Le choix des zones retenues pour les opérations de terrain a été déterminé dans un premier temps par la stricte emprise au sol des bâtiments du futur musée de la Corse. Elles couvraient la totalité du bastion VII, la partie orientale du bastion I et les terrasses jouxtant la caserne Serrurier à l’ouest. Une décision modificative survenue en cours d’intervention a eu pour effet d’élargir les travaux de terrassement à une grande partie du bastion I entraînant de ce fait une extension des fouill..

Early Neolithic Pits at Principal Place, Shoreditch, London Borough of Hackney

A group of four pits excavated in the upper Walbrook valley at Principal Place, Shoreditch by MOLA in 2015 produced the largest assemblage of Early Neolithic Bowl pottery recovered to date from the City of London and its immediate surrounds. The Neolithic pits had been fortuitously preserved within part of the northern extramural Roman cemetery of Londinium and conjoining sherds of Bowl pottery were also recovered from the fill of an isolated late Roman cremation. A range of analyses showed that the vessels – comprising essentially Plain Bowl with some Decorated Bowl, the latter incorporating Peterborough Ware traits – were probably locally made and had been used to process dairy products and to stew beef and mutton (though not pork). Radiocarbon dating of the lipids absorbed within the vessel walls – employing a novel technique developed at the University of Bristol – suggest that the pottery was being used in the mid-fourth millennium cal BC. The pits also contained small assemblages of struck flint, fauna (some burnt) and archaeobotanical remains (some intrusive) and may have been filled using material drawn from a long-vanished ‘pre-pit’ source, possibly a midden; they presumably represent episodic activity on the part of semi-sedentary Neolithic communities

Dating the emergence of dairying by the first farmers of Central Europe using 14C analysis of fatty acids preserved in pottery vessels

Direct, accurate, and precise dating of archaeological pottery vessels is now achievable using a recently developed approach based on the radiocarbon dating of purified molecular components of food residues preserved in the walls of pottery vessels. The method targets fatty acids from animal fat residues, making it uniquely suited for directly dating the inception of new food commodities in prehistoric populations. Here, we report a large-scale application of the method by directly dating the introduction of dairying into Central Europe by the Linearbandkeramik (LBK) cultural group based on dairy fat residues. The radiocarbon dates (n=27) from the 54th century BC from the western and eastern expansion of the LBK suggest dairy exploitation arrived with the first settlers in the respective regions and were not gradually adopted later. This is particularly significant, as contemporaneous LBK sites showed an uneven distribution of dairy exploitation. Significantly, our findings demonstrate the power of directly dating the introduction of new food commodities, hence removing taphonomic uncertainties when assessing this indirectly based on associated cultural materials or other remainsPeer reviewe

TeV Mini Black Hole Decay at Future Colliders

It is generally believed that mini black holes decay by emitting elementary particles with a black body energy spectrum. The original calculation lead to the conclusion that about the 90% of the black hole mass is radiated away in the form of photons, neutrinos and light leptons, mainly electrons and muons. With the advent of String Theory, such a scenario must be updated by including new effects coming from the stringy nature of particles and interactions.By taking for granted that black holes can be produced in hadronic collisions, then their decay must take into account that: (i) we live in a D3-Brane embedded into an higher dimensional bulk spacetime; (ii) fundamental interactions, including gravity, are unified at TeV energy scale. Thus, the formal description of the Hawking radiation mechanism has to be extended to the case of more than four spacetime dimensions and include the presence of D-branes. Furthermore, unification of fundamental interactions at an energy scale many order of magnitude lower than the Planck energy implies that any kind of fundamental particle, not only leptons, is expected to be emitted. A detailed understanding of the new scenario is instrumental for optimal tuning of detectors at future colliders, where, hopefully, this exciting new physics will be tested. In this article we review higher dimensional black hole decay, considering not only the emission of particles according to Hawking mechanism, but also their near horizon QED/QCD interactions. The ultimate motivation is to build up a phenomenologically reliable scenario, allowing a clear experimental signature of the event.Comment: 22 pages, 9 figures, 4 tables; ``quick review'' for Class. and Quantum Gra

Accurate compound-specific 14C dating of archaeological pottery vessels

Pottery is one of the most commonly recovered artefacts from archaeological sites. Despite more than a century of relative dating based on typology and seriation, accurate dating of pottery by the radiocarbon method has proven extremely challenging due to the limited survival of organic temper and unreliability of visible residues. We report here a new method of dating directly archaeological pottery based on accelerator mass spectrometry (AMS) analysis of 14C in absorbed food residues: palmitic (C16:0) and stearic (C18:0) fatty acids purified by preparative gas chromatography (pcGC). We present the first accurate compound-specific radiocarbon determinations of lipids extracted from pottery vessels, which were rigorously evaluated by comparison with dendrochronological dates and inclusion in site and regional chronologies containing suites of radiocarbon dates on other materials . Critically, the compound-specific dates from each of the C16:0 and C18:0 fatty acids in pottery vessels provide an internal quality control of the results and, are entirely compatible with dates for other commonly dated materials. Accurate radiocarbon dating of pottery vessels can reveal: (i) the period of use of pottery; (ii) the antiquity of organic residues including when specific foodstuffs were exploited; (iii) sites chronologies in the absence of traditionally datable materials and (iv) direct verification of pottery typochronologies. As exemplars, the method was applied to the dating of dairy and carcass product exploitation in Neolithic vessels, from Britain, Anatolia, central and western Europe, and Saharan Africa.Additional co-authors: Christian Jeunesse, Marta Krueger, Arkadiusz Marciniak, Steve Minnitt, Rocco Rotunno, Pieter van de Velde, Ivo van Wijk, Jonathan Cotton, Andy Daykin, Richard P Evershe