2,644 research outputs found

    ClĂĄsicos de la administraciĂłn pĂșblica

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    Quasi-linear simulations of inner radiation belt electron pitch angle and energy distributions

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    “Peculiar” or “butterfly” electron pitch angle distributions (PADs), with minima near 90°, have recently been observed in the inner radiation belt. These electrons are traditionally treated by pure pitch angle diffusion, driven by plasmaspheric hiss, lightning-generated whistlers, and VLF transmitter signals. Since this leads to monotonic PADs, energy diffusion by magnetosonic waves has been proposed to account for the observations. We show that the observed PADs arise readily from two-dimensional diffusion at L = 2, with or without magnetosonic waves. It is necessary to include cross diffusion, which accounts for the relationship between pitch angle and energy changes. The distribution of flux with energy is also in good agreement with observations between 200 keV and 1 MeV, dropping to very low levels at higher energy. Thus, at this location radial diffusion may be negligible at subrelativistic as well as ultrarelativistic energy

    RNAi for Western Corn Rootworm Management: Lessons Learned, Challenges, and Future Directions

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    The western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, is considered one of the most economically important pests of maize (Zea mays L.) in the United States (U.S.) Corn Belt with costs of management and yield losses exceeding USD ~1–2 billion annually. WCR management has proven challenging given the ability of this insect to evolve resistance to multiple management strategies including synthetic insecticides, cultural practices, and plant-incorporated protectants, generating a constant need to develop new management tools. One of the most recent developments is maize expressing double-stranded hairpin RNA structures targeting housekeeping genes, which triggers an RNA interference (RNAi) response and eventually leads to insect death. Following the first description of in planta RNAi in 2007, traits targeting multiple genes have been explored. In June 2017, the U.S. Environmental Protection Agency approved the first in planta RNAi product against insects for commercial use. This product expresses a dsRNA targeting the WCR snf7 gene in combination with Bt proteins (Cry3Bb1 and Cry34Ab1/Cry35Ab1) to improve trait durability and will be introduced for commercial use in 2022

    Oral Health Quality Improvement in the Era of Accountability

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    The purpose of this report is to review the current status and trends in quality measurement and improvement and describe efforts underway to expand and enhance those efforts. The report will also describe opportunities to use emerging oral health measurement and quality improvement systems to improve and maintain the oral health of the U.S. population

    Principles and principals: Do customer stewardship and agency control compete or complement when shaping frontline employee behavior?

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    This article introduces customer stewardship control (CSC) to the marketing field. This concept represents a frontline employee's felt ownership of and moral responsibility for customers' overall welfare. In two studies, the authors show that CSC is a more encompassing construct than customer orientation, which reflects a frontline employee's focus on meeting customers' needs. They provide evidence that the former is more potent in shaping in- and extra-role employee behaviors. Moreover, they highlight how CSC operates in conjunction with an organization's agency control system: Stewardship's positive influence on in- and extra-role behavior is weaker in the presence of high agency control. They offer actionable advice about how to solve the resulting managerial control dilemma. Finally, the authors show that CSC depends on drivers that reside at the individual level (employee relatedness), the team level (team competence), or both levels of aggregation (employee and team autonomy). These findings show how to effectively design a frontline employee's work environment to ensure optimal frontline performance

    The Relationship Between Central Auditory Tests and Neurocognitive Domains in Adults Living With HIV

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    Objective: Tests requiring central auditory processing, such as speech perception-in-noise, are simple, time efficient, and correlate with cognitive processing. These tests may be useful for tracking brain function. Doing this effectively requires information on which tests correlate with overall cognitive function and specific cognitive domains. This study evaluated the relationship between selected central auditory focused tests and cognitive domains in a cohort of normal hearing adults living with HIV and HIV– controls. The long-term aim is determining the relationships between auditory processing and neurocognitive domains and applying this to analyzing cognitive function in HIV and other neurocognitive disorders longitudinally. Method: Subjects were recruited from an ongoing study in Dar es Salaam, Tanzania. Central auditory measures included the Gap Detection Test (Gap), Hearing in Noise Test (HINT), and Triple Digit Test (TDT). Cognitive measures included variables from the Test of Variables of Attention (TOVA), Cogstate neurocognitive battery, and Kiswahili Montreal Cognitive Assessment (MoCA). The measures represented three cognitive domains: processing speed, learning, and working memory. Bootstrap resampling was used to calculate the mean and standard deviation of the proportion of variance explained by the individual central auditory tests for each cognitive measure. The association of cognitive measures with central auditory variables taking HIV status and age into account was determined using regression models. Results: Hearing in Noise Tests and TDT were significantly associated with Cogstate learning and working memory tests. Gap was not significantly associated with any cognitive measure with age in the model. TDT explained the largest mean proportion of variance and had the strongest relationship to the MoCA and Cogstate tasks. With age in the model, HIV status did not affect the relationship between central auditory tests and cognitive measures. Age was strongly associated with multiple cognitive tests. Conclusion: Central auditory tests were associated with measures of learning and working memory. Compared to the other central auditory tests, TDT was most strongly related to cognitive function. These findings expand on the association between auditory processing and cognitive domains seen in other studies and support evaluating these tests for tracking brain health in HIV and other neurocognitive disorders

    A new ionospheric electron precipitation module coupled with RAM-SCB within the geospace general circulation model

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    Electron precipitation down to the atmosphere due to wave-particle scattering in the magnetosphere contributes significantly to the auroral ionospheric conductivity. In order to obtain the auroral conductivity in global MHD models that are incapable of capturing kinetic physics in the magnetosphere, MHD parameters are often used to estimate electron precipitation flux for the conductivity calculation. Such an MHD approach, however, lacks self-consistency in representing the magnetosphere-ionosphere coupling processes. In this study we improve the coupling processes in global models with a more physical method. We calculate the physics-based electron precipitation from the ring current and map it to the ionospheric altitude for solving the ionospheric electrodynamics. In particular, we use the BATS-R-US (Block Adaptive Tree Scheme-Roe type-Upstream) MHD model coupled with the kinetic ring current model RAM-SCB (Ring current-Atmosphere interaction Model with Self-Consistent Magnetic field (B)) that solves pitch angle-dependent electron distribution functions, to study the global circulation dynamics during the 25–26 January 2013 storm event. Since the electron precipitation loss is mostly governed by wave-particle resonant scattering in the magnetosphere, we further investigate two loss methods of specifying electron precipitation loss associated with wave-particle interactions: (1) using pitch angle diffusion coefficients Dαα(E,α) determined from the quasi-linear theory, with wave spectral and plasma density obtained from statistical observations (named as “diffusion coefficient method”) and (2) using electron lifetimes τ(E) independent on pitch angles inferred from the above diffusion coefficients (named as “lifetime method”). We found that both loss methods demonstrate similar temporal evolution of the trapped ring current electrons, indicating that the impact of using different kinds of loss rates is small on the trapped electron population. However, for the precipitated electrons, the lifetime method hardly captures any precipitation in the large L shell (i.e., 4 < L < 6.5) region, while the diffusion coefficient method produces much better agreement with NOAA/POES measurements, including the spatial distribution and temporal evolution of electron precipitation in the region from the premidnight through the dawn to the dayside. Further comparisons of the precipitation energy flux to DMSP observations indicates that the new physics-based precipitation approach using diffusion coefficients for the ring current electron loss can explain the diffuse electron precipitation in the dawn sector, such as the enhanced precipitation flux at auroral latitudes and flux drop near the subauroral latitudes, but the traditional MHD approach largely overestimates the precipitation flux at lower latitudes

    Novel role of a triglyceride-synthesizing enzyme:DGAT1 at the crossroad between triglyceride and cholesterol metabolism

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    AbstractAcyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol (TG) biosynthesis. Here we show that genetic deficiency and pharmacological inhibition of DGAT1 in mice alters cholesterol metabolism. Cholesterol absorption, as assessed by acute cholesterol uptake, was significantly decreased in the small intestine and liver upon DGAT1 deficiency/inhibition. Ablation of DGAT1 in the intestine (I-DGAT1−/−) alone is sufficient to cause these effects. Consequences of I-DGAT1 deficiency phenocopy findings in whole-body DGAT1−/− and DGAT1 inhibitor-treated mice. We show that deficiency/inhibition of DGAT1 affects cholesterol metabolism via reduced chylomicron size and increased trans-intestinal cholesterol excretion. These effects are independent of cholesterol uptake at the apical surface of enterocytes but mediated through altered dietary fatty acid metabolism. Our findings provide insight into a novel role of DGAT1 and identify a pathway by which intestinal DGAT1 deficiency affects whole-body cholesterol homeostasis in mice. Targeting intestinal DGAT1 may represent a novel approach for treating hypercholesterolemia
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