170 research outputs found
Quantities, determinants, and awareness of households' food waste in Italy: A comparison between diary and questionnaires quantities
Food waste at the household level accounts for a significant share of total food waste in developed economies, according to the Food and Agriculture Organization. Studies have shown that this share varies between 0.3 kg to 4.5 kg per person per week, depending on the definitions and methodologies applied. In Italy, quantities, behaviors, and attitudes regarding food waste have been solely explored through the use of questionnaires, typically leading to discrepant values of food waste. In this study, we estimate and analyse the determinants of food waste over a 388 units' panel spread over the national territory, through a diary and questionnaire study. Moreover, by comparing food waste value that was declared in questionnaires and reported in diaries, we confirm that the awareness of food waste quantities is heavily biased. The results confirm that the average food waste value is significantly higher when gathered through diaries, while questionnaires are able to catch less than one-third of food waste determinants
Deciphering the central immunomodulatory effects of a vortioxetine pretreatment on the LPS-induced inflammatory cascade
The proinflammatory cytokine interleukin 18 regulates feeding by acting on the bed nucleus of the stria terminalis
The proinflammatory cytokine IL-18 has central anorexigenic effects and was proposed to contribute to loss of appetite observed during sickness. Here we tested in the mouse the hypothesis that IL-18 can decrease food intake by acting on neurons of the bed nucleus of the stria terminalis (BST), a component of extended amygdala recently shown to influence feeding via its projections to the lateral hypothalamus (LH). We found that both subunits of the heterodimeric IL-18 receptor are highly expressed in the BST and that local injection of recombinant IL-18 (50 ng/ml) significantly reduced c-fos activation and food intake for at least 6 h. Electrophysiological experiments performed in BST brain slices demonstrated that IL-18 strongly reduces the excitatory input on BST neurons through a presynaptic mechanism. The effects of IL-18 are cell-specific and were observed in Type III but not in Type I/II neurons. Interestingly, IL-18-sensitve Type III neurons were recorded in the juxtacapsular BST, a region that contains BST-LH projecting neurons. Reducing the excitatory input on Type III GABAergic neurons, IL-18 can increase the firing of glutamatergic LH neurons through a disinhibitory mechanism. Imbalance between excitatory and inhibitory activity in the LH can induce changes in food intake. Effects of IL-18 were mediated by the IL-18R because they were absent in neurons from animals null for IL-18Rα (Il18ra-/-), which lack functional IL-18 receptors. In conclusion, our data show that IL-18 may inhibit feeding by inhibiting the activity of BST Type III GABAergic neurons
Gli studenti EIDI al tempo del coronavirus. Risultati della rilevazione online del 21 marzo 2020
Questo rapporto di ricerca presenta i risultati della prima rilevazione di monitoraggio online delle condizioni di vita e di studio degli studenti di Economia e Istituzioni dei Distretti industriali (2019-20) di Unimore (rilevazione on line del 21 marzo 2020). Il monitoraggio on line, che si svolgerà periodicamente fino alla fine del corso (lezioni e esami) è un esperimento di collaborazione che mira a superare l’emergenza covid-19 con maggiore consapevolezza e strumenti per praticare una didattica e uno studio che contribuiscano nel dare a ciascuno studente la possibilità di studiare e procedere nel proprio percorso di studi e di vita nel migliore dei modi. Vengono presentati il questionario, gli strumenti di rilevazione e i risultati che emergono da una prima elaborazione dei dati. Il rapporto si conclude con spunti per la prossima rilevazione e proposte per allargare la rilevazione. Le specifiche proposte didattiche e di studio che sono emerse anche grazie al primo monitoraggio non sono presentate in questo rapporto: sono in continua evoluzione e sono condivise con gli studenti nella piattaforma online del corso
Syncope: experience at a tertiary care hospital in Karachi, Pakistan
Introduction:Our aim was to determine the characteristics of Patients presenting with syncope at a tertiary care hospital in Karachi, Pakistan.Methods: A review of medical records was conducted retrospectively at the Department of Medicine, Aga Khan University Hospital, Karachi. Patients aged 16 and above, admitted from January 2000 to December 2005 with the diagnosis of syncope made by the attending physician were included.Results:A total of 269 Patients were included (75% males, mean age: 57.4 years). Neurogenic (vasovagal) syncope was the most common cause (47%), followed by cardiogenic syncope (18%) and orthostatic syncope (9%). A total of 24% were discharged undiagnosed. Twenty Patients (7.4%) did not have any prodrome. Common prodromal symptoms included dizziness (61%), sweating (25%), palpitations (19%), nausea/vomiting (19%) and visual symptoms (17%). The distribution of symptoms according to cause of syncope revealed only breathlessness to be significantly associated with cardiogenic syncope (p = 0.002). Most Patients with cardiogenic syncope were aged above 40 (98%, p \u3c 0.001), had coronary artery disease (72%, p \u3c 0.001) and abnormal electrocardiogram at presentation (92%, p \u3c 0.001).Conclusion:Despite differences in burden of diseases, our findings were similar to those of published syncope literature. Further studies are needed to develop a protocol to expedite the evaluation and limit the work-up and admission in low-risk Patients
The main actors involved in parasitization of Heliothis virescens larva
At the moment of parasitization by another insect, the host Heliothis larva is able to defend itself by the activation of humoral and cellular defenses characterized by unusual reactions of hemocytes in response to external stimuli. Here, we have combined light and electron microscopy, staining reactions, and immunocytochemical characterization to analyze the activation and deactivation of one of the most important immune responses involved in invertebrates defense, i.e., melanin production and deposition. The insect host/parasitoid system is a good model to study these events. The activated granulocytes of the host insect are a major repository of amyloid fibrils forming a lattice in the cell. Subsequently, the exocytosed amyloid lattice constitutes the template for melanin deposition in the hemocel. Furthermore, cross-talk between immune and neuroendocrine systems mediated by hormones, cytokines, and neuromodulators with the activation of stress-sensoring circuits to produce and release molecules such as adrenocorticotropin hormone, alpha melanocyte-stimulating hormone, and neutral endopeptidase occurs. Thus, parasitization promotes massive morphological and physiological modifications in the host insect hemocytes and mimics general stress conditions in which phenomena such as amyloid fibril formation, melanin polymerization, pro-inflammatory cytokine production, and activation of the adrenocorticotropin hormone system occur. These events observed in invertebrates are also reported in the literature for vertebrates, suggesting that this network of mechanisms and responses is maintained throughout evolution
Stratospheric HBr concentration profile obtained from far-infrared emission spectroscopy
Hydrogen bromide (HBr) is the principal bromine sink species for the ozone loss chemistry induced by bromine‐containing gases in the stratosphere. We report a 1994 balloon‐based measurement of the daytime stratospheric HBr profile between 20 and 36.5 km altitude. The average concentration result of 1.31±0.39 parts per trillion in volume (pptv) and an analysis for the concentration versus altitude profile are consistent with previously reported measurements. These results strengthen the evidence for a significantly higher HBr concentration than that predicted by current photochemical models which, on the basis of recent kinetics results, do not include significant HBr production by the reaction branch, BrO + HO2 → HBr + O3
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