Imaging X-ray spectrometer

An X-ray spectrometer for providing imaging and energy resolution of an X-ray source is described. This spectrometer is comprised of a thick silicon wafer having an embedded matrix or grid of aluminum completely through the wafer fabricated, for example, by thermal migration. The aluminum matrix defines the walls of a rectangular array of silicon X-ray detector cells or pixels. A thermally diffused aluminum electrode is also formed centrally through each of the silicon cells with biasing means being connected to the aluminum cell walls and causes lateral charge carrier depletion between the cell walls so that incident X-ray energy causes a photoelectric reaction within the silicon producing collectible charge carriers in the form of electrons which are collected and used for imaging

Towards a grapho-phonologically parsed corpus of medieval Scots:Database design and technical solutions

This paper presents a newly constructed corpus of sound-to-spelling mappings in medieval Scots, which stems from the work of the From Inglis to Scots (FITS) project. We have developed a systematic approach to the relationships between individual spellings and proposed sound values, and recorded these mutual links in a relational database. In this paper, we introduce the theoretical underpinnings of sound-to-spelling and spelling-to-sound mappings, and show how a Scots root morpheme undergoes grapho-phonological parsing, the analytical procedure that is employed to break down spelling sequences into sound units. We explain the data collection and annotation for the FITS Corpus (Alcorn et al., forthcoming), drawing attention to the extensive meta-data which accompany each analysed unit of spelling and sound. The database records grammatical and lexical information about the root, the positional arrangement of segments within the root, labels for the nuclei, vowels and consonants, the morphological context, and extra-linguistic detail of the text a given root was taken from (date, place and text type). With this wealth of information, the FITS corpus is capable of answering complex queries about the sound and spelling systems of medieval Scots. We also suggest how our methodology can be transferred to other non-standardised spelling systems

GI Bleeding in the Elderly

Purpose: To determine the risk factors contributing to and etiologies of gastrointestinal bleeding in an elderly patient population seen by Southwest Gastroenterology (SWGA) providers. Methods: This study reviews charts of patients with GI bleeding from documented sources between 1/1999 and 3/2006. The cases are gathered retrospectively from the clinical records of SWGA, a 12-person private, single specialty gastroenterology group serving community hospitals. Etiology and risk factors for GI hemorrhages are recorded in an elderly population, defined as patients age 55 and older. Results: GI hemorrhages are identified in 105 patients. The majority (83, 79%) of hemorrhages are upper GI bleeds (UGIB) comparing to 22 (21%) lower GI bleeds (LGIB). In the UGIB group, the most common etiology of bleed is gastric ulcer (29%). We also found 72% of UGIB patients on prescribed anticoagulation medications, including anti-platelet agents or non-steroidal anti-inflammatory drugs (NSAIDs). 20% of these patients are also positive for H. Pylori. Thirty patients in the UGIB group smoke or consume alcohol heavily (consuming more than 3 drinks per day for men and two drinks per day for women) while 2 patients smoke or consume alcohol in the LGIB group. Previous bleeds are common in both groups with 39 (41%) in UGIB and 9 (47%) in LGIB. Co-morbidity is the most common risk factor with 20 (91%) in LGIB and 73 (88%) in UGIB. In the peptic ulcer disease (PUD) bleeds, the majority (77%) are taking NSAIDs, while in the non-PUD bleeds, only 38% are currently on NSAIDs. Overall, there are 2 mortalities resulting from cardiovascular complications of GI bleeding. Conclusion: The etiologies of GI bleeds in this population are comparable to other studies in the literature. The ratio of UGIB to LGIB in this elderly population is also similar to that reported in the literature. The risk factors shown to be most correlated to bleeding are co-morbidities, previous episodes of bleeding, anticoagulation, NSAID use, smoking and alcohol use. NSAID use is significant in PUD bleed patients. This study reinforces that increased knowledge of etiology, incidence and contributing factors of GI bleeding are necessary for physicians to efficiently treat GI bleeds in the elderly population

Galaxy Merger Fractions in Two Clusters at Z ∼ 2 Using the Hubble Space Telescope

We measure the fraction of galaxy-galaxy mergers in two clusters at z ,F∼ ,F2 using imaging and grism observations from the Hubble Space Telescope. The two galaxy cluster candidates were originally identified as overdensities of objects using deep mid-infrared imaging and observations from the Spitzer Space Telescope, and were subsequently followed up with HST/WFC3 imaging and grism observations. We identify galaxy-galaxy merger candidates using high-resolution imaging with the WFC3 in the F105W, F125W, and F160W bands. Coarse redshifts for the same objects are obtained with grism observations in G102 for the z ,F∼ ,F1.6 cluster (IRC0222A) and G141 for the z ,F∼ ,F2 cluster (IRC0222B). Using visual classifications as well as a variety of selection techniques, we measure merger fractions of in IRC0222A and in IRC0222B. In comparison, we measure a merger fraction of for field galaxies at z ,F∼ ,F2. Our study indicates that the galaxy-galaxy merger fraction in clusters at z ,F∼ ,F2 is enhanced compared to the field population, but note that more cluster measurements at this epoch are needed to confirm our findings

Measurement of the Condensation Coefficient of Water in the UMR Cloud Simulation Chamber

Measurements of the condensation coefficient of water under conditions closely approximating those in natural atmospheric cloud have been made in the cooled-wall UMR cloud simulation chamber. Current measurements disclose a value of condensation coefficient near unity at the outset of the experiment, generally decreasing to lower values (~ .01) as the experiment progresses. The significance of the magnitude of condensation coefficient in atmospheric cloud is briefly discussed

MOSEL: Strong [OIII]5007 \AA\ Emitting Galaxies at (3<z<4) from the ZFOURGE Survey

To understand how strong emission line galaxies (ELGs) contribute to the overall growth of galaxies and star formation history of the universe, we target Strong ELGs (SELGs) from the ZFOURGE imaging survey that have blended (Hb+[OIII]) rest-frame equivalent widths of >230A and 2.5<zphot<4.0. Using Keck/MOSFIRE, we measure 49 redshifts for galaxies brighter than Ks=25 mag as part of our Multi-Object Spectroscopic Emission Line (MOSEL) survey. Our spectroscopic success rate is ~53% and zphot uncertainty is sigma_z= [Delta(z)/(1+z)]=0.0135. We confirm 31 ELGs at 3<zspec<3.8 and show that Strong ELGs have spectroscopic rest-frame [OIII]5007A equivalent widths of 100-500A and tend to be lower mass systems [log(Mstar/Msun)~8.2-9.6] compared to more typical star-forming galaxies. The Strong ELGs lie ~0.9 dex above the star-forming main-sequence at z~3.5 and have high inferred gas fractions of fgas~>60%, i.e. the inferred gas masses can easily fuel a starburst to double stellar masses within ~10-100 Myr. Combined with recent results using ZFOURGE, our analysis indicates that 1) strong [OIII]5007A emission signals an early episode of intense stellar growth in low mass (Mstar<0.1M*) galaxies and 2) many, if not most, galaxies at z>3 go through this starburst phase. If true, low-mass galaxies with strong [OIII]5007A emission (EW_rest>200A) may be an increasingly important source of ionizing UV radiation at z>3.Comment: Astrophysical Journal, in pres

Electromagnetic Meson Production in the Nucleon Resonance Region

Recent experimental and theoretical advances in investigating electromagnetic meson production reactions in the nucleon resonance region are reviewed.Comment: 75 pages, 42 figure

The Endogenous Th17 Response in NO<inf>2</inf>-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer

Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO2) is an environmental toxin that correlates with asthma severity, exacerbation, and risk of adverse outcomes. Mice that are allergically sensitized to the antigen ovalbumin by exposure to NO2 exhibit a mixed Th2/Th17 adaptive immune response and eosinophil and neutrophil recruitment to the airway following antigen challenge, a phenotype reminiscent of severe clinical asthma. Because IL-1 receptor (IL-1R) signaling is critical in the generation of the Th17 response in vivo, we hypothesized that the IL-1R/Th17 axis contributes to pulmonary inflammation and airway hyperresponsiveness (AHR) in NO2-promoted allergic airway disease and manifests in glucocorticoid-resistant cytokine production. IL-17A neutralization at the time of antigen challenge or genetic deficiency in IL-1R resulted in decreased neutrophil recruitment to the airway following antigen challenge but did not protect against the development of AHR. Instead, IL-1R-/- mice developed exacerbated AHR compared to WT mice. Lung cells from NO2-allergically inflamed mice that were treated in vitro with dexamethasone (Dex) during antigen restimulation exhibited reduced Th17 cytokine production, whereas Th17 cytokine production by lung cells from recipient mice of in vitro Th17-polarized OTII T-cells was resistant to Dex. These results demonstrate that the IL-1R/Th17 axis does not contribute to AHR development in NO2-promoted allergic airway disease, that Th17 adoptive transfer does not necessarily reflect an endogenously-generated Th17 response, and that functions of Th17 responses are contingent on the experimental conditions in which they are generated. © 2013 Martin et al