14 research outputs found
CANNABIS SATIVA L. EVALUACIÓN Y POTENCIALIDAD COMO MEDICAMENTO
El abuso y consumo lúdico de la planta de Cannabis, sumado a su carácter ilegal, generaron en la sociedad numerosos prejuicios que tergiversaron sus verdaderos potenciales farmacológicos y dificultaron la investigación científica en nuestro país. Por esa razón debían vencerse no solo los obstáculos sino también las resistencias personales de investigadores, autoridades e instituciones. El proyecto que aquí se difunde pretende contextualizar un uso de estos productos científicamente avalado, que evite las vías alternativas actuales de producción y dispensación, sin la asistencia o intervención de un profesional farmacéutico, que puedan promover resultados perjudiciales para los pacientes. Es imprescindible, entonces, un marco normativo que otorgue un contexto de seguridad y un correcto manejo
CYCLIZATION PROCEDURES TOWARD THE SYNTHESIS OF SOME CONFORMATIONALLY RESTRICTED NITROGEN HETEROCYCLES
Semicarbazones and copper complexes of semicarbazones and thiosemicarbazones derived from 1-indanones: synthesis, structure and spectroscopy
Efficient microwave-assisted esterification reaction employing methanesulfonic acid supported on alumina as catalyst
A rapid and efficient protocol assisted by microwave irradiation for the synthesis of esters using methanesulfonic acid (CH3SO3H) supported on Al2O3 (AMA) as catalyst and free of solvent is described. The products were obtained in good yields and purity, with reduced reaction time, and the process is simple and environmentally benign.Fil: Fabian, Lucas Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Gómez, Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Caturelli Kuran, Juan Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Moltrasio, Graciela Yolanda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Moglioni, Albertina Gladys. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Divergent Routes to Chiral Cyclobutane Synthons from (−)-α-Pinene and Their Use in the Stereoselective Synthesis of Dehydro Amino Acids
Antibacterial and antifungal activity of some thiosemicarbazones and 1,3,4-thiadiazolines
Synthesis of New Indanyl Nucleoside Analogues and their Biological Evaluation on Hepatitis C Virus (HCV) Replicon
Here, we report a convenient synthetic procedure for the preparation of four novel indanyl carbanucleoside derivatives in the racemic form. The action of these compounds against hepatitis C virus was evaluated in vitro using the replicon cell line, Huh7.5 SG. Contrary to our expectations, all these compounds did not inhibit, but rather promoted HCV genotype 1b (HCVg1b) replication. Similar effects have been reported for morphine in the replicon cell lines, Huh7 and Huh8. Several biological experiments and computational studies were performed to elucidate the effect of these compounds on HCVg1b replication. Based on all the experiments performed, we propose that the increase in HCVg1b replication could be mediated, at least in part, by a similar mechanism to that of morphine on the enhancement of this replication. The presence of opioid receptors in Huh7.5 SG cells was indirectly determined for the first time in this work