ASTRI SST-2M archive system: a prototype for the Cherenkov Telescope Array

The ASTRI project of the Italian National Institute for Astrophysics (INAF) is developing, in the framework of the Cherenkov Telescope Array (CTA), an end-to-end prototype system based on a dual-mirror small-sized Cherenkov telescope. Data preservation and accessibility are guaranteed by means of the ASTRI Archive System (AAS) that is responsible for both the on-site and off-site archiving of all data produced by the different sub- systems of the so-called ASTRI SST-2M prototype. Science, calibration, and Monte Carlo data together with the dedicated Instrument Response Functions (IRFs) (and corresponding metadata) will be properly stored and organized in different branches of the archive. A dedicated technical data archive (TECH archive) will store the engineering and auxiliary data and will be organized under a parallel database system. Through the use of a physical system archive and a few logical user archives that reflect the different archive use-cases, the AAS has been designed to be independent from any specific data model and storage technology. A dedicated framework to access, browse and download the telescope data has been identified within the proposal handling utility that stores and arranges the information of the observational proposals. The development of the whole archive system follows the requirements of the CTA data archive and is currently carried out by the INAF-OAR & ASI-Science Data Center (ASDC) team. The AAS is fully adaptable and ready for the ASTRI mini-array that, formed of at least nine ASTRI SST-2M telescopes, is proposed to be installed at the CTA southern site

Serum BPIFB4 levels classify health status in long-living individuals

People that reach extreme ages (Long-Living Individuals, LLIs) are object of intense investigation for increase/decrease of genetic variant frequencies, genetic methylation levels, protein abundance in serum and tissues. The aim of these studies is the discovery of the mechanisms behind LLIs extreme longevity and the identification of markers of well-being. We have recently associated a BPIFB4 haplotype (LAV) with exceptional longevity under a homozygous genetic model, and identified that CD34(+) of LLIs subjects express higher BPIFB4 transcript as compared to CD34(+) of control population. It would be of interest to correlate serum BPIFB4 protein levels with exceptional longevity and health status of LLIs

Failure modes and reliability oriented system design for aerospace power electronic converters

Aircraft electrification has been a major trend in aviation industry for past 20 years. Given the increasing electrical power requirement for future more electric aircraft and hybrid electric aircraft, research efforts has been ongoing in high power electrical conversion for air-borne systems. Safety critical nature of aviation systems places reliability of aerospace power converters as a critical design concern. In this paper, power electronic system reliability is studied with emphasis on lifetime limiting factors of critical sub components. Reliability of voltage source power converters at different system voltage levels are modelled for a starter generator drive converter. A key observation is that Si IGBT devices are sufficient with respect to reliability requirements in low and medium voltage systems (up to 540 V). At higher system voltages (above 540 V), multi level topologies are necessary for designing with Si IGBTs. In constant power profile drive, system reliability is minimally affected by wear-out failure of film capacitors in converter DC links. In multi level topologies without enhanced voltage derating, system reliability is dominated by cosmic ray induced random failures. Simulation results demonstrate that at high system voltages (810 V), 2 L topology with SiC mosfets outperform Si IGBT based 3 L topology with respect to reliability

Vertically resolved precipitation intensity retrieved through a synergy between the ground-based NASA MPLNET lidar network measurements, surface disdrometer datasets and an analytical model solution

In this paper, we illustrate a new, simple and complementary ground-based methodology to retrieve the vertically resolved atmospheric precipitation intensity through a synergy between measurements from the National Aeronautics and Space Administration (NASA) Micropulse Lidar network (MPLNET), an analytical model solution and ground-based disdrometer measurements. The presented results are obtained at two mid-latitude MPLNET permanent observational sites, located respectively at NASA Goddard Space Flight Center, USA, and at the Universitat Politècnica de Catalunya, Barcelona, Spain. The methodology is suitable to be applied to existing and/or future lidar/ceilometer networks with the main objective of either providing near real-time (3 h latency) rainfall intensity measurements and/or to validate satellite missions, especially for critical light precipitation (< 3 mm h-1).Peer ReviewedPostprint (published version

Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms

The contribution of nutrient availability to control epidermal cell proliferation, inflammation, and hyperproliferative diseases remains unknown. Here, we studied extracellular serine and serine/glycine metabolism using human keratinocytes, human skin biopsies, and a mouse model of psoriasis-like disease. We focused on a metabolic enzyme, serine hydroxymethyltransferase (SHMT), that converts serine into glycine and tetrahydrofolate-bound one‑carbon units to support cell growth. We found that keratinocytes are both serine and glycine auxotrophs. Metabolomic profiling and hypoxanthine supplementation indicated that SHMT silencing/inhibition reduced cell growth through purine depletion, leading to nucleotide loss. In addition, topical application of an SHMT inhibitor suppressed both keratinocyte proliferation and inflammation in the imiquimod model and resulted in a decrease in psoriasis-associated gene expression. In conclusion, our study highlights SHMT2 activity and serine/glycine availability as an important metabolic hub controlling both keratinocyte proliferation and inflammatory cell expansion in psoriasis and holds promise for additional approaches to treat skin diseases

Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis

Long living individuals show delay of aging, which is characterized by the progressive loss of cardiovascular homeostasis, along with reduced endothelial nitric oxide synthase activity, endothelial dysfunction, and impairment of tissue repair after ischemic injury

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

EVALITA Evaluation of NLP and Speech Tools for Italian - December 17th, 2020

Welcome to EVALITA 2020! EVALITA is the evaluation campaign of Natural Language Processing and Speech Tools for Italian. EVALITA is an initiative of the Italian Association for Computational Linguistics (AILC, http://www.ai-lc.it) and it is endorsed by the Italian Association for Artificial Intelligence (AIxIA, http://www.aixia.it) and the Italian Association for Speech Sciences (AISV, http://www.aisv.it)

A first update on mapping the human genetic architecture of COVID-19

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