Association between urinary sodium, creatinine, albumin, and long term survival in chronic kidney disease

Dietary sodium intake is associated with hypertension and cardiovascular risk in the general population. In patients with chronic kidney disease, sodium intake has been associated with progressive renal disease, but not independently of proteinuria. We studied the relationship between urinary sodium excretion and urinary sodium:creatinine ratio and mortality or requirement for renal replacement therapy in chronic kidney disease. Adults attending a renal clinic who had at least one 24-hour urinary sodium measurement were identified. 24-hour urinary sodium measures were collected and urinary sodium:creatinine ratio calculated. Time to renal replacement therapy or death was recorded. 423 patients were identified with mean estimated glomerular filtration rate of 48ml/min/1.73m<sup>2</sup>. 90 patients required renal replacement therapy and 102 patients died. Mean slope decline in estimated glomerular filtration rate was -2.8ml/min/1.73m<sup>2</sup>/year. Median follow-up was 8.5 years. Patients who died or required renal replacement therapy had significantly higher urinary sodium excretion and urinary sodium:creatinine but the association with these parameters and poor outcome was not independent of renal function, age and albuminuria. When stratified by albuminuria, urinary sodium:creatinine was a significant cumulative additional risk for mortality, even in patients with low level albuminuria. There was no association between low urinary sodium and risk, as observed in some studies. This study demonstrates an association between urinary sodium excretion and mortality in chronic kidney disease, with a cumulative relationship between sodium excretion, albuminuria and reduced survival. These data support reducing dietary sodium intake in chronic kidney disease but further study is required to determine the target sodium intake

CONTEST : a Controllable Test Matrix Toolbox for MATLAB

Large, sparse networks that describe complex interactions are a common feature across a number of disciplines, giving rise to many challenging matrix computational tasks. Several random graph models have been proposed that capture key properties of real-life networks. These models provide realistic, parametrized matrices for testing linear system and eigenvalue solvers. CONTEST (CONtrollable TEST matrices) is a random network toolbox for MATLAB that implements nine models. The models produce unweighted directed or undirected graphs; that is, symmetric or unsymmetric matrices with elements equal to zero or one. They have one or more parameters that affect features such as sparsity and characteristic pathlength and all can be of arbitrary dimension. Utility functions are supplied for rewiring, adding extra shortcuts and subsampling in order to create further classes of networks. Other utilities convert the adjacency matrices into real-valued coefficient matrices for naturally arising computational tasks that reduce to sparse linear system and eigenvalue problems

Spectacular Shells in the Host Galaxy of the QSO MC2 1635+119

We present deep HST/ACS images and Keck spectroscopy of MC2 1635+119, a QSO hosted by a galaxy previously classified as an undisturbed elliptical. Our new images reveal dramatic shell structure indicative of a merger event in the relatively recent past. The brightest shells in the central regions of the host are distributed alternately in radius, with at least two distinct shells on one side of the nucleus and three on the other, out to a distance of ~13 kpc. The light within the five shells comprises ~6% of the total galaxy light. Lower surface brightness ripples or tails and other debris extend out to a distance of ~65 kpc. A simple N-body model for a merger reproduces the inner shell structure and gives an estimate for the age of the merger between ~30 Myr and ~1.7 Gyr, depending on a range of reasonable assumptions. While the inner shell structure is suggestive of a minor merger, the total light contribution from the shells and extended structures are more indicative of a major merger. The spectrum of the host galaxy is dominated by a population of intermediate age (~1.4 Gyr), indicating a strong starburst episode that may have occurred at the time of the merger event. We speculate that the current QSO activity may have been triggered in the recent past by either a minor merger, or by debris from an older (~Gyr) major merger that is currently ``raining'' back into the central regions of the merger remnant.Comment: 14 pages, 5 figures. Accepted for publication in the Astrophysical Journa

Trends in Consumer Behavior Literature: A Content Analysis

While a comprehensive review and classification of consumer behavior literature has been called for periodically, none has been forthcoming. This paper attempts partially to rectify this situation. It classifies by several key variables 32 years of consumer behavior literature from selected journals and proceedings

The Dormancy Dilemma: Quiescence versus Balanced Proliferation

Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of morbidity and mortality from most solid tumors. Even more daunting is that many of these metastatic deposits silently lie undetected, recurring years to decades after primary tumor extirpation by surgery or radiation (termed metastatic dormancy). As primary tumors are frequently curable, a critical focus now turns to preventing the lethal emergence from metastatic dormancy. Current carcinoma treatments include adjuvant therapy intended to kill the cryptic metastatic tumor cells. Because such standard therapies mainly kill cycling cells, this approach carries an implicit assumption that metastatic cells are in the mitogenic cycle. Thus, the pivotal question arises as to whether clinically occult micrometastases survive in a state of balanced proliferation and death, or whether these cells undergo at least long periods of quiescence marked by cell-cycle arrest. The treatment implications are thus obvious—if the carcinoma cells are cycling then therapies should target cycling cells, whereas if cells are quiescent then therapies should either maintain dormancy or be toxic to dormant cells. Because this distinction is paramount to rational therapeutic development and administration, we investigated whether quiescence or balanced proliferation is the most likely etiology underlying metastatic dormancy. We recently published a computer simulation study that determined that balanced proliferation is not the likely driving force and that quiescence most likely participates in metastatic dormancy. As such, a greater emphasis on developing diagnostics and therapeutics for quiescent carcinomas is needed.National Institutes of Health (U.S.). National Center for Advancing Translational Sciences (Grant UH2TR000496

Effect of left atrial and ventricular abnormalities on renal transplant recipient outcome—a single-center study

Background: Premature cardiovascular (CV) death is the commonest cause of death in renal transplant recipients. Abnormalities of left ventricular (LV) structure (collectively termed uremic cardiomyopathy) and left atrial (LA) dilation, a marker of fluid status and diastolic function, are risk factors for reduced survival in patients with end stage renal disease (ESRD). In the present analysis, we studied the impact of pre-transplant LA and LV abnormalities on survival after successful renal transplantation (RT).<p></p> Methods: One hundred nineteen renal transplant recipients (first transplant, deceased donors) underwent cardiovascular MRI (CMR) as part of CV screening prior to inclusion on the waiting list. Data regarding transplant function and patient survival after transplantation were collected.<p></p> Results: Median post-transplant follow-up was 4.3 years (interquartile range (IQR) 1.9, 6.2). During the post-transplant period, 13 patients returned to dialysis after graft failure and 23 patients died with a functioning graft. Survival analyses, censoring for patients returning to dialysis, showed that pre-transplant LV hypertrophy and elevated LA volume were significantly associated with reduced survival after transplantation. Multivariate Cox regression analyses demonstrated that longer waiting time, poorer transplant function, presence of LV hypertrophy and higher LA volume on screening CMR and female sex were independent predictors of death in patients with a functioning transplant.<p></p> Conclusions: Presence of LVH and higher LA volume are significant, independent predictors of death in patients who are wait-listed and proceed with renal transplantation.<p></p> METHODS: One hundred nineteen renal transplant recipients (first transplant, deceased donors) underwent cardiovascular MRI (CMR) as part of CV screening prior to inclusion on the waiting list. Data regarding transplant function and patient survival after transplantation were collected.<p></p> RESULTS: Median post-transplant follow-up was 4.3 years (interquartile range (IQR) 1.9, 6.2). During the post-transplant period, 13 patients returned to dialysis after graft failure and 23 patients died with a functioning graft. Survival analyses, censoring for patients returning to dialysis, showed that pre-transplant LV hypertrophy and elevated LA volume were significantly associated with reduced survival after transplantation. Multivariate Cox regression analyses demonstrated that longer waiting time, poorer transplant function, presence of LV hypertrophy and higher LA volume on screening CMR and female sex were independent predictors of death in patients with a functioning transplant.<p></p> CONCLUSIONS: Presence of LVH and higher LA volume are significant, independent predictors of death in patients who are wait-listed and proceed with renal transplantation

Agonistic Behaviour and Biogenic Amines in Shore Crabs Carcinus Maenas

To investigate the role of certain neurohormones in agonistic behaviour, fights were staged between pairs of size-matched male shore crabs Carcinus maenas, and blood samples were taken immediately after the contests had been resolved. Samples were also taken from these crabs at rest (before and after fighting) and after walking on a treadmill. A control group of crabs also had samples taken on each experimental day. Concentrations of tyramine, dopamine, octopamine, serotonin (5-HT) and norepinephrine were determined in each blood sample using a gas chromatography/mass spectrometry (GC-MS) system. Norepinephrine was not detectable in any of the samples, but the standards were recovered. Tyramine values were not significantly different between the control group and the fought group, so tyramine does not appear to be important in agonistic behaviour. A comparison between the control and fought groups shows that fighting had an effect on the concentrations of octopamine, dopamine and 5-HT, but exercise only had an effect on octopamine levels, which showed a reduction from resting values in both winners and losers. Resting and post-fight concentrations of octopamine, dopamine and 5-HT were higher in winners than in losers. 5-HT concentration increased in the blood of fought crabs from resting values, whereas dopamine concentration decreased. In winners, octopamine concentrations decreased from resting values, but in losers octopamine levels increased from resting concentrations. The escalatory behaviour or intensity of fighting performed by winners and losers was related to dopamine levels but not to those of octopamine or 5-HT. Therefore, there appears to be a link between relative concentrations of these three amines (dopamine, octopamine and 5-HT) and fighting ability; the effects are not simply a result of activity. The better competitors have higher concentrations of these three amines at rest and after fighting

Near Infrared Adaptive Optics Imaging of QSO Host Galaxies

We report near-infrared (primarily H-band) adaptive optics (AO) imaging with the Gemini-N and Subaru Telescopes, of a representative sample of 32 nearby (z<0.3) QSOs selected from the Palomar-Green (PG) Bright Quasar Survey (BQS), in order to investigate the properties of the host galaxies. 2D modeling and visual inspection of the images shows that ~36% of the hosts are ellipticals, \~39% contain a prominent disk component, and ~25% are of undetermined type. 30% show obvious signs of disturbance. The mean M_H(host) = -24.82 (2.1L_H*), with a range -23.5 to -26.5 (~0.63 to 10 L_H*). At <L_H*, all hosts have a dominant disk component, while at >2 L_H* most are ellipticals. "Disturbed" hosts are found at all M_H(host), while "strongly disturbed" hosts appear to favor the more luminous hosts. Hosts with prominent disks have less luminous QSOs, while the most luminous QSOs are almost exclusively in ellipticals or in mergers (which presumably shortly will be ellipticals). At z<0.13, where our sample is complete at B-band, we find no clear correlation between M_B(QSO) and M_H(host). However, at z>0.15, the more luminous QSOs (M_B<-24.7), and 4/5 of the radio-loud QSOs, have the most luminous H-band hosts (>7L_H*), most of which are ellipticals. Finally, we find a strong correlation between the "infrared-excess", L_IR/L_BB, of QSOs with host type and degree of disturbance. Disturbed and strongly disturbed hosts and hosts with dominant disks have L_IR/L_BB twice that of non-disturbed and elliptical hosts, respectively. QSOs with "disturbed" and "strongly-disturbed" hosts are also found to have morphologies and mid/far-infrared colors that are similar to what is found for "warm" ultraluminous infrared galaxies, providing further evidence for a possible evolutionary connection between both classes of objects.Comment: 80 pages, accepted for publication in ApJ Supp

Reorganize your blogs: Supporting blog re-visitation with natural language processing and visualization

Temporally-connected personal blogs contain voluminous textual content, presenting challenges in re-visiting and reflecting on experiences. Other data repositories have benefited from natural language processing (NLP) and interactive visualizations (VIS) to support exploration, but little is known about how these techniques could be used with blogs to present experiences and support multimodal interaction with blogs, particularly for authors. This paper presents the effect of reorganization—reorganizing the large blog set with NLP and presenting abstract topics with VIS—to support novel re-visitation experiences to blogs. The BlogCloud tool, a blog re-visitation tool that reorganizes blog paragraphs around user-searched keywords, implements reorganization and similarity-based content grouping. Through a public use session with bloggers who wrote about extended hikes, we observed the effect of NLP-based reorganization in delivering novel re-visitation experiences. Findings suggest that the re-presented topics provide new reflection materials and re-visitation paths, enabling interaction with symbolic items in memory

<i>N,N</i>-bis-(dimethylfluorosilylmethyl)amides of <i>N</i>-organosulfonylproline and sarcosine: synthesis, structure, stereodynamic behaviour and <i>in silico</i> studies

(O→Si)-Chelate difluorides R3R2NCH(R1)C(O)N(CH2SiMe2F)2 (9a–c, R1R2 = (CH2)3, R3 = Ms (a), Ts (b); R1 = H, R2 = Me, R3 = Ms (c)), containing one penta- and one tetracoordinate silicon atoms were synthesized by silylmethylation of amides R3R2NCH(R1)C(O)NH2, subsequent hydrolysis of unstable intermediates R3R2NCH(R1)C(O)N(CH2SiMe2Cl)2 (7a–c) into 4-acyl-2,6-disilamorpholines R3R2NCH(R1)C(O)N(CH2SiMe2O)2 (8a–c) and the reaction of the latter compounds with BF3·Et2O. The structures of disilamorpholines 8a,c and difluoride 9a were confirmed by an X-ray diffraction study. According to the IR and NMR data, the O→Si coordination in solutions of these compounds was weaker than that in the solid state due to effective solvation of the Si–F bond. A permutational isomerisation involving an exchange of equatorial Me groups at the pentacoordinate Si atom in complexes 9a–c was detected, and its activational parameters were determined by 1H DNMR. In silico estimation of possible pharmacological effects and acute rat toxicity by PASS Online and GUSAR Online services showed a potential for their further pharmacological study