39 research outputs found
HSV suppression reduces seminal HIV-1 levels in HIV-1/HSV-2 co-infected men who have sex with men.
OBJECTIVES: Suppressive herpes simplex virus (HSV) therapy can decrease plasma, cervical, and rectal HIV-1 levels in HIV-1/HSV-2 co-infected persons. We evaluated the effect of HSV-2 suppression on seminal HIV-1 levels. DESIGN: Twenty antiretroviral therapy (ART)-naive HIV-1/HSV-2 men who have sex with men (MSM) in Lima, Peru, with CD4 >200 cells/microl randomly received valacyclovir 500 mg twice daily or placebo for 8 weeks, then the alternative regimen for 8 weeks after a 2-week washout. Peripheral blood and semen specimens were collected weekly. Anogenital swab specimens for HSV DNA were self-collected daily and during clinic visits. METHODS: HIV-1 RNA was quantified in seminal and blood plasma by TaqMan real-time polymerase chain reaction (RT-PCR) or Roche Amplicor Monitor assays. HSV and seminal cytomegalovirus (CMV) were quantified by RT-PCR. Linear mixed models examined differences within participants by treatment arm. RESULTS: Median CD4 cell count of participants was 424 cells/microl. HIV-1 was detected in 71% of 231 semen specimens. HSV was detected from 29 and 4.4% of swabs on placebo and valacyclovir, respectively (P < 0.001). Valacyclovir significantly reduced the proportion of days with detectable seminal HIV-1 (63% during valacyclovir vs. 78% during placebo; P = 0.04). Seminal HIV-1 quantity was 0.25 log10 copies/ml lower [95% confidence interval (CI) -0.40 to -0.10; P = 0.001] during the valacyclovir arm compared with placebo, a 44% reduction. CD4 cell count (P = 0.32) and seminal cellular CMV quantity (P = 0.68) did not predict seminal plasma HIV-1 level. CONCLUSIONS: Suppressive valacyclovir reduced seminal HIV-1 levels in HIV-1/HSV-2 co-infected MSM not receiving ART. The significance of this finding will be evaluated in a trial with HIV-1 transmission as the outcome
Recent collisional history of (65803) Didymos
The Double Asteroid Redirection Test (DART, NASA) spacecraft revealed that the primary of the (65803) Didymos near-Earth asteroid (NEA) binary system is not exactly the expected spinning top shape observed for other km-size asteroids. Ground based radar observations predicted that such shape was compatible with the uncertainty along the direction of the asteroid spin axis. Indeed, Didymos shows crater and landslide features, and evidence for boulder motion at low equatorial latitudes. Altogether, the primary seems to have undergone sudden structural failure in its recent history, which may even result in the formation of the secondary. The high eccentricity of Didymos sets its aphelion distance inside the inner main belt, where it spends more than 1/3 of its orbital period and it may undergo many more collisions than in the NEA region. In this work, we investigate the collisional environment of this asteroid and estimate the probability of collision with multi-size potential impactors. We analyze the possibility that such impacts produced the surface features observed on Didymos by comparing collisional intervals with estimated times for surface destabilization by the Yarkovsky-O’Keefe-Radzievskii-Paddack (YORP) effect. We find that collisional effects dominate over potential local or global deformation due to YORP spin up.Project (PGC 2021) PID2021-125883NB-C21, by MICINN (Spanish Government): A.C.B., L.M.P., P.G.B. Call 2023 of the Italian National Institute for Astrophysics (INAF, act n. 38/2023): A.D.O. ESA funding through the Science Faculty—Funding reference ESA-SCI-SC-LE-191: P.G.B. “Margarita Salas” postdoctoral grant by the Spanish Ministry of University—NextGenerationEU: L.M.P. CIAPOS/2022/066 postdoctoral grant (European Social Fund. Generalitat Valenciana): L.M.P. Italian Space Agency (ASI) funding within the LICIACube project (ASI-INAF agreement n. 2019-31-HH.0): A.L., M.P. HERA project (ASI-INAF agreement n. 2022-8-HH.0): A.L., M.P
Hydroxychloroquine to prevent SARS-CoV-2 infection among healthcare workers: early termination of a phase 3, randomised, open-label, controlled clinical trial
OBJECTIVE: To assess the effectiveness and safety of hydroxychloroquine (HCQ) prophylaxis for the prevention of SARS-CoV-2 infection in healthcare workers (HCW) on duty during the COVID-19 pandemic. RESULTS: A total of 68 HCWs met the eligibility criteria were randomly allocated to receive HCQ (n = 36) or not (n = 32). There were no significant differences between groups in respects to age, gender, or medical history. Eight participants met the primary efficacy endpoint of SAR-CoV-2 infection during the study period; there was no difference in incidence of SARS-CoV-2 infections between both study arms (HCQ: 5 vs Control: 3, p = 0.538). The relative risk of SARS-CoV-2 infection in the HCQ arm was 1.69 compared to the control group (95%CI 0.41-7.11, p = 0.463); due to poor participant accrual, the resulting statistical power of the primary efficacy outcome was 11.54%. No serious adverse events occurred; however, two (2/36, 5.6%) participants no longer wished to participate in the study and withdrew consent due to recurring grade 1 and 2 adverse events. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT04414241. (Registered on June 4, 2020)
Comparison of the Virological Response According to the Antiretroviral Regimens in Peruvian HIV Patients Who Presented the M184V Mutation in Two National Hospitals during the Years 2008 to 2019
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.Introduction: In patients with HIV in antiretroviral treatment (ART) and virological failure to the first-line regimen, establishing a therapeutic regimen after having identified the M184V mutation, which confers ART resistance, represents a dilemma. Objective: To compare the virological response of the therapeutic regimens prescribed to patients with HIV who presented the M184V mutation in two national hospitals in Lima, Peru, during the years 2008 to 2019, and to determine the risk factors associated with poor virological response. Methods: A retrospective cohort study was developed based on the information of the HIV program participants with the M184V mutation. Results: A total of 175 participants were eligible for the study. The male sex predominated (75.4%), the current median age was 41 years [interquartile range (IQR) 35.84-47.47], and the time on ART was 89 months (IQR 57.7-124.53). The median initial viral load (VL) was 4.5 log10 copies/mL (IQR 3.97-5.09) and the time between genotyping and the change of therapy was 2 months (IQR 0-3.56). The most used antiretroviral regimen was protease inhibitor plus two nucleoside reverse transcriptase inhibitors (55.4%). With the protease inhibitor plus integrase inhibitor (PI + INI) ART, 69% less risk of poor virological response was obtained [p = .019 (confidence interval 95% 0.117-0.825)]. Conclusions: In patients with HIV and the M184V mutation, the PI + INI ART has shown a greater decrease in control VL and, thus, a good virological response. The risk factors associated with a poor virological response were the delay between genotyping and change of therapy, high levels of initial VL, and poor adherence among the participants.Revisión por pare
Results on Drug Resistance Mutations in Patients with HIV Who Failed First-Line Antiretroviral Therapy in a Public Hospital in Lima, Peru, 2008–2018
Carta a las Editoras sobre el artĂculo: CaracterĂsticas Sociodemográficas de IndĂgenas en los Censos Brasileños de 2000 y 2010: Un Enfoque Comparativo Abordagem Comparativa
Carta al editorRevisiĂłn por pare
Letter to the Editors regarding the paper: Sociodemographic Characteristics of Indigenous Population According to the 2000 and 2010 Brazilian Demographic Censuses: A Comparative Approach
Letter to the editors regarding the paper: Prognostic factors in HIV-positive patients with non-Hodgkin lymphoma: a Peruvian experience
Abstract Non-Hodgkin Lymphoma (NHL) is a neoplasm associated with a group of malignancies called AIDs-Defining Malignancies (ADMs) in Human-Immunodeficiency Virus (HIV) -patients. Similar to the case of NHL in Latin America, particularly in Peru, the amount of research done on others ADMs is limited, especially in the case of Kaposi’s Sarcoma (KS). Prior investigations have talked about the great potential risk that represents this illness in latin american population, but topics as prognosis factors are yet to be well defined. In this letter, we address the importance of investigation in this area and include previously reported data that may enlighten the current national standpoint
Letter to the Editors regarding the paper: Sociodemographic Characteristics of Indigenous Population According to the 2000 and 2010 Brazilian Demographic Censuses: A Comparative Approach
Carta al editorRevisiĂłn por pare