Câncer de colo de útero: atenção enquanto jovem para prevenção na terceira idade / Cervical cancer: attention while young for prevention in old age

OBJETIVO: Evidenciar a importância dos exames preventivos para detectar doenças em estágios iniciais e destacar a importância da educação em saúde para que esses procedimentos tenham sua devida seriedade notada pela população na luta contra o câncer cervical. RESULTADOS: O câncer de colo de útero é o terceiro câncer mais comum na população feminina brasileira, sendo causado em grande parte por alguns subtipos de HPV, causando infecções crônicas e levando a neoplasia. Essa doença é prevenida primariamente por meio da cobertura vacinal de HPV, obtenção de conhecimento sobre relações sexuais seguras, educação em saúde voltada para mudança de estilo de vida e realização do exame Papanicolau. CONCLUSÃO: O enfermeiro é o principal agente de realização de prevenção e proteção de HPV e câncer de colo de útero, agindo diretamente com a educação em mulheres mais jovens para evitar o acometimento da doença em idades mais avançadas

Práxica de enfermagem em saúde coletiva: Vivência acadêmica na atenção primária à saúde

Resumo: Objetivou-se descrever as experiências obtidas por meio de ações extensionistas no âmbito da saúde materno-infantil, fundamentada na Teoria de Intervenção Práxica de Enfermagem em Saúde Coletiva. Trata-se de um relato de experiência realizado em uma unidade básica de saúde da região norte do Ceará. A implementação da teoria tornou viável a compreensão da realidade objetiva formadora daquele território, bem como a elaboração de um planejamento baseado nas subjetividades da população. Tais ações repercutiram diretamente na organização da unidade e proporcionaram a reativação do grupo de puericultura, a construção de conhecimentos por meio dos momentos de promoção e educação em saúde, assim como a contribuição para a formação dos acadêmicos de enfermagem, enquanto futuros profissionais. As experiências obtidas implicam diretamente na ressignificação das abordagens grupais, com destaque para o âmbito materno-infantil, como também estimulam a visão holística e o pensamento crítico por parte dos acadêmicos. Palavras-chave: Saúde Materno-Infantil; Saúde Pública; Teoria de Enfermagem; Universidade; Extensão Comunitária   Nursing Praxical in Collective Health: Academic Experience in Primary Health Care Abstract: The objective was to describe the experiences obtained through extension actions in maternal and child health scope based on the Theory of Praxis Intervention in Public Health Nursing. This paper is an experience report carried out in a primary health unit in the northern region of Ceará (Brazil). The theory implementation made it possible to understand the objective reality that formed that territory, as well as to elaborate a plan based on the population’s subjectivities. Such actions had a direct impact on the organization of the unit. They provided the childcare group reactivation, knowledge building through moments of health promotion and education, and contribution to training nursing students as future professionals. The experiences obtained directly imply the redefinition of group approaches, emphasizing the maternal-child scope and the stimulation of a holistic view and critical thinking by nursing academics. Keywords: University Maternal and Child Health; Public Health; Nursing Theory; Universities; Community-Institutional Relation

Selenylated Imidazo[1,2<i>-a</i>]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells

Imidazo[1,2-a]pyridines (IPs) have been studied regarding drug development. The objective of this work was to evaluate the antileukemic capacity of IP derivatives by screening their ability as a pro-oxidant. IP derivatives were synthesized and oral bioavailability and toxicity were analyzed in silico. Redox screening was performed on human Kasumi, KG-1, K562, and Jurkat leukemia cells. The IP derivative and the most responsive leukemic cell were selected for cytotoxicity, cell proliferation, cell senescence, and oxidative stress assays. The predictive toxicity analysis showed a possible effect on the reproductive system, but without mutagenic, carcinogenic, or irritability effects. MRK-107 against K562 cells was the compound that showed the best redox profile. MRK-107 did not induce cell death in K562 and monocyte cells. However, this compound was able to decrease cell proliferation and increase cell senescence after 48 and 72 h. Furthermore, MRK-107 induced oxidative stress in K562 cells after 72 h, increasing lipid peroxidation and decreasing reduced glutathione (GSH) contents. This study demonstrated that MRK-107-induced senescence with the involvement of oxidative stress is a possible mechanism of action, addressing this compound as a potential antitumor drug against chronic myeloid leukemia

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, 10 anteaters, and 6 sloths. Our data set includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the southern United States, Mexico, and Caribbean countries at the northern portion of the Neotropics, to the austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n = 5,941), and Cyclopes sp. have the fewest (n = 240). The armadillo species with the most data is Dasypus novemcinctus (n = 11,588), and the fewest data are recorded for Calyptophractus retusus (n = 33). With regard to sloth species, Bradypus variegatus has the most records (n = 962), and Bradypus pygmaeus has the fewest (n = 12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other data sets of Neotropical Series that will become available very soon (i.e., Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans data set. Please cite this data paper when using its data in publications. We also request that researchers and teachers inform us of how they are using these data

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data