Sustainable synthesis of enantiopure fluorolactam derivatives by a selective direct fluorination – amidase strategy

Pharmaceutically important chiral fluorolactam derivatives bearing a fluorine atom at a stereogenic centre were synthesized by a route involving copper catalyzed selective direct fluorination using fluorine gas for the construction of the key C–F bond and a biochemical amidase process for the crucial asymmetric cyclisation stage. A comparison of process green metrics with reported palladium catalyzed enantioselective fluorination methodology shows the fluorination-amidase route to be very efficient and more suitable for scale-up

The influence of team emotional intelligence climate on conflict and team members' reactions to conflict

The authors seek to advance research on conflict and emotions by integrating features of conflict, reactions to conflict, and team emotional intelligence climate. They tested hypothesized links between variables with data collected from 528 employees in 97 organizational teams. Results revealed that teams with less-well-defined emotional intelligence climates were associated with increased task and relationship conflict and increased conflict intensity. In addition, team emotional intelligence climate, especially conflict management norms, moderated the link between task conflict and destructive reactions to conflict. Implications for future research and practice are discussed