Michelson-Morley Experiments: at the crossroads of Relativity, Cosmology and Quantum Physics

Quantum nonlocality would naturally fit into a version of relativity with a preferred reference system. However, acceptance of this idea has traditionally required experimental evidence. Namely, detecting in laboratory a small angular dependence of the velocity of light correlated to the cosmic motion of the Earth. Here, we summarize a new theoretical framework where the tiny, irregular residuals observed so far, from Michelson-Morley to current experiments of laser interferometry, can indeed be understood in terms of the Earth motion in the Cosmic Microwave Background observed directly with satellites in space. Our results, challenging the usual null interpretation, emphasize the central role of 'ether-drift' experiments for Relativity, Cosmology and Quantum Physics.Comment: 60 pages, 25 figures and 3 table

Artificial Neural Networks for Predicting the Water Retention Curve of Sicilian Agricultural Soils

Modeling soil-water regime and solute transport in the vadose zone is strategic for estimating agricultural productivity and optimizing irrigation water management. Direct measurements of soil hydraulic properties, i.e., the water retention curve and the hydraulic conductivity function, are often expensive and time-consuming, and represent a major obstacle to the application of simulation models. As a result, there is a great interest in developing pedotransfer functions (PTFs) that predict the soil hydraulic properties from more easily measured and/or routinely surveyed soil data, such as particle size distribution, bulk density (ρb), and soil organic carbon content (OC). In this study, application of PTFs was carried out for 359 Sicilian soils by implementing five different artificial neural networks (ANNs) to estimate the parameter of the van Genuchten (vG) model for water retention curves. The raw data used to train the ANNs were soil texture, ρb, OC, and porosity. The ANNs were evaluated in their ability to predict both the vG parameters, on the basis of the normalized root-mean-square errors (NRMSE) and normalized mean absolute errors (NMAE), and the water retention data. The Akaike's information criterion (AIC) test was also used to assess the most efficient network. Results confirmed the high predictive performance of ANNs with four input parameters (clay, sand, and silt fractions, and OC) in simulating soil water retention data, with a prediction accuracy characterized by MAE = 0.026 and RMSE = 0.069. The AIC efficiency criterion indicated that the most efficient ANN model was trained with a relatively low number of input nodes

Two-loop heavy top effects on the MZ-MW interdependence

The O(alpha^2 mt^2/mw^2) correction to the relation between G_\mu and the vector boson masses is computed in the MSbar scheme, and the results are used to investigate the magnitude of the effect on the theoretical prediction of mw and sin^2\theta_\msbar(mz) from alpha, G_\mu, and mz.Comment: 11 pages, LaTeX, includes 1 LaTeX figure, uses equations.sty and cite.sty, one minor comment and interpolation function for variable mtop added, no change in the result

Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage

Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before HD onset. A human iPS cell line was generated from skin fibroblasts of a subject at the presymptomatic life stage, carrying a polyglutamine expansion in HTT gene codifying Huntingtin protein. The iPSC line contained the expected CAG expansion, expressed the expected pluripotency markers, displayed in vivo differentiation potential to the three germ layers and had a normal karyotype

Alpha-synuclein gene duplication: Marked intrafamilial variability in two novel pedigrees

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Biallelic mutations in DYNC2LI1 are a rare cause of Ellis-van Creveld syndrome

Ellis van Creveld syndrome (EvC) is a chondral and ectodermal dysplasia caused by biallelic mutations in the EVC, EVC2 and WDR35 genes. A proportion of cases with clinical diagnosis of EvC, however, do not carry mutations in these genes. To identify the genetic cause of EvC in a cohort of mutation-negative patients, exome sequencing was undertaken in a family with three affected members, and mutation scanning of a panel of clinically and functionally relevant genes was performed in 24 additional subjects with features fitting/overlapping EvC. Compound heterozygosity for the c.2T>C (p.Met1?) and c.662C>T (p.Thr221Ile) variants in DYNC2LI1, which encodes a component of the intraflagellar transport-related dynein-2 complex previously found mutated in other short-rib thoracic dysplasias, was identified in the three affected members of the first family. Targeted resequencing detected compound heterozygosity for the same missense variant and a frameshift change (p.Val141*) in two siblings with EvC from a second family, while a newborn with a more severe phenotype carried two DYNC2LI1 truncating variants. Our findings indicate that DYNC2LI1 mutations are associated with a wider clinical spectrum than previously appreciated, including EvC, with the severity of the phenotype likely depending on the extent of defective DYNC2LI1 function

Generation of induced pluripotent stem cell line, CSSi002-A (2851), from a patient with juvenile Huntington Disease

Abstract Huntington Disease (HD) is an autosomal dominant disorder characterized by motor, cognitive and behavioral features caused by a CAG expansion in the HTT gene beyond 35 repeats. The juvenile form (JHD) may begin before the age of 20 years and is associated with expanded alleles as long as 60 or more CAG repeats. In this study, induced pluripotent stem cells were generated from skin fibroblasts of a 8-year-old child carrying a large size mutation of 84 CAG repeats in the HTT gene. HD appeared at age 3 with mixed psychiatric (i.e. autistic spectrum disorder) and motor (i.e. dystonia) manifestations

Kinematics and strain analyses of the eastern segment of the Pernicana Fault (Mt. Etna, Italy) derived from geodetic techniques (1997-2005)

This paper analyses the ground deformations occurring on the eastern part of the Pernicana Fault from 1997 to 2005. This segment of the fault was monitored with three local networks based on GPS and EDM techniques. More than seventy GPS and EDM surveys were carried out during the considered period, in order to achieve a higher temporal detail of ground deformation affecting the structure. We report the comparisons among GPS and EDM surveys in terms of absolute horizontal displacements of each GPS benchmark and in terms of strain parameters for each GPS and EDM network. Ground deformation measurements detected a continuous left-lateral movement of the Pernicana Fault. We conclude that, on the easternmost part of the Pernicana Fault, where it branches out into two segments, the deformation is transferred entirely SE-wards by a splay fault

Generation of the induced pluripotent stem cell line CSSi006-A (3681) from a patient affected by advanced-stage Juvenile Onset Huntington's Disease

Abstract Juvenile Onset Huntington's Disease (JOHD) is a rare variant of HD withage of onset ≤20 years, accounting for 3–10% of all HD patients. The rarity occurrence of JOHD cases, who severely progress towards mental and physical disability with atypical clinical manifestations compared to classical HD, are responsible of general lack of knowledge about this variant. We obtained a fully reprogrammed iPS cell line from fibroblasts of a JOHD patient carrying 65 CAG repeats and age at onset at age 15. At the biopsy time, the patient showed an advanced stage after 10 years of disease