Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure

A Series Of Potential Biologically Active Compounds Have Been Synthesized Through The Derivatization of Carboxyl Group In Naproxen Core Structure Involving The Conversion The Naproxen To Its Methyl Ester Then To TheAcid Hydrazide. The Acid Hydrazide Of Naproxen Was Incorporated With Hydrazones, Diamide Linkage, Oxadiazole, Pyrazolone, Triazole, Quinazoline And Indole Containing Motifs. The Targeted Compounds Have Been Achieved In A Very Good Yield Under Conventional Heat And Irradiation Conditions. All Compounds Have Been Characterized By Ir, 1h-Nmr, 13c-Nmr And Mass Spectra.Keywords: Naproxen; Anti-Inflammatory; Nsaid's

Impact of the Generation System Parameters on the Frequency Response of the Power System: A UK Grid Case Study

The operation and the development of power system networks introduce new types of stability problems. The effect of the power generation and consumption on the frequency of the power system can be described as a demand/generation imbalance resulting from a sudden increase/decrease in the demand and/or generation. This paper investigates the impact of a loss of generation on the transient behaviour of the power grid frequency. A simplified power system model is proposed to examine the impact of change of the main generation system parameters (system inertia, governor droop setting, load damping constant, and the high-pressure steam turbine power fraction), on the primary frequency response in responding to the disturbance of a 1.32 GW generation loss on the UK power grid. Various rates of primary frequency responses are simulated via adjusting system parameters of the synchronous generators to enable the controlled generators providing a fast-reliable primary frequency response within 10 s after a loss of generation. It is concluded that a generation system inertia and a governor droop setting are the most dominant parameters that effect the system frequency response after a loss of generation. Therefore, for different levels of generation loss, the recovery rate will be dependent on the changes of the governor droop setting values. The proposed model offers a fundamental basis for a further investigation to be carried on how a power system will react during a secondary frequency response

Morphological and phylogenetic study of Hyalomma anatolicum in Al-Najaf, Iraq

Studies had been previously conducted to genetically identify species of ticks in Iraq. Therefore, the current investigational study was conducted to recognize the species of 50 ticks collected from infested skin of cattle. The current study defined the ticks to be from Hyalomma genus depending on theirmorphological features. Using mitochondrial cytochrome oxidase subunit I (CoxI) gene, 16 ticks were further confirmed using polymerase chain reaction (PCR). Two PCR products were subjected to DNA sequencing to name the species of the ticks and compare them to some other known ticks in neighbor and world countries. The sequencing results identified the ticks to be Hyalomma anatolicum. One isolate is closely similar to Indian and Iranian isolates, and the other isolate is clustered alone by itself. The results indicated that H. anatolicum is one of the wide-spread ticks that affect cattle in Al Najaf province, Iraq

Design of an unmanned aircraft system for high-altitude 1 kW fuel cell power system.

A proton exchange membrane (PEM) fuel cell is particularly considered as a prime power supply for a fuel cell-powered unmanned aircraft system (UAS) as it possesses a very high-power density in comparison with other fuel cell types, hence a high potential to be used for high altitude long endurance (HALE) UAS flights. This paper will focus on examining the design requirements for the UAS-based 1 kW PEM fuel cell for high altitude operation (10–11 km), which can be correlated into a quantitative data to produce a design constraints diagram. The maximum take-off mass, endurance, and geometries for potential UAS design are estimated. Four different geometrical design profiles are developed and presented. The resulting geometries are analysed and the design parameters of the estimated 1 kW design yielded an aircraft of maximum take-off mass 34.8 kg, wingspan of 10.4 m, cruising speed 20 m/s, stall speed 11.23 m/s, and maximum endurance of 4 h. The constraint diagram deploys these assumptions as well as values generated through the design calculations to form a possible design of which the 1 kW UAS falls slightly outside of the possible design space; this is due to the minimum thrust-to-weight ratio required to achieve the desired service ceiling; however, further alterations and adjustments on the design and mission requirements are provided to place the design of the UAS within the possible design space

Assessment the Impact of Different Hydrated Lime Addition Methods on Fatigue Life Characteristic

The purpose of this study is to evaluate the effect of hydrated lime addition methods as filler replacement on fatigue performance of Hot Mix Asphalt (HMA). Three types of addition methods of hydrated lime were introduced namely dry HL on dry aggregate and saturated surface aggregate above 3% and slurry HL on dry aggregate, ordinary Lime stone powder was reduced by three HL percentage (1.0, 2.0 and 3.0 %). The effect of different methods were investigated on the fatigue properties of HMA using, third-point flexural fatigue bending Test. Pneumatic Repeated Load System (PRLS) was carried out to establish the effect of hydrated lime on the fatigue failure criteria and to select the proper hydrated lime application methods on fatigue behavior of HMA mixtures. The fatigue functions for asphalt mixture with hydrated lime are obtained and compared, and it confirm that the fatigue property of asphalt mixture can be improved using all methods and the addition methods were exhibited different optimality for the result due to its effect . The test results were carried out through the performance analysis using Vesys 5W (2003) to study the long term effectiveness of hydrated lime effect

The Evolution of X-ray Bursts in the "Bursting Pulsar" GRO J1744-28

GRO J1744-28, commonly known as the `Bursting Pulsar', is a low mass X-ray binary containing a neutron star and an evolved giant star. This system, together with the Rapid Burster (MXB 1730-33), are the only two systems that display the so-called Type II X-ray bursts. These type of bursts, which last for 10s of seconds, are thought to be caused by viscous instabilities in the disk; however the Type II bursts seen in GRO J1744-28 are qualitatively very different from those seen in the archetypal Type II bursting source the Rapid Burster. To understand these differences and to create a framework for future study, we perform a study of all X-ray observations of all 3 known outbursts of the Bursting Pulsar which contained Type II bursts, including a population study of all Type II X-ray bursts seen by RXTE. We find that the bursts from this source are best described in four distinct phenomena or `classes' and that the characteristics of the bursts evolve in a predictable way. We compare our results with what is known for the Rapid Burster and put out results in the context of models that try to explain this phenomena.Comment: Accepted to MNRAS Aug 17 201

THE TRANSITION TO A PG GRADING SYSTEM FOR ASPHALT CEMENT IN IRAQ

In Iraq, as well as many other developing countries the performance graded (PG) based System is not yet implemented to evaluate the currently used asphalt cernents for paving works. It appears that not only the unavailability of test equipments is resulting in this delay but also the lack of clear understanding of what steps could be taken to incorporate this system. This research is an attempt to highlight the important aspects of a (PG) system that can be readily implemented without the need for expensive equipments. It includes the development of a Performance based System employing the conventional test methods and available nomographs from literature. It also, shows how climatic data, traffic data, and asphalt binder properties can be combined to propose a possible major improvement for the specifications of asphalts in Iraq. To achieve the objective of this research, an extensive air temperature data for a period of 18 years was reviewed for five cities (Mosul. Kirkuk. Rutba, Baghdad, and Basrah) to establish the required PG asphalt binder for each city. Also, the currently used asphalt cements with penetration grades (40-50) and (60-70) were tested by both of conventional test methods and Superpave methods to determine the equivalent performance grade for each type of the penetration graded asphalt and to evaluate the capability for these two types of asphalt cement to satisfy the required performance of pavement for each city, The results indicate that both the new proposed method and Superpave method give the same final performance grade. The asphalt with penetration grade 40-50 is equivalent to PG70-16 while that with penetration grade 60-70 is equivalent to PG64-16

Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure

A Series of Potential Biologically Active Compounds Have Been Synthesized Through the Derivatization of Carboxyl Group in Naproxen Core Structure Involving the Conversion the Naproxen to its Methyl Ester then to the Acid Hydrazide. The Acid Hydrazide of Naproxen was incorporated with Hydrazones, Diamide Linkage, Oxadiazole, Pyrazolone, Triazole, Quinazoline and Indole Containing Motifs. The Targeted Compounds have been achieved in a very good yield under Conventional Heat and Irradiation Conditions. All Compounds have been characterized by Ir, 1h-Nmr, 13c-Nmr and Mass Spectra

Crystal structure of 4,6-diamino-2- sulfanylidene-1,2-dihydropyridine-3- carbonitrile

The title compound, C 6 H 6 N 4 S, crystallizes with two independent molecules, A and B, in the asymmetric unit. Both independent molecules are almost planar [maximum deviations of 0.068 (6) Å in molecule A and 0.079 (6) Å in molecule B]. In the crystal, molecules A and B are linked by N-HÁ Á ÁS, N-HÁ Á ÁN and C-HÁ Á ÁS hydrogen bonds, forming a threedimensional network

N-(2-Hydroxyphenyl)-4-methylbenzenesulfonamide

In the title compound, C13H13NO3S, the dihedral angle between the benzene rings is 64.15 (7)° and the C-S-N-C torsion angle is -57.18 (12)°. An intra­molecular N-H...O hydrogen bond closes an S(5) ring. In the crystal, O-H...O hydrogen bonds link the mol­ecules into C(8) chains propagating in [100]. Weak C-H...[pi] inter­actions are also observed