Hatching phenology and voltinism of Heterocypris barbara (Crustacea: Ostracoda) from Lampedusa (Sicily, Italy)

The persistence of crustacean populations in ephemeral ponds requires appropriate adaptations in life history strategies (e.g. in hatching phenology). Organisms take advantage of pond filling when it occurs and hedge their bets for the possibility to complete one or more life cycles or to produce resting stages that ensure that the population will not go extinct. We carried out laboratory experiments to investigate the dynamics of a sexual population of Heterocypris barbara from a vernal pool in Lampedusa Island (Sicily). Experimental organisms were obtained hydrating sediments from Aria Rossa temporary pond. Recruitment from resting eggs, voltinism, mean body size and sex ratio were observed in microcosms at different conductivities (high 2.0-2.7 mS cm-1, intermediate 1.0-1.1 mS cm-1 and low 0.5-0.6 mS cm-1). Microcosms were kept in laboratory controlled conditions: constant (24°C 12:12 L:D and 16°C 10:14 L:D photoperiod) or fluctuating thermal regimes. The experiment lasted 7 months. Resting and non-resting egg production and up to a bivoltine life cycle were observed. Recruitment events from egg bank and voltinism varied by thermal regime and conductivity. A prolonged recruitment phase occurred in conditions that could be considered a proxy of a rainy season (16°C, 10:14 L:D and low conductivity) or of long hydroperiods (spring thermal fluctuating regime and intermediate conductivity). At 24°C, age at reproduction of females from resting eggs almost doubled at low conductivity (in comparison with high conductivity). Low conductivity also reduced hatching time of resting eggs while it increased development time and age at maturity. In thermal fluctuating regime, degree-days to reproduction were about double than at constant 24°C. Males, observed in all microcosms, reached maturity faster and had a shorter life span than females. Males initially outnumbered females, but later in the experiments females became dominant. We also evaluated the effect of conductivity and thermal regimes on other traits like recruitment from egg bank, voltinism and sex ratio. We discuss whether our observations on a small population from temporary pools could be considered part of a diversified bet-hedging strategy

Virtual multichannel SAR for ground moving target imaging

Slow moving ground targets are invisible within synthetic aperture radar (SAR) images since they appear defocused and their backscattered signal completely overlap the focused ground return. In order for this targets to be detected and refocused the availability of some spatial degrees of freedom is required. This allows for space/slow time processing to be applied to mitigate the ground clutter. However, multichannel SAR (M-SAR) systems are very expensive and the requirements in terms of baseline length can be very restrictive. In this study a processing scheme that exploits high PRF single channel SAR system to emulate a multichannel SAR is presented. The signal model for both target and clutter components are presented and the difference with respect to an actual M-SAR are highlighted. The effectiveness of the proposed processing is then demonstrated on simulated a measured dataset

Effect of prolonged treatment with phosphodiesterase-5-inhibitors on endothelial dysfunction in vascular diseases and vascular risk conditions: A systematic review analysis and meta-analysis of randomized double-blind placebo-controlled trials.

OBJECTIVE To challenge the argument that continuous use of phosphodiesterase-5-selective inhibitors may reduce endothelial cell dysfunction in patients with vascular diseases or vascular risk conditions. DESIGN This study included systematic reviews and meta-analysis of randomized double-blind placebo-controlled trials dealing with the prolonged use of phosphodiesterase-5-selective inhibitors. The risk of bias and quality of trials were assessed by the Cochrane algorithm. Fixed or random effect models, standardised mean differences and heterogeneity were estimated in the study. DATA SOURCES Systematic search for randomized double-blind placebo-controlled trials was done in PubMed, Scopus, CINAHL, Science direct and the Cochrane Library. ELIGIBILITY CRITERIA FOR SELECTING STUDIES Randomized double-blind placebo-controlled trials reporting measures of endothelial cell dysfunction and/or endothelial cell activation were included. RESULTS On the whole, 469 subjects were allocated to the phosphodiesterase-5-selective inhibitor group, while 463 were assigned to the placebo group in 13 randomized double-blind placebo-controlled trials. Flow-mediated dilation of the brachial artery was found to improve after the administration of phosphodiesterase-5-selective inhibitors (P < 0.0001). The results were questioned by the elevated and uncorrectable heterogeneity (I2 = 92%) and the asymmetry of the funnel plot suggested a publication bias. Phosphodiesterase-5-selective inhibitors have no effect on endothelial cell dysfunction, as assessed in the resistance vessels by digital arterial tonometry. The blood level of endothelin-1 was observed to be decreased in phosphodiesterase-5-selective inhibitors arm (P = 0.03), although the effect disappeared once the publication bias and heterogeneity were corrected. The effect of phosphodiesterase-5-selective inhibitors on biomarkers of endothelial cell activation was found to be inconsistent. CONCLUSIONS The results on the benefits of a prolonged use of phosphodiesterase-5-selective inhibitors, with the objective of lowering endothelial cell dysfunction in patients with vascular diseases or vascular risk conditions are not convincing. This is because of the overall low quality of evidence, giving an unclear scientific support to this treatment. Systematic review registration: PROSPERO registration: CRD42017055399

Compressive sensing for interferometric inverse synthetic aperture radar applications

The applicability of interferometric inverse synthetic aperture radar (InISAR) techniques to images reconstructed via compressive sensing (CS)-based algorithms is investigated. Specifically, the three-dimensional (3D) reconstruction algorithm is applied after exploiting CS for data compression and image reconstruction. The InISAR signal model is derived and formalised in a CS framework. A comparison between conventional CS reconstruction and global sparsity constrained reconstruction techniques is performed for different compression rates and different signal-to-noise ratio conditions. Performances on the 2D and 3D reconstructions are evaluated. Results obtained on real data acquired during the NATO-SET 196 trial are shown

Testicular Cancer in Infertile Men With and Without Testicular Microlithiasis: A Systematic Review and Meta-Analysis of Case-Control Studies

Background: An association between testicular microlithiasis (TM) and both carcinoma in situ (CIS) of the testis and testicular germ cell tumors (TGCTs) has been reported. Furthermore, TM seems to be significantly more prevalent in men with male-factor infertility, representing itself a risk factor for TGCT. Nevertheless, the evidence of the association of TM with a higher prevalence of testicular cancer in infertile men remains inconclusive. The aim of this study was to systematically evaluate whether, and to what extent, TM is associated to a significantly higher prevalence of testicular cancer in infertile males.Methods: A thorough search of MEDLINE, SCOPUS, CINAHL, WEB OF SCIENCE, and Cochrane Library databases was carried out to identify case-control studies comparing the prevalence of testicular cancer in infertile men with and without TM. Methodological quality of the studies was assessed using the Newcastle-Ottawa Scale. In the absence of heterogeneity, odds ratios (ORs) with 95% confidence intervals (CIs) for testicular cancer were combined using a fixed effect model. Funnel plots and trim-and-fill analysis were used to assess publication bias.Results: Eight studies met the inclusion criteria and provided information on 180 infertile men with TM and 5,088 infertile men without TM. The pooled OR indicated that the presence of TM is associated with a ~18-fold higher odd for testicular cancer (pooled OR:18.11, 95%CI: 8.09, 40.55; P &lt; 0.0001). No heterogeneity among the studies was observed (Pfor heterogeneity = 0.99, I2 = 0%). At the sensitivity analysis, similar pooled ORs and 95%CIs were generated with the exclusion of each study, indicating the high degree of stability of the results. The funnel plot revealed a possible publication bias and the trim-and-fill test detected two putative missing studies. Nevertheless, even when the pooled estimate was adjusted for publication bias, there was a still significantly higher odd for testicular cancer in the TM group (adjusted pooled OR: 16.42, 95%CI: 7.62, 35.37; P &lt; 0.0001).Conclusions: In infertile men the presence of TM is associated to an ~18-fold higher prevalence of testicular cancer. Longitudinal studies are warranted to elucidate whether this cross-sectional association actually reflects a higher susceptibility of infertile men with TM to develop testicular cancer over time

Hatching phenology and voltinism of Heterocypris barbara (Crustacea: Ostracoda) from Lampedusa (Sicily, Italy)

The persistence of crustacean populations in ephemeral ponds requires appropriate adaptations in life history strategies (e.g. in hatching phenology). Organisms take advantage of pond filling when it occurs and hedge their bets for the possibility to complete one or more life cycles or to produce resting stages that ensure that the population will not go extinct. We carried out laboratory experiments to investigate the dynamics of a sexual population of Heterocypris barbara from a vernal pool in Lampedusa Island (Sicily). Experimental organisms were obtained hydrating sediments from Aria Rossa temporary pond. Recruitment from resting eggs, voltinism, mean body size and sex ratio were observed in microcosms at different conductivities (high 2.0-2.7 mS cm-1, intermediate 1.0-1.1 mS cm-1 and low 0.5-0.6 mS cm-1). Microcosms were kept in laboratory controlled conditions: constant (24°C 12:12 L:D and 16°C 10:14 L:D photoperiod) or fluctuating thermal regimes. The experiment lasted 7 months. Resting and non-resting egg production and up to a bivoltine life cycle were observed. Recruitment events from egg bank and voltinism varied by thermal regime and conductivity. A prolonged recruitment phase occurred in conditions that could be considered a proxy of a rainy season (16°C, 10:14 L:D and low conductivity) or of long hydroperiods (spring thermal fluctuating regime and intermediate conductivity). At 24°C, age at reproduction of females from resting eggs almost doubled at low conductivity (in comparison with high conductivity). Low conductivity also reduced hatching time of resting eggs while it increased development time and age at maturity. In thermal fluctuating regime, degree-days to reproduction were about double than at constant 24°C. Males, observed in all microcosms, reached maturity faster and had a shorter life span than females. Males initially outnumbered females, but later in the experiments females became dominant. We also evaluated the effect of conductivity and thermal regimes on other traits like recruitment from egg bank, voltinism and sex ratio. We discuss whether our observations on a small population from temporary pools could be considered part of a diversified bet-hedging strategy

High resolution imaging of moving ground targets via clutter mitigation and ISAR processing

Non-cooperative moving targets appear defocussed within SAR images. Moreover, in the case of ground targets, the blurring effect due to the uncompensated target motion decreases detection capabilities. In this work, clutter suppression by means of Space Doppler Adaptive Processing and ISAR imaging are combined to obtain high resolution images of non-cooperative moving targets within SAR images. Results obtained by processing a real dataset prove the effectiveness of the proposed processing chain