Operations and Performance of the PACS Instrument 3He Sorption Cooler on board of the Herschel Space Observatory

A 3He sorption cooler produced the operational temperature of 285mK for the bolometer arrays of the Photodetector Array Camera and Spectrometer (PACS) instrument of the Herschel Space Observatory. This cooler provided a stable hold time between 60 and 73h, depending on the operational conditions of the instrument. The respective hold time could be determined by a simple functional relation established early on in the mission and reliably applied by the scientific mission planning for the entire mission. After exhaustion of the liquid 3He due to the heat input by the detector arrays, the cooler was recycled for the next operational period following a well established automatic procedure. We give an overview of the cooler operations and performance over the entire mission and distinguishing in-between the start conditions for the cooler recycling and the two main modes of PACS photometer operations. As a spin-off, the cooler recycling temperature effects on the Herschel cryostat 4He bath were utilized as an alternative method to dedicated Direct Liquid Helium Content Measurements in determining the lifetime of the liquid Helium coolant.Comment: 34 pages, 13 figures, accepted in Experimental Astronom

Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling

Background: Mild therapeutic hypothermia following cardiac arrest is neuroprotective, but its effect on myocardial dysfunction that is a critical issue following resuscitation is not clear. This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological postconditioning are cardioprotective in a model of cardiopulmonary resuscitation following acute myocardial ischemia. Methodology/Principal Findings: Thirty pigs (28–34 kg) were subjected to cardiac arrest following left anterior descending coronary artery ischemia. After 7 minutes of ventricular fibrillation and 2 minutes of basic life support, advanced cardiac life support was started according to the current AHA guidelines. After successful return of spontaneous circulation (n = 21), coronary perfusion was reestablished after 60 minutes of occlusion, and animals were randomized to either normothermia at 38°C, hypothermia at 33°C or hypothermia at 33°C combined with sevoflurane (each group n = 7) for 24 hours. The effects on cardiac damage especially on inflammation, apoptosis, and remodeling were studied using cellular and molecular approaches. Five animals were sham operated. Animals treated with hypothermia had lower troponin T levels (p<0.01), reduced infarct size (34±7 versus 57±12%; p<0.05) and improved left ventricular function compared to normothermia (p<0.05). Hypothermia was associated with a reduction in: (i) immune cell infiltration, (ii) apoptosis, (iii) IL-1beta and IL-6 mRNA up-regulation, and (iv) IL-1beta protein expression (p<0.05). Moreover, decreased matrix metalloproteinase-9 activity was detected in the ischemic myocardium after treatment with mild hypothermia. Sevoflurane conferred additional protective effects although statistic significance was not reached. Conclusions/Significance: Hypothermia reduced myocardial damage and dysfunction after cardiopulmonary resuscitation possible via a reduced rate of apoptosis and pro-inflammatory cytokine expression