123,416 research outputs found
Objective Bayes and Conditional Frequentist Inference
Objective Bayesian methods have garnered considerable interest and support among statisticians,
particularly over the past two decades. It has often been ignored, however, that in
some cases the appropriate frequentist inference to match is a conditional one. We present
various methods for extending the probability matching prior (PMP) methods to conditional
settings. A method based on saddlepoint approximations is found to be the most
tractable and we demonstrate its use in the most common exact ancillary statistic models.
As part of this analysis, we give a proof of an exactness property of a particular PMP in
location-scale models. We use the proposed matching methods to investigate the relationships
between conditional and unconditional PMPs. A key component of our analysis is a
numerical study of the performance of probability matching priors from both a conditional
and unconditional perspective in exact ancillary models. In concluding remarks we propose
many routes for future research
Invisible Friends
April 7-10 and 14-17, 1994. Written by Alan Ayckbourn. Directed by Therald F. Todd. Costume Design by Marilyn Skow. Set and Lighting Design by M. P. Amico.https://digitalcommons.fiu.edu/theatre_programs/1012/thumbnail.jp
Invisible Friends postcard
April 7-10 and 14-17, 1994. University Theatre, Viertes Haus 100. Written by Alan Ayckbourn. Directed by Therald Todd. Costume design by Marilyn R. Skow. Set design by M. P. Amico. .https://digitalcommons.fiu.edu/theatre_posters/1106/thumbnail.jp
Performing Arts Class: November 21, 1980
This is the program for the Performing Arts Class recital held on November 21, 1980, in the Mabee Fine Arts Center Recital Hall. It featured pianist Jonathan Besancon, pianist Terri Pierce, alto-sax player Tony Smith, baritone Todd Hathcock, mezzo-soprano Beth Sumpter, and baritone Alan Moore
Who\u27s Afraid of Virginia Woolf? postcard
April 13-16 and 20-23, 1989. Written by Edward Albee. Directed by Therald Todd. Costumes design by Marilyn R. Skow. Set design by Zak Herring. Starring Mary Ellen O\u27Brien as Martha; Tim Crowther as George; Maite Arnedo as Honey; Alan Schack as Nick.https://digitalcommons.fiu.edu/theatre_posters/1136/thumbnail.jp
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How can health economics be used in the design and analysis of adaptive clinical trials? A qualitative analysis
Introduction
Adaptive designs offer a flexible approach, allowing changes to a trial based on examinations of the data as it progresses. Adaptive clinical trials are becoming a popular choice, as the prudent use of finite research budgets and accurate decision-making are priorities for healthcare providers around the world. The methods of health economics, which aim to maximise the health gained for money spent, could be incorporated into the design and analysis of adaptive clinical trials to make them more efficient. We aimed to understand the perspectives of stakeholders in health technology assessments to inform recommendations for the use of health economics in adaptive clinical trials.
Methods
A qualitative study explored the attitudes of key stakeholders—including researchers, decision-makers and members of the public—towards the use of health economics in the design and analysis of adaptive clinical trials. Data were collected using interviews and focus groups (29 participants). A framework analysis was used to identify themes in the transcripts.
Results
It was considered that answering the clinical research question should be the priority in a clinical trial, notwithstanding the importance of cost-effectiveness for decision-making. Concerns raised by participants included handling the volatile nature of cost data at interim analyses; implementing this approach in global trials; resourcing adaptive trials which are designed and adapted based on health economic outcomes; and training stakeholders in these methods so that they can be implemented and appropriately interpreted.
Conclusion
The use of health economics in the design and analysis of adaptive clinical trials has the potential to increase the efficiency of health technology assessments worldwide. Recommendations are made concerning the development of methods allowing the use of health economics in adaptive clinical trials, and suggestions are given to facilitate their implementation in practice
How the Other Half Loves (1996) | Program
Performed: 15-19 March 1996; Alan Ayckbourn\u27s How the Other Half Loves was presented as part of the Kaleidoscope Arts Festival. The men from three couples all work for the same firm. The youngest man is having an affair with the oldest man\u27s wife. A cover-up is invented. The play was student directed by Todd and Mishia Edwards, stage managed by Rene Humphrey, scenic design by Todd Edwards, costume design/poster & program design by Deborah Johnson, lighting design by Chris Collins, technical direction by David Keefer, produced by Carlton Ward, faculty costume advisor was Freddy Clements, faculty directing advisor was Wayne H. Claeren. This item is contained within the Clements drama production materials.https://digitalcommons.jsu.edu/productions_all/1173/thumbnail.jp
Seeing Earth's Orbit in the Stars: Parallax and Aberration
During the 17th century the idea of an orbiting and rotating Earth became
increasingly popular, but opponents of this view continued to point out that
the theory had observable consequences that had never, in fact, been observed.
Why, for instance, had astronomers failed to detect the annual parallax of the
stars that must occur if Earth orbits the Sun? To address this problem,
astronomers of the 17th and18th centuries sought to measure the annual parallax
of stars using telescopes. None of them succeeded. Annual stellar parallax was
not successfully measured until 1838, when Friedrich Bessel detected the
parallax of the star 61 Cygni. But the early failures to detect annual stellar
parallax led to the discovery of a new (and entirely unexpected) phenomenon:
the aberration of starlight. This paper recounts the story of the discovery of
stellar aberration. It is accompanied by a set of activities and computer
simulations that allow students to explore this fascinating historical episode
and learn important lessons about the nature of science.Comment: 10 pages, 5 figures, submitted to The Physics Teache
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