ASSESSMENT OF THE CURRENT STATE OF THE AGRICULTURAL STRUCTURE OF ARGENTINA

Background. Argentina is one of the largest and most developed socio-economic countries in Latin America. The use of modern agricultural technologies in the Argentine plains and new methods of shipping allowed Argentina to start exporting agricultural products to Europe. A series of commodity booms enriched Argentina and made it one of the largest economies in the world at the beginning of the 20th century. Purpose is to analyze and identify problems and prospects for the development of the agricultural structure in Argentina. Materials and methods. In the study, the authors used analytical materials of the UN Economic Commission and other international organizations on the countries of Latin America, reviews and reports of the Central Bank, the Institute of Statistics, the Ministry of Economy and Public Finance, the Ministry of Foreign Affairs. In this work, dialectical, systemic, historical, logical, formal-legal, comparative research methods were used. Results. Due to the abundance of appropriate land and natural resources, the favorable climate in most of the country and the generally low activity of pests, agricultural in Argentina is not particularly limited by natural conditions. However, there are a number of other factors that prevent Argentine farmers from fully operating as efficiently as possible. Conclusion. Argentina’s agro-industrial policy is quite contradictory. Despite the development of digital services and modern information technologies to support agricultural producers, the introduction of progressive export support programs, a fairly powerful infrastructure throughout the entire production cycle of agricultural products, the Argentine government from time to time resorts to using serious export barriers to maintaining the domestic market, which in general affects the Agar sector is not always positive

Records of sika deer Cervus nippon from the southern Kuril Islands in 1986-2019, with special reference to a continuous record of living deer on Kunashir Island since 2017

The sika deer (Cervus nippon) is native to eastern Asia and commonly occurs on Hokkaido Island, northern Japan. The nearby localities of the southern Kuril Islands, located cast of Hokkaido, have not been regarded as part of the sika deer's regular range, despite isolated observations and trace evidence described before 2017. Here we consolidate the information of the sika deer in the southern Kuril Islands since 1986 with new information that establishes a continuous record of living sika deer on Kunashir Island from 2017 to 2019

Active Region Overheating in Pulsed Quantum Cascade Lasers: Effects of Nonequilibrium Heat Dissipation on Laser Performance

Mid IR Quantum cascade lasers are of high interest for the scientific community due to their unique applications. However, the QCL designs require careful engineering to overcome some crucial disadvantages. One of them is active region (ARn) overheating, which significantly affects laser characteristics, even in the pulsed mode. In this work, we consider the effects related to the nonequilibrium temperature distribution when thermal resistance formalism is irrelevant. We employ the heat equation and discuss the possible limitations and structural features stemming from the chemical composition of the ARn. We show that the presence of solid solutions in the ARn structure fundamentally limits the heat dissipation in pulsed and CW regimes due to their low thermal conductivity compared with binary compounds. Also, the QCL postgrowths affect the thermal properties of a device closer to CW mode, while it is by far less important in the short-pulsed mode

Pediatric encephalopathy: cinical, biochemical and cellular insights into the role of Gln52 of GNAO1 and GNAI1 for the dominant disease

Heterotrimeric G proteins are immediate transducers of G protein-coupled receptors—the biggest receptor family in metazoans—and play innumerate functions in health and disease. A set of de novo point mutations in GNAO1 and GNAI1, the genes encoding the α-subunits (Gαo and Gαi1, respectively) of the heterotrimeric G proteins, have been described to cause pediatric encephalopathies represented by epileptic seizures, movement disorders, developmental delay, intellectual disability, and signs of neurodegeneration. Among such mutations, the Gln52Pro substitutions have been previously identified in GNAO1 and GNAI1. Here, we describe the case of an infant with another mutation in the same site, Gln52Arg. The patient manifested epileptic and movement disorders and a developmental delay, at the onset of 1.5 weeks after birth. We have analyzed biochemical and cellular properties of the three types of dominant pathogenic mutants in the Gln52 position described so far: Gαo[Gln52Pro], Gαi1[Gln52Pro], and the novel Gαo[Gln52Arg]. At the biochemical level, the three mutant proteins are deficient in binding and hydrolyzing GTP, which is the fundamental function of the healthy G proteins. At the cellular level, the mutants are defective in the interaction with partner proteins recognizing either the GDP-loaded or the GTP-loaded forms of Gαo. Further, of the two intracellular sites of Gαo localization, plasma membrane and Golgi, the former is strongly reduced for the mutant proteins. We conclude that the point mutations at Gln52 inactivate the Gαo and Gαi1 proteins leading to aberrant intracellular localization and partner protein interactions. These features likely lie at the core of the molecular etiology of pediatric encephalopathies associated with the codon 52 mutations in GNAO1/GNAI1