3,566 research outputs found
Double-carbapenem regimen, alone or in combination with colistin, in the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp)
Ion dynamics and coherent structure formation following laser pulse self-channeling
The propagation of a superintense laser pulse in an underdense, inhomogeneous
plasma has been studied numerically by two-dimensional particle-in-cell
simulations on a time scale extending up to several picoseconds. The effects of
the ion dynamics following the charge-displacement self-channeling of the laser
pulse have been addressed. Radial ion acceleration leads to the ``breaking'' of
the plasma channel walls, causing an inversion of the radial space-charge field
and the filamentation of the laser pulse. At later times a number of
long-lived, quasi-periodic field structures are observed and their dynamics is
characterized with high resolution. Inside the plasma channel, a pattern of
electric and magnetic fields resembling both soliton- and vortex-like
structures is observed.Comment: 10 pages, 5 figures (visit http://www.df.unipi.it/~macchi to download
a high-resolution version), to appear in Plasma Physics and Controlled Fusion
(Dec. 2007), special issue containing invited papers from the 34th EPS
Conference on Plasma Physics (Warsaw, July 2007
Electron-Phonon Coupling in Highly-Screened Graphene
Photoemission studies of graphene have resulted in a long-standing
controversy concerning the strength of the experimental electron-phonon
interaction in comparison with theoretical calculations. Using high-resolution
angle-resolved photoemission spectroscopy we study graphene grown on a copper
substrate, where the metallic screening of the substrate substantially reduces
the electron-electron interaction, simplifying the comparison of the
electron-phonon interaction between theory and experiment. By taking the
nonlinear bare bandstructure into account, we are able to show that the
strength of the electron-phonon interaction does indeed agree with theoretical
calculations. In addition, we observe a significant bandgap at the Dirac point
of graphene.Comment: Submitted to Phys. Rev. Lett. on July 20, 201
Tension cost correlates with mechanical and biochemical parameters in different myocardial contractility conditions
OBJECTIVES: Tension cost, the ratio of myosin ATPase activity to tension, reflects the economy of tension development in the myocardium. To evaluate the mechanical advantage represented by the tension cost, we studied papillary muscle contractility and the activity of myosin ATPase in the left ventricles in normal and pathophysiological conditions. METHODS: Experimental protocols were performed using rat left ventricles from: (1) streptozotocin-induced diabetic and control Wistar rats; (2) N-nitro-L-arginine methyl ester (L-NAME) hypertensive and untreated Wistar rats; (3) deoxycorticosterone acetate (DOCA) salt-treated, nephrectomized and salt- and DOCA-treated rats; (4) spontaneous hypertensive rats (SHR) and Wistar Kyoto (WKY) rats; (5) rats with myocardial infarction and shamoperated rats. The isometric force, tetanic tension, and the activity of myosin ATPase were measured. RESULTS: The results obtained from infarcted, diabetic, and deoxycorticosterone acetate-salt-treated rats showed reductions in twitch and tetanic tension compared to the control and sham-operated groups. Twitch and tetanic tension increased in the N-nitro-L-arginine methyl ester-treated rats compared with the Wistar rats. Myosin ATPase activity was depressed in the infarcted, diabetic, and deoxycorticosterone acetate salt-treated rats compared with control and sham-operated rats and was increased in N-nitro-L-arginine methyl ester-treated rats. These parameters did not differ between SHR and WKY rats. In the studied conditions (e.g., post-myocardial infarction, deoxycorticosterone acetate salt-induced hypertension, chronic N-nitro-L-arginine methyl ester treatment, and streptozotocin-induced diabetes), a positive correlation between force or plateau tetanic tension and myosin ATPase activity was observed. CONCLUSION: Our results suggest that the myocardium adapts to force generation by increasing or reducing the tension cost to maintain myocardial contractility with a better mechanical advantage
Collecting Dust in the Upper Stratosphere at high latitudes: Constraints on the Compositions of Cosmic Dust Particles
Low Thrust Propelled Close Approach Maneuvers
The study of orbital maneuvers in space missions is a very important problem in astrodynamics. One of the options is the use of a “gravity assisted” maneuver, which is a technique where a spacecraft passes close to a celestial body and uses the gravity of this body to change its trajectory. This approach trajectory has symmetry with respect to the periapsis line when observed from a reference frame fixed in the approached body. There is also a more complex maneuver, when the passage by the celestial body is combined with the application of propulsion, either to give extra energy to the spacecraft or to help to satisfy other constraints required by the mission, like passing by a giving point or region in space. The main object of this study is to measure the efficiency of the application of a continuous thrust combined with the “gravity assisted” maneuver. The effect of this combination is analyzed using maps that give the energy variation of the spacecraft as function of the parameters related to the maneuver. This analysis is made from the point of view of the variation of energy of the spacecraft with respect to the main body of the system. The continuous thrust is applied in the different regions of the trajectory to evaluate the effects of the locations of the thrusting arcs in the variations of energy. The effects of the variations of the direction of the thrust are also studied. This type of combined maneuver may be used to give extra energy to the spacecraft and keeping control of the trajectory during the close approach to better position the spacecraft to complete the mission
Reconstruction and thermal stability of the cubic SiC(001) surfaces
The (001) surfaces of cubic SiC were investigated with ab-initio molecular
dynamics simulations. We show that C-terminated surfaces can have different
c(2x2) and p(2x1) reconstructions, depending on preparation conditions and
thermal treatment, and we suggest experimental probes to identify the various
reconstructed geometries. Furthermore we show that Si-terminated surfaces
exhibit a p(2x1) reconstruction at T=0, whereas above room temperature they
oscillate between a dimer row and an ideal geometry below 500 K, and sample
several patterns including a c(4x2) above 500 K.Comment: 12 pages, RevTeX, figures 1 and 2 available in gif form at
http://irrmawww.epfl.ch/fg/sic/fig1.gif and
http://irrmawww.epfl.ch/fg/sic/fig2.gi
Relating gravitational wave constraints from primordial nucleosynthesis, pulsar timing, laser interferometers, and the CMB: implications for the early universe
We derive a general master equation relating the gravitational-wave
observables r and Omega_gw(f). Here r is the tensor-to-scalar ratio,
constrained by cosmic-microwave-background (CMB) experiments; and Omega_gw(f)
is the energy spectrum of primordial gravitational-waves, constrained e.g. by
pulsar-timing measurements, laser-interferometer experiments, and Big Bang
Nucleosynthesis (BBN). Differentiating the master equation yields a new
expression for the tilt d(ln Omega_gw(f))/d(ln f). The relationship between r
and Omega_gw(f) depends sensitively on the uncertain physics of the early
universe, and we show that this uncertainty may be encapsulated (in a
model-independent way) by two quantities: w_hat(f) and nt_hat(f), where
nt_hat(f) is a certain logarithmic average over nt(k) (the primordial tensor
spectral index); and w_hat(f) is a certain logarithmic average over w_tilde(a)
(the effective equation-of-state in the early universe, after horizon
re-entry). Here the effective equation-of-state parameter w_tilde(a) is a
combination of the ordinary equation-of-state parameter w(a) and the bulk
viscosity zeta(a). Thus, by comparing constraints on r and Omega_gw(f), one can
obtain (remarkably tight) constraints in the [w_hat(f), nt_hat(f)] plane. In
particular, this is the best way to constrain (or detect) the presence of a
``stiff'' energy component (with w > 1/3) in the early universe, prior to BBN.
Finally, although most of our analysis does not assume inflation, we point out
that if CMB experiments detect a non-zero value for r, then we will immediately
obtain (as a free by-product) a new upper bound w_hat < 0.55 on the
logarithmically averaged effective equation-of-state parameter during the
``primordial dark age'' between the end of inflation and the start of BBN.Comment: v1: 12 + 6 pages (main text + appendices), 7 figures; v2: fonts fixed
in figure
22Ne and 23Na ejecta from intermediate-mass stars: The impact of the new LUNA rate for 22Ne(p,gamma)23Na
We investigate the impact of the new LUNA rate for the nuclear reaction NeNa on the chemical ejecta of intermediate-mass stars, with particular focus on the thermally-pulsing asymptotic giant branch (TP-AGB) stars that experience hot-bottom burning. To this aim we use the PARSEC and COLIBRI codes to compute the complete evolution, from the pre-main sequence up to the termination of the TP-AGB phase, of a set of stellar models with initial masses in the range , and metallicities , , and . We find that the new LUNA measures have much reduced the nuclear uncertainties of the Ne and Na AGB ejecta, which drop from factors of to only a factor of few for the lowest metallicity models. Relying on the most recent estimations for the destruction rate of Na, the uncertainties that still affect the Ne and Na AGB ejecta are mainly dominated by evolutionary aspects (efficiency of mass-loss, third dredge-up, convection). Finally, we discuss how the LUNA results impact on the hypothesis that invokes massive AGB stars as the main agents of the observed O-Na anti-correlation in Galactic globular clusters. We derive quantitative indications on the efficiencies of key physical processes (mass loss, third dredge-up, sodium destruction) in order to simultaneously reproduce both the Na-rich, O-poor extreme of the anti-correlation, and the observational constraints on the CNO abundance. Results for the corresponding chemical ejecta are made publicly available
Theoretical investigations of a highly mismatched interface: the case of SiC/Si(001)
Using first principles, classical potentials, and elasticity theory, we
investigated the structure of a semiconductor/semiconductor interface with a
high lattice mismatch, SiC/Si(001). Among several tested possible
configurations, a heterostructure with (i) a misfit dislocation network pinned
at the interface and (ii) reconstructed dislocation cores with a carbon
substoichiometry is found to be the most stable one. The importance of the slab
approximation in first-principles calculations is discussed and estimated by
combining classical potential techniques and elasticity theory. For the most
stable configuration, an estimate of the interface energy is given. Finally,
the electronic structure is investigated and discussed in relation with the
dislocation array structure. Interface states, localized in the heterostructure
gap and located on dislocation cores, are identified
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