Cedrus atlantica (Endl.) Manetti ex Carrière Essential Oil Alleviates Pain and Inflammation with No Toxicity in Rodent

Cedrus atlantica (Endl.) Manetti ex Carrière is an endemic tree with spiritual value, and it was used since immemorial time in folk medicine. The present study aims to evaluate the anti-inflammatory (carrageenan-induced paw edema and formalin tests) and analgesic effects (hot plate and acetic acid writhing tests) of the cedarwood essential oil, as well as inspect any toxicity (acute toxicity), using several in vivo assays. Following the acetic acid writhing test and the hot plate test, the EO presented an excellent analgesic effect compared to the controls, especially with the dose of 50 mg/kg. Similar results were found while assessing the anti-inflammatory potential in the carrageenan-induced paw edema and formalin assays. The acute toxicity assessment and the subsequent monitoring of the animals, the biochemical analysis, and the relative organ weight, demonstrated a total safety of the EO. The GC/MS analysis of the composition revealed that the major compounds contained in this EO are beta-himachalene (51.95%), followed by alpha-himachalene (15.82%), and gamma-himachalene (12.15%). This study supports the usage of this tree EO to alleviate pain and inflammation

Cedrus atlantica (Endl.) Manetti ex Carrière Essential Oil Alleviates Pain and Inflammation with No Toxicity in Rodent

Cedrus atlantica (Endl.) Manetti ex Carrière is an endemic tree with spiritual value, and it was used since immemorial time in folk medicine. The present study aims to evaluate the anti-inflammatory (carrageenan-induced paw edema and formalin tests) and analgesic effects (hot plate and acetic acid writhing tests) of the cedarwood essential oil, as well as inspect any toxicity (acute toxicity), using several in vivo assays. Following the acetic acid writhing test and the hot plate test, the EO presented an excellent analgesic effect compared to the controls, especially with the dose of 50 mg/kg. Similar results were found while assessing the anti-inflammatory potential in the carrageenan-induced paw edema and formalin assays. The acute toxicity assessment and the subsequent monitoring of the animals, the biochemical analysis, and the relative organ weight, demonstrated a total safety of the EO. The GC/MS analysis of the composition revealed that the major compounds contained in this EO are beta-himachalene (51.95%), followed by alpha-himachalene (15.82%), and gamma-himachalene (12.15%). This study supports the usage of this tree EO to alleviate pain and inflammation

Liposuction Anaesthesia: Considerations and Techniques

This study aimed at recognizing the ultimate decision to select the type of anesthesia depends on the type and extent of the liposuction surgery planned, the patient’s underlying health condition and the psychological disposition of the patient. The study also describes the four types of liposuction techniques based on the volume of infiltration or wetting solution injected, dry, wet, superwet, and tumescent technique. Besides analyzing the main differences between these techniques and the amount of infiltration done into the tissues and the resultant blood loss as a percentage of aspirated fluid, highlighting that the tumescent technique is the most common of all liposuction techniques. The study found that liposuction is a popular procedure for reducing excessive fat from the body. It is associated with major hemodynamic changes, especially in large-volume liposuction surgery. Anaesthesia for these procedures requires a thorough understanding of the physiological changes and likely complications associated with them. Keywords: Anaesthesia, liposuction, techniques

SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts

Welcome to the Book of Abstracts for the 2019 SPARC conference. This year we not only celebrate the work of our PGRs but also our first ever Doctoral School Best Supervisor awards, which makes this year’s conference extra special. Once again we have received a tremendous contribution from our postgraduate research community; with over 90 presenters, the conference truly showcases a vibrant, innovative and collaborative PGR community at Salford. These abstracts provide a taster of the inspiring, relevant and impactful research in progress, and provide delegates with a reference point for networking and initiating critical debate. Find an abstract that interests you, and say “Hello” to the author. Who knows what might result from your conversation? With such wide-ranging topics being showcased, we encourage you to take up this great opportunity to engage with researchers working in different subject areas from your own. To meet global challenges, high impact research needs interdisciplinary collaboration. This is recognised and rewarded by all major research funders. Engaging with the work of others and forging collaborations across subject areas is an essential skill for the next generation of researchers. Even better, our free ice cream van means that you can have those conversations while enjoying a refreshing ice lolly

Design, synthesis, antitumor evaluation, and molecular docking of novel pyrrolo[2,3-d]pyrimidine as multi-kinase inhibitors

In the last twenty years, protein kinases have been identified as important targets for cancer therapy. In order to prevent unexpected toxicity, medicinal chemists have always focused on discovering selective protein kinase inhibitors. However, cancer is a multifactorial process and its formation and progression depend on different stimuli. Therefore, it is imperative to develop anticancer therapy that targets multiple kinases associated cancer progression. In this research a series of hybrid compounds was designed and synthesized successfully with the aim of producing anticancer activity through the induction of multiple protein kinase inhibition. The designed derivatives comprise isatin and pyrrolo[2,3-d]pyrimidine scaffolds in their structures with a hydrazine linking the two pharmacophores. Antiproliferative and kinase inhibition assays revealed promising anticancer and multi-kinase inhibitory effects of compound 7 with comparable results with the reference standards. Moreover, compound 7 suppressed cell cycle progression and induced apoptosis in HepG2 cells. Finally, molecular docking simulation was performed to investigate the potential types of interactions between the protein kinase enzymes and the designed hybrid compounds. The results of this research indicated the promising anticancer effect of compound 7 through the inhibition of a number of protein kinase receptors and the suppression of cell cycle and the induction of apoptosis

sj-docx-1-tps-10.1177_13634615241227691 - Supplemental material for Cultural adaptations of third-wave psychotherapies in Gulf Cooperation Council countries: A systematic review

Supplemental material, sj-docx-1-tps-10.1177_13634615241227691 for Cultural adaptations of third-wave psychotherapies in Gulf Cooperation Council countries: A systematic review by Duaa H. Alrashdi, Aisha H. Alyafei, Samar A. Alanazi, Carly Meyer, and Rebecca L. Gould in Transcultural Psychiatry</p

Hematological and biochemical parameters among obese students at the PSAU, Alkharj, KSA

Management of obesity represents a global problem that challenges the provision of healthcare services in most countries. Saudi Arabia ranked number 29 on a 2007 list of countries with 6% of its population being overweight (BMI &gt; 25).In a university setting, we studied hematological parameters (including whole blood counts, haemoglobin and platelets), the presence of basophilia, iron levels and lipid profiles in obese students, and also in non-obese student controls. We found a significant increase in whole blood count in obese compared to healthy individuals, and also found a high level of basophilia compared to healthy controls.&nbsp; We also report that the obese student group suffered from low iron levels, and also a reduced total iron binding capacity, as compared to healthy controls. Levels of cholesterol and triglycerides was significantly higher in obese students compared to healthy controls. This study can be interpreted that universities across the Kingdom, and beyond, should consider targeting obesity management in their students to try to reduce the prevalence of obesity and associated disorders, and to support such healthcare programs by offering a variety of environmental, physical exercise and nutritional interventions

Relationship between obesity and immunological parameters among students at the PSAU University-Alkharj, KSA

Obesity represents a major worldwide health problem, all aspects of which have not fully defined, nor fully understood.&nbsp; In the current study, we investigated a population of university students in terms of the relationship between incidence of obesity in individuals (n=171),within this larger cohort (n=500), with the comorbidities that these high BMI individuals also carried. We also report important statistical differences in blood levels each of cardiac-related protein (CRP)(p=0.002), IL-6(p=0.005), &amp;leptin(p=0.02), when we related the blood values with individual student BMIs which were used as a measure of obesity