Court Monitoring Program of the Victoria Status of Women Action Group

This article discusses the creation and successful implementation of a project that monitors court cases involving violent crimes against women and children. This initiative offers a two-way bridge between grassroots activism and feminist theorizing.Cet article traite de la création et de la réalisation couronnée de succès d'un projet qui suit de près les procès au tribunal qui ont trait aux crimes violents commis contre des femmes et des enfants. Cette initiative permet un rapprochement entre l'activisme de base et l'élaboration de théories féministes

Predicting occupational strain and job satisfaction: the role of stress, coping, personality, and affectivity variables

Four studies employed path analysis to examine how measures of occupational stressors, coping resources, and negative affectivity (NA) and positive affectivity (PA) interact to predict occupational strain. The Occupational Stress Inventory (Osipow & Spokane, 1987) was used to measure stress, strain, and coping. The Positive and Negative Affectivity Schedule (Watson, Clark, & Tellegen, 1988) was used for the affectivity variables. The hypothesised model showed NA and PA as background dispositional variables that influenced relations among stress, strain, and coping while still allowing stress and coping to have a direct influence on strain. Goodness of fit indices were acceptable with the model predicting 15 per cent of the variance in stress, 24 per cent of coping, and 70 per cent of strain. Study 2 replicated these findings. Study 3 added a positive outcome variable, job satisfaction (JSI: Brayfield & Rothe, 1951) to the model. The expanded model again fit the data well. A fourth study added a global measure of personality (NEO-FFI: Costa & McCrae, 1991) to the model tested in Study 3. Results indicated that personality measures did not add anything to the prediction of job satisfaction and strain in a model that already included measures of stressors, coping resources, NA and PA. The series of four studies yielded a reliable structural model that highlights the influence of organizational and dispositional variables on occupational strain and job satisfaction

Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System

In an attempt to increase selectivity vs Cathepsin D (CatD) in our BACE1 program, a series of 1,3,4,4a,10,10a-hexahydropyrano­[4,3-b]­chromene analogues was developed. Three different Asp-binding moieties were examined: spirocyclic acyl guanidines, aminooxazolines, and aminothiazolines in order to modulate potency, selectivity, efflux, and permeability. Using structure-based design, substitutions to improve binding to both the S3 and S2′ sites of BACE1 were explored. An acyl guanidine moiety provided the most potent analogues. These compounds demonstrated 10–420 fold selectivity for BACE1 vs CatD, and were highly potent in a cell assay measuring Aβ_1–40 production (5–99 nM). They also suffered from high efflux. Despite this undesirable property, two of the acyl guanidines achieved free brain concentrations (C_free,brain) in a guinea pig PD model sufficient to cover their cell IC₅₀s. Moreover, a significant reduction of Aβ_1–40 in guinea pig, rat, and cyno CSF (58%, 53%, and 63%, respectively) was observed for compound <b>62</b>