Effect of a Training Program on Hepatic Fat Content and Cardiometabolic Risk in Postmenopausal Women: The Randomized Controlled Trial

Abstract: This 10-week randomized controlled trial investigates the effects of two different training modalities on hepatic fat content and cardiometabolic risk in sedentary postmenopausal women. Besides, alterations in physical fitness, hepatic fat content, and cardiometabolic risk will be associated with changes in those blood parameters that are usually modifiable by exercise training. Postmenopausal women ( n = 32; ~61 years) were randomly assigned to one of the following treatment groups; (1) based on international exercise recommendations (EX group; n = 16), (2) exercise plus whole-body electromyostimulation (EX+EMS group; n = 16). Cardiometabolic risk score was calculated based on the international diabetes federation’s clinical criteria. Hepatic fat content was estimated using the fatty liver index. After the intervention, the cardiometabolic risk and the fatty liver index decreased, showing a higher impact on EX + WB-EMS. Physical fitness was assessed through aerobic and strength tests belonging to “Eurofit Testing Battery”. In all of them, significant differences were observed (p < 0.001), though EX+ EMS experienced better improvements (p < 0.05). In conclusion, a 10-week exercise training program, especially with WB-EMS, triggered improvements in physical fitness and reduced cardiometabolic risk and hepatic fat content in sedentary postmenopausal women.Funding: This study was funded by the non-profit organization: Institut de Desenvolupament Social i Territorial. Universitat de Lleida. The name of this project is “Active aging, quality of live and intergenerational relationships”. Grant INDEST2016. Institutional Review Board Statement: The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Ethics Committee of Arnau of Vilanova University Hospital, Lléida, (Spain) (CEIC-1701)

Bioactive compounds derived from the yeast metabolism of aromatic amino acids during alcoholic fermentation

Metabolites resulting from nitrogen metabolism in yeast are currently found in some fermented beverages such as wine and beer. Their study has recently attracted the attention of researchers. Some metabolites derived from aromatic amino acids are bioactive compounds that can behave as hormones or even mimic their role in humans and may also act as regulators in yeast. Although the metabolic pathways for their formation are well known, the physiological significance is still far from being understood. The understanding of this relevance will be a key element in managing the production of these compounds under controlled conditions, to offer fermented food with specific enrichment in these compounds or even to use the yeast as nutritional complement

Encephalitis due to rabies secondary to the bite of a cat infected with a rabies virus of silvester origen

La rabia es una enfermedad viral zoonótica, producida por un virus del genero Lyssavirus de la Familia Rhabdoviridae, cuya principal fuente de transmisión es la mordedura de animales a humanos. Es una enfermedad fatal y se han descrito casos por ciclos urbanos y rurales. El caso que reportamos es el de una joven de 22 años, quien ingresa por un cuadro de dolor de características neuropáticas en el miembro superior derecho, con antecedente de mordedura por un gato de varios meses atrás, hospitalizada por el servicio de Neurología por sospecha de lesión de plejo braquial, con resonancia de columna cervical y líquido cefalorraquídeo (LCR) normales, quien posteriormente presenta deterioro clínico tórpido a un proceso encefalopático que en pocos días la llevó a la muerte. Se confirmó que la paciente presentó una encefalitis por un virus de rabia. Expondremos cómo fue el manejo de la paciente y todos los nexos epidemiológicos.Q1Reporte de caso167-170Rabies is a zoonotic viral disease, caused by a virus of the genus Lyssavirus of the Rhabdoviridae family. Its main source is transmission from animals to humans bite. The disease is fatal and has been reported to occur in rural and urban cycles. This reported case is a 22-year old, who was admitted with symptoms of neuropathic pain in the right arm, with a history of being bitten by a cat a few months earlier. The patient was hospitalized in the Neurology Department for suspected brachial plexopathy, and normal spinal MRI and cerebrospinal fluid (CSF) were found. The patient subsequently presented encephalopathic decline that resulted in death within a few days. It was confirmed that the patient had encephalitis due to the rabies virus. We present the management of the patient and all epidemiological links

Study of Beauty Hadron Decays into Pairs of Charm Hadrons

First observations of the decays Λ 0 b → Λ + c D − ( s ) are reported using data corresponding to an integrated luminosity of 3     fb − 1 collected at 7 and 8 TeV center-of-mass energies in proton-proton collisions with the LHCb detector. In addition, the most precise measurement of the branching fraction B ( B 0 s → D + D − s ) is made and a search is performed for the decays B 0 ( s ) → Λ + c Λ − c . The results obtained are B ( Λ 0 b → Λ + c D − ) / B ( Λ 0 b → Λ + c D − s ) = 0.042 ± 0.003 ( stat) ± 0.003 ( syst ) , [ B ( Λ 0 b → Λ + c D − s ) B ( ¯ B 0 → D + D − s ) ] / [ B ( Λ 0 b → Λ + c π − ) B ( ¯ B 0 → D + π − ) ] = 0.96 ± 0.02 ( stat) ± 0.06 ( syst) , B ( B 0 s → D + D − s ) / B ( ¯ B 0 → D + D − s ) = 0.038 ± 0.004 ( stat) ± 0.003 ( syst) , B ( ¯ B 0 → Λ + c Λ − c ) / B ( ¯ B 0 → D + D − s ) < 0.0022 [ 95 %     C . L . ] , B ( B 0 s → Λ + c Λ − c ) / B ( B 0 s → D + D − s ) < 0.30 [ 95 %     C . L . ] . Measurement of the mass of the Λ 0 b baryon relative to the ¯ B 0 meson gives M ( Λ 0 b ) − M ( ¯ B 0 ) = 339.72 ± 0.24 ( stat ) ± 0.18 ( syst)     MeV / c 2 . This result provides the most precise measurement of the mass of the Λ 0 b baryon to date

Measurement of resonant and CP components in ¯B0s → J/ψπ+π− decays

Structure of the decay ¯ B 0 s → J / ψ π + π − is studied using data corresponding to 3   fb − 1 of integrated luminosity from p p collisions produced by the LHC and collected by the LHCb detector. Five interfering π + π − states are required to describe the decay: f 0 ( 980 ) , f 0 ( 1500 ) , f 0 ( 1790 ) , f 2 ( 1270 ) , and f ′ 2 ( 1525 ) . An alternative model including these states and a nonresonant J / ψ π + π − component also provides a good description of the data. Based on the different transversity components measured for the spin-2 intermediate states, the final state is found to be compatible with being entirely C P odd. The C P -even part is found to be < 2.3 % at a 95% confidence level. The f 0 ( 500 ) state is not observed, allowing a limit to be set on the absolute value of the mixing angle with the f 0 ( 980 ) of < 7. 7 ∘ at a 90% confidence level, consistent with a tetraquark interpretation of the f 0 ( 980 ) substructure

First measurement of time-dependent CP violation in B0s→K+K− decays

Direct and mixing-induced CP-violating asymmetries in B0s→K+K− decays are measured for the first time using a data sample of pp collisions, corresponding to an integrated luminosity of 1.0 fb−1, collected with the LHCb detector at a centre-of-mass energy of 7 TeV. The results are C KK  = 0.14 ± 0.11 ± 0.03 and S KK  = 0.30 ± 0.12 ± 0.04, where the first uncertainties are statistical and the second systematic. The corresponding quantities are also determined for B 0 → π + π − decays to be C ππ  = −0.38 ± 0.15 ± 0.02 and S ππ  = −0.71 ± 0.13 ± 0.02, in good agreement with existing measurements

Study of B0(s)→K0Sh+h′− decays with first observation of B0s→K0SK±π∓ and B0s→K0Sπ+π

A search for charmless three-body decays of B 0 and B0s mesons with a K0S meson in the final state is performed using the pp collision data, corresponding to an integrated luminosity of 1.0 fb−1, collected at a centre-of-mass energy of 7 TeV recorded by the LHCb experiment. Branching fractions of the B0(s)→K0Sh+h′− decay modes (h (′) = π, K), relative to the well measured B0→K0Sπ+π− decay, are obtained. First observation of the decay modes B0s→K0SK±π∓ and B0s→K0Sπ+π− and confirmation of the decay B0→K0SK±π∓ are reported. The following relative branching fraction measurements or limits are obtained $ B(B0→K0SK±π∓)B(B0→K0Sπ+π−)=0.128±0.017(stat.)±0.009(syst.),B(B0→K0SK+K−)B(B0→K0Sπ+π−)=0.385±0.031(stat.)±0.023(syst.),B(B0s→K0Sπ+π−)B(B0→K0Sπ+π−)=0.29±0.06(stat.)±0.03(syst.)±0.02(fs/fd),B(B0s→K0SK±π∓)B(B0→K0Sπ+π−)=1.48±0.12(stat.)±0.08(syst.)±0.12(fs/fd)B(B0s→K0SK+K−)B(B0→K0Sπ+π−)∈[0.004;0.068]at90%CL

Studies of beauty baryon decays to D0ph− and Λ+ch− final states

Decays of beauty baryons to the D 0 p h − and Λ + c h − final states (where h indicates a pion or a kaon) are studied using a data sample of p p collisions, corresponding to an integrated luminosity of 1.0     fb − 1 , collected by the LHCb detector. The Cabibbo-suppressed decays Λ 0 b → D 0 p K − and Λ 0 b → Λ + c K − are observed, and their branching fractions are measured with respect to the decays Λ 0 b → D 0 p π − and Λ 0 b → Λ + c π − . In addition, the first observation is reported of the decay of the neutral beauty-strange baryon Ξ 0 b to the D 0 p K − final state, and a measurement of the Ξ 0 b mass is performed. Evidence of the Ξ 0 b → Λ + c K − decay is also reported

Observation of the Decay B+c→B0sπ+

The result of a search for the decay B + c → B 0 s π + is presented, using the B 0 s → D − s π + and B 0 s → J / ψ ϕ channels. The analysis is based on a data sample of p p collisions collected with the LHCb detector, corresponding to an integrated luminosity of 1     fb − 1 taken at a center-of-mass energy of 7 TeV, and 2     fb − 1 taken at 8 TeV. The decay B + c → B 0 s π + is observed with significance in excess of 5 standard deviations independently in both decay channels. The measured product of the ratio of cross sections and branching fraction is [ σ ( B + c ) / σ ( B 0 s ) ] × B ( B + c → B 0 s π + ) = [ 2.37 ± 0.31   ( stat ) ± 0.11   ( syst ) + 0.17 − 0.13 ( τ B + c ) ] × 10 − 3 , in the pseudorapidity range 2 < η ( B ) < 5 , where the first uncertainty is statistical, the second is systematic, and the third is due to the uncertainty on the B + c lifetime. This is the first observation of a B meson decaying to another B meson via the weak interaction

Search for the Lepton-Flavor-Violating Decays Bs0→e±μ∓ and B0→e±μ∓

A search for the lepton-flavor-violating decays B 0 s → e ± μ ∓ and B 0 → e ± μ ∓ is performed with a data sample, corresponding to an integrated luminosity of 1.0     fb − 1 of p p collisions at √ s = 7     TeV , collected by the LHCb experiment. The observed number of B 0 s → e ± μ ∓ and B 0 → e ± μ ∓ candidates is consistent with background expectations. Upper limits on the branching fractions of both decays are determined to be B ( B 0 s → e ± μ ∓ ) 101     TeV / c 2 and M LQ ( B 0 → e ± μ ∓ ) > 126     TeV / c 2 at 95% C.L., and are a factor of 2 higher than the previous bounds