Environmental Stress Affects DNA Methylation of a CpG Rich Promoter Region of Serotonin Transporter Gene in a Nurse Cohort

Peer reviewe

Demographic data of the nurse groups by work stress.

<p>Demographic data of the nurse groups by work stress.</p

Representation of the <i>SLC6A4</i> gene promoter region for bisulfite sequencing analysis.

<p>Analyzed CpG sites are bolded and numbered from 1 through 5. Coordinates are based on the GRCh37 build (NCBI Reference Sequence: NC_000017.10).</p

Methylation in the promoter of <i>SLC6A4</i> at five CpG sites in high (grey) and low (white) work stress environments.

<p>Coordinates for each residue are 28 563 120 (CpG5), 28 563 109 (CpG4), 28 563 107 (CpG3), 28 563 102 (CpG2), and 28 563 090 (CpG1) as per GRCh37 build (NCBI Reference Sequence: NC_000017.10). Differences between work stress environments were significant as per t-test (p = 7.10E–06, p = 2.50E–05, p = 0.000292, p = 4.37E–06, and p = 0.000289 respectively). Standard errors are indicated.</p

Distribution of the 5-HTTLPR genotype.

<p>Distribution of the 5-HTTLPR genotype.</p