Fibrosis: a role for vitamin D

Chronic inflammation leads to fibrosis and eventually organ failure. Fibrosis is defined as a wound-healing response that has gone awry. It is featured by excessive production, deposition, and accumulation of extracellular matrix components. The key mediator cells of fibrotic disorders are the myofibroblasts, derived from different precursor cells. Myofibroblasts are responsible of stiff ECM, a hallmark of fibrosis. It is mandatory understanding the molecular pathways contributing to develop the fibrotic tissue to discovery anti-fibrotic therapies. Vitamin D, the precursor of seco-steroid hormone, appears to have anti-fibrotic properties. Vitamin D deficiency may contribute to development of different fibrotic disorders in several organs. It counteracts the pro-fibrotic signals, such as TGF-β1, through several biochemical mechanisms. Counteracting TGF-β1, Vitamin D inhibits myofibroblasts activation and ECM deposition

Self-Injurious Thoughts and Behaviors Questionnaire-Nonsuicidal (SITBQ-NS): Development and validation of a revised version of the Self-Injurious Thoughts and Behaviors Interview (SITBI) for the self-assessment of nonsuicidal self-injury

Objective: Despite the fact that nonsuicidal self-injury (NSSI) has become an important issue among clinicians and researchers all over the world, in Italy there is still a lack of instruments able to assess it. The objective of this study is to develop and validate the Self-Injurious Thoughts and Behaviors Questionnaire-Nonsuicidal (SITBQ-NS), a self-report measuring the whole NSSI spectrum, that is, from ideation to act. Method: SITBQ-NS was administered to 51 adult patients recruited from public mental health services together with the Millon Clinical Multiaxial Inventory (MCMI-III), the Beck Hopelessness Scale (BHS), the Deliberate Self-Harm Inventory (DSHI), and the Nepean Dysphoria Scale (NDS-I). Results: SITBQ-NS demonstrated excellent internal consistency (α=0.983). NSSI thoughts were present in 56.9% of participants, and NSSI behaviors were present in 49% of participants. Similar NSSI functions were found among participants, except for “To end suicidal ideation,” which was more common among those having NSSI thoughts (34.1%) than those exhibiting NSSI behaviors (21.6%). There were strong positive correlations between the scores of SITBQ-NS and the scores of BHS, DSHI and NDS-I. Also, there were weak to strong positive correlations between the scores of SITBQ-NS and some MCMI-III scales. Conclusions: The SITBQ-NS shows very good psychometric properties, being a useful and easy-to-handle instrument for measuring the whole NSSI spectrum. Further research in clinical samples is neede

a novel mutation with mild clinical presentation

Background A highly variable phenotype characterized by thyroid, respiratory and neurological defects has been reported in an already established group of disorders namely NKX2.1-related disorders. We describe here the case of an infant with a novel mutation of the NKX2.1 gene characterized by mild clinical presentation. Aim of the study was to elucidate the genotype-phenotype correlation in our patient. Methods We performed genetic analysis of the NKX2.1 gene in an infant with no neonatal respiratory distress and near-normal results at neonatal screening test for congenital hypothyroidism, choreoathetosis, ataxia and delayed independent walking. Results A novel mutation of the NKX2.1 gene has been identified, that is responsible for a mild framework of congenital hypothyroidism and neurological symptoms. Conclusions The frequency of congenital hypothyroidism cases associated with NKX2.1 mutations is expected to be higher in a subgroup of patients, selected according to the neurological presentation. In these patients the analysis of NKX2.1 mutational status is recommended

NKX2.1-Related Disorders: a novel mutation with mild clinical presentation.

Background: A highly variable phenotype characterized by thyroid, respiratory and neurological defects has been reported in an already established group of disorders namely NKX2.1-related disorders. We describe here the case of an infant with a novel mutation of the NKX2.1 gene characterized by mild clinical presentation. Aim of the study was to elucidate the genotype-phenotype correlation in our patient. Methods: We performed genetic analysis of the NKX2.1 gene in an infant with no neonatal respiratory distress and near-normal results at neonatal screening test for congenital hypothyroidism, choreoathetosis, ataxia and delayed independent walking. Results: A novel mutation of the NKX2.1 gene has been identified, that is responsible for a mild framework of congenital hypothyroidism and neurological symptoms. Conclusions: The frequency of congenital hypothyroidism cases associated with NKX2.1 mutations is expected to be higher in a subgroup of patients, selected according to the neurological presentation. In these patients the analysis of NKX2.1 mutational status is recommended

Unenhanced whole-body MRI versus PET-CT for the detection of prostate cancer metastases after primary treatment

The aim of this study was to evaluate the accuracy of unenhanced whole-body MRI, including whole-body Diffusion Weighted Imaging (DWI), used as a diagnostic modality to detect  pathologic lymph nodes and skeletal metastases in patients with prostate cancer (PCa) undergoing restaging after primary treatment

Synthetic peptides blocking sars-cov-2 (covid-19), and compositions, methods and uses related thereto

The invention relates to the field of medicine and therapeutically active peptides, more specifically to the design of peptides that antagonise Angiotensin-Converting Enzyme-2 (ACE-2) interaction with the receptor binding spike protein of SARS-CoV-2. Provided is a peptidic compound comprising or consisting of an amino acid sequence selected from the following: IYALLENAEDYNLVN, SRDKHEEHEKENDRGQ, DKFNHEAEDLFYQSSLASWNYNT, IEEQAKTFLDKFQHEVEEIYWQS, QDKHEEDYQMYNKGDKED and IDENARSYIDKFQHDAEEMWYQ, or an amide, an ester or a salt thereof

Lockdown: How the COVID-19 Pandemic Affected the Fishing Activities in the Adriatic Sea (Central Mediterranean Sea)

The coronavirus disease 2019 (COVID-19) has brought a global socio-economic crisis to almost all sectors including the fishery. To limit the infection, governments adopted several containment measures. In Italy, Croatia, and Slovenia, a lockdown period was imposed from March to May 2020, during which many activities, including restaurants had to close or limit their business. All of this caused a strong reduction in seafood requests and consequently, a decrease in fishing activities. The aim of this study is to investigate the effects of the COVID-19 in the Northern and Central Adriatic fleet, by comparing the fishing activities in three periods (before, during, and after the lockdown) of 2019 and 2020. The use of the Automatic Identification System(AIS) data allowed us to highlight the redistribution of the fishing grounds of the trawlers, mainly located near the coasts during the 2020 lockdown period, as well as a reduction of about 50% of fishing effort. This reduction resulted higher for the Chioggia trawlers (−80%) and, in terms of fishing effort decrease, the large bottom otter trawl was the fishing segment mainly affected by the COVID-19 event. Moreover, by analysing the landings of the Chioggia fleet and the Venice lagoon fleets, it was possible to point out a strong reduction both in landings and profits ranging from −30%, for the small-scale fishery operating at sea, to −85%, for the small bottom otter trawl