4,748 research outputs found
Reducing model uncertainty effects in flexible manipulators through the addition of passive damping
An important issue in the control of practical systems is the effect of model uncertainty on closed loop performance. This is of particular concern when flexible structures are to be controlled, due to the fact that states associated with higher frequency vibration modes are truncated in order to make the control problem tractable. Digital simulations of a single-link manipulator system are employed to demonstrate that passive damping added to the flexible member reduces adverse effects associated with model uncertainty. A controller was designed based on a model including only one flexible mode. This controller was applied to larger order systems to evaluate the effects of modal truncation. Simulations using a Linear Quadratic Regulator (LQR) design assuming full state feedback illustrate the effect of control spillover. Simulations of a system using output feedback illustrate the destabilizing effect of observation spillover. The simulations reveal that the system with passive damping is less susceptible to these effects than the untreated case
Comparison of joint space versus task force load distribution optimization for a multiarm manipulator system
It is often proposed that the redundancy in choosing a force distribution for multiple arms grasping a single object should be handled by minimizing a quadratic performance index. The performance index may be formulated in terms of joint torques or in terms of the Cartesian space force/torque applied to the body by the grippers. The former seeks to minimize power consumption while the latter minimizes body stresses. Because the cost functions are related to each other by a joint angle dependent transformation on the weight matrix, it might be argued that either method tends to reduce power consumption, but clearly the joint space minimization is optimal. A comparison of these two options is presented with consideration given to computational cost and power consumption. Simulation results using a two arm robot system are presented to show the savings realized by employing the joint space optimization. These savings are offset by additional complexity, computation time and in some cases processor power consumption
Molecular Electroporation and the Transduction of Oligoarginines
Certain short polycations, such as TAT and polyarginine, rapidly pass through
the plasma membranes of mammalian cells by an unknown mechanism called
transduction as well as by endocytosis and macropinocytosis. These
cell-penetrating peptides (CPPs) promise to be medically useful when fused to
biologically active peptides. I offer a simple model in which one or more CPPs
and the phosphatidylserines of the inner leaflet form a kind of capacitor with
a voltage in excess of 180 mV, high enough to create a molecular electropore.
The model is consistent with an empirical upper limit on the cargo peptide of
40--60 amino acids and with experimental data on how the transduction of a
polyarginine-fluorophore into mouse C2C12 myoblasts depends on the number of
arginines in the CPP and on the CPP concentration. The model makes three
testable predictions.Comment: 15 pages, 5 figure
Ribosome recycling induces optimal translation rate at low ribosomal availability
Funding statement The authors thank BBSRC (BB/F00513/X1, BB/I020926/1 and DTG) and SULSA for funding. Acknowledgement The authors thank R. Allen, L. Ciandrini, B. Gorgoni and P. Greulich for very helpful discussions and careful reading of the manuscript.Peer reviewedPublisher PD
Shelby\u27s Expedition to Mexico: An Unwritten Leaf of the War
Migration to Mexico Ex-Confederates moved from one Civil War to another Most Civil War readers are aware that various parties of ex-Confederates migrated to Mexico shortly after the end of the Civil War. The common assumption may very well be that these immigrants or would-be ...
Mean encounter times for cell adhesion in hydrodynamic flow: analytical progress by dimensional reduction
For a cell moving in hydrodynamic flow above a wall, translational and
rotational degrees of freedom are coupled by the Stokes equation. In addition,
there is a close coupling of convection and diffusion due to the
position-dependent mobility. These couplings render calculation of the mean
encounter time between cell surface receptors and ligands on the substrate very
difficult. Here we show for a two-dimensional model system how analytical
progress can be achieved by treating motion in the vertical direction by an
effective reaction term in the mean first passage time equation for the
rotational degree of freedom. The strength of this reaction term can either be
estimated from equilibrium considerations or used as a fit parameter. Our
analytical results are confirmed by computer simulations and allow to assess
the relative roles of convection and diffusion for different scaling regimes of
interest.Comment: Reftex, postscript figures include
Filamin cross-linked semiflexible networks: Fragility under strain
The semiflexible F-actin network of the cytoskeleton is cross-linked by a
variety of proteins including filamin, which contain Ig-domains that unfold
under applied tension. We examine a simple semiflexible network model
cross-linked by such unfolding linkers that captures the main mechanical
features of F-actin networks cross-linked by filamin proteins and show that
under sufficiently high strain the network spontaneously self-organizes so that
an appreciable fraction of the filamin cross-linkers are at the threshold of
domain unfolding. We propose an explanation of this organization based on a
mean-field model and suggest a qualitative experimental signature of this type
of network reorganization under applied strain that may be observable in
intracellular microrheology experiments of Crocker et al.Comment: 4 Pages, 3 figures, Revtex4, submitted to PR
Dynamics of non-equilibrium membrane bud formation
The dynamical response of a lipid membrane to a local perturbation of its
molecular symmetry is investigated theoretically. A density asymmetry between
the two membrane leaflets is predominantly released by in-plane lipid diffusion
or membrane curvature, depending upon the spatial extent of the perturbation.
It may result in the formation of non-equilibrium structures (buds), for which
a dynamical size selection is observed. A preferred size in the micrometer
range is predicted, as a signature of the crossover between membrane and
solvent dominated dynamical membrane response.Comment: 7 pages 3 figure
Effects of Sequence Disorder on DNA Looping and Cyclization
Effects of sequence disorder on looping and cyclization of the
double-stranded DNA are studied theoretically. Both random intrinsic curvature
and inhomogeneous bending rigidity are found to result in a remarkably wide
distribution of cyclization probabilities. For short DNA segments, the range of
the distribution reaches several orders of magnitude for even completely random
sequences. The ensemble averaged values of the cyclization probability are also
calculated, and the connection to the recent experiments is discussed.Comment: 8 pages, 4 figures, LaTeX; accepted to Physical Review E; v2: a
substantially revised version; v3: references added, conclusions expanded,
minor editorial corrections to the text; v4: a substantially revised and
expanded version (total number of pages doubled); v5: new Figure 4, captions
expanded, minor editorial improvements to the tex
- …