Zawartość metali ciężkich oraz wskaźniki biochemiczne w liściach brzozy z terenów zanieczyszczonych i czystych

There were conducted studies concerning accumulation of heavy metals (Fe, Zn, Cd and Pb) in Betula pendula Roth. leaves, in surface soil within cities of Silesian and Małopolska District. Additionally, there was studied guaiacol peroxidase activity and content of -SH groups. Concentrations of heavy metals in birch leaves in most cases did not exceed permissible values. There was noticed an increased Zn content (above 100 mg/kg d.m.) in Betula pendula Roth. leaves on the all studied stands of Silesia. Accumulation of Fe, Zn, Cd and Pb in soils of the Silesian cities often exceeded the permissible level. The conducted studies showed that there is a positive correlation between Zn accumulation in white birch leaves and its accumulation in surface soil. There were not noticed significant differences in content of non-protein -SH groups and guaiacol peroxidase activity in Betula pendula ROTH. leaves coming from Silesia and Małopolska District

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearance of unfolded proteins to altered mitochondrial dynamics and apoptosis. While connections between the triggering of the unfolded protein response (UPR) and downstream mitochondrial dysfunction are poorly understood, the membranous contacts between the ER and mitochondria, called the mitochondria-associated membrane (MAM), could provide a functional link between these two mechanisms. Therefore, we investigated whether the guanosine triphosphatase (GTPase) Rab32, a known regulator of the MAM, mitochondrial dynamics, and apoptosis, could be associated with ER stress as well as mitochondrial dysfunction.This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site

Commercialization of fatherhood. The relationship of the father with the child against the background of marketing activities

The last decades brought us dynamic changes in patterns of fatherhood. It is related both to expectations toward men, and their daily functioning itself. However, the role of a father is less often commercialized than the role of a mother. In line with that, commercials and marketing activities are less often addressed to fathers than to mothers. This paper is addressed to the potential grounds of this state of affairs, and the description of the new phenomenon – dadvertising. The possible manners of profiling marketing activities including fathers as primary recipients will be presented and discussed concerning findings of studies from the field of family psychology, sociology of the family, and a few existing studies aimed at commercials addressed to fathers. The abovementioned issues will be illustrated by examples of single commercials and marketing campaigns, in which protagonists or recipients were fathers

Polska wersja kwestionariusza do badania świadomości tożsamości narracyjnej

Artykuł jest sprawozdaniem prac nad polską adaptacją kwestionariusza do badania świadomości tożsamości narracyjnej (Awareness of Narrative Identity Questionnaire, ANIQ). Samoświadomość własnej tożsamości narracyjnej jest traktowana jako zdolność metapoznawcza, która dotyczy rozumienia, że życiowe doświadczenia mogą być reprezentowane jako opowieść o Ja i postrzegania własnych wspomnień autobiograficznych jako spójnych czasowo, przyczynowo i tematycznie. Przedstawiono właściwości psychometryczne kwestionariusza, określono jego rzetelność, trafność wewnętrzną, opisano trafność kryterialną oraz stabilność test-retest. Aby określić zakresy równoważności narzędzi, porównano uzyskane wyniki z tymi uzyskanymi przy stosowaniu wersji oryginalnej. Właściwości psychometryczne uprawomocniają korzystanie z polskiej wersji narzędzia w badaniach naukowych oraz rozpoczęcie porównań międzykulturowych

Beta Blockers with Statins May Decrease All-Cause Mortality in Patients with Cardiovascular Diseases and Locally Advanced Unresectable Non-Small-Cell Lung Cancer after Chemoradiotherapy

The study was conducted in the era when maintenance immunotherapy with durvalumab was not available in clinical practice after chemoradiotherapy (CRT) in unresectable non-small-cell lung cancer (NSCLC). The main aim of the study was to check whether the presence of cardiovascular diseases (CVD) and their pharmacotherapy affects the overall survival (OS) in such NSCLC patients undergoing sequential CRT. The group of 196 patients were analyzed: 101 patients with CVD (51.53%) and 95 patients with other reasons of qualification for sequential CRT (decreased performance status, older age, and other non-cardiovascular co-morbidities). Although patients with CVD were more often in older age, and they more often experienced cardiac and nephrological complications (p p = 0.047), three (HR = 0.33; 95%CI: 0.13–0.81; p = 0.015) and even four (HR = 0.45; 95%CI: 0.22–0.97; p = 0.027) years of follow-up. The benefit in OS remained significant in 101 patients with CVD treated with beta-blockers (HR = 0.65; 95%CI: 0.43–0.99; p = 0.045), and eventually statin, throughout the whole follow-up (log-rank p < 0.05). Further prospective studies are necessary to confirm the role of beta-blockers and statins in reduction of mortality in NSCLC patients undergoing radical CRT

Additional file 1: of Rab32 connects ER stress to mitochondrial defects in multiple sclerosis

Information about origin of samples used for immunohistochemistry studies (Fig. 2G–L). Sample type refers to phenotype of isolated tissue as described in Methods. (JPG 810 kb

Additional file 2: of Rab32 connects ER stress to mitochondrial defects in multiple sclerosis

Control brain (A) shown CD68-positive (+ve) microglia (blue gray) but negative for Rab32 staining (brown). (B) Neurofilaments (blue gray) negative for Rab32 (brown). Bar = 50 μm. (JPG 1132 kb