586 research outputs found
Goffman Turns to Me and Says, “Only a Schmuck Studies His Own Life”
This conversation with Gary Alan Fine, John Evans Professor of Sociology at Northwestern University, was recorded over the phone on August 21, 2009. Dmitri Shalin transcribed the interview, after which Dr. Fine edited the transcript and approved posting the present version in the Erving Goffman Archives. Breaks in the conversation flow are indicated by ellipses. Supplementary information and additional materials inserted during the editing process appear in square brackets. Undecipherable words and unclear passages are identified in the text as “[?]”
Of Forfeiture, Facilitation and Foreign Innocent Owners: Is a Bank Account Containing Parallel Market Funds Fair Game?
Based on sworn testimony that 680 bank accounts in the United
States containing nearly $400 million\u27 were the operating accounts
of the Medellin cartel, U.S. District Judge William C. O\u27Kelley issued
an order temporarily restraining them on April 16, 1990
Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus
Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to the established role of muscarinic receptors. In the hippocampus, where cholinergic involvement in learning and memory is particularly well documented, 7 nicotinic acetylcholine receptor subunits (7 nAChRs) are highly expressed, but their precise ultrastructural localization has not been determined. Here, we describe the results of immunogold labeling of serial ultrathin sections through stratum radiatum of area CA1 in the rat. Using both anti-7 nAChR immunolabeling and -bungarotoxin binding, we find that 7 nAChRs are present at nearly all synapses in CA1 stratum radiatum, with immunolabeling present at both presynaptic and postsynaptic elements. Morphological considerations and double immunolabeling indicate that GABAergic as well as glutamatergic synapses bear 7 nAChRs, at densities approaching those observed for glutamate receptors in CA1 stratum radiatum. Postsynaptically, 7 nAChRs often are distributed at dendritic spines in a perisynaptic annulus. In the postsynaptic cytoplasm, immunolabeling is associated with spine apparatus and other membranous structures, suggesting that 7 nAChRs may undergo dynamic regulation, with insertion into the synapse and subsequent internalization. The widespread and substantial expression of 7 nAChRs at synapses in the hippocampus is consistent with an important role in mediating and/or modulating synaptic transmission, plasticity, and neurodegeneration
Tiny Publics and Social Worlds—Toward a Sociology of the Local. Gary Alan Fine in Conversation With Reiner Keller
Gary Alan FINE gehört weltweit zu den prominentesten Persönlichkeiten der zeitgenössischen soziologischen Ethnografie. In diesem Gespräch spricht er über Einflüsse in seiner akademischen Laufbahn und prägende intellektuelle Entscheidungen. Er gilt als "serieller Ethnograf", der in zahlreichen Feldkontexten gearbeitet hat und dabei einerseits Kleingruppen und eine von Menschen bevölkerte Ethnografie favorisiert, sich andererseits mit Gerüchten, Klatsch und moralischen Geschichten beschäftigt, die in kleinen und größeren Publiken erzählt werden. FINE beschreibt sein theoretisches Kerninteresse als die Untersuchung des Wechselspiels von Struktur, Interaktion und Kultur. In seinem Werk analysiert er die vielfältigen ortsgebundenen Arten und Weisen, in denen Gesellschaft von Menschen in formellen und informellen sozialen Settings verwirklicht wird, angefangen bei Baseballteams über Restaurantküchen oder die Wetterberichterstattung bis hin zum Schachspielen –um nur einige wenige Gegenstände seiner Forschungen zu nennen. Wesentlich beeinflusst durch symbolisch-interaktionistisches Denken und im Rekurs auf weitere wichtige Perspektiven auf soziale Welten plädiert er für eine selbstbewusste Haltung der ethnografischen Forschung und des ethnografischen Schreibens sowie für die Bedeutung der Konzeptarbeit in einer theorie-informierten empirischen Soziologie dessen, was Menschen zusammen tun.Gary Alan FINE is among the most prominent figures in contemporary sociological ethnography worldwide. In this conversation, he talks about influences in his academic career and key intellectual choices. Considered to be a "serial ethnographer" who has worked in multiple settings, his work focuses on small groups and peopled ethnography, as well as on rumors, gossip, and moral story telling in tiny and larger publics. FINE describes his core theoretical interest as residing in the interplay of structure, interaction, and culture and discusses the multiple local ways society is realized by people in formal and informal social settings: ranging from baseball teams, restaurant kitchens, weather reporting to chess players—to name but a few research sites. Influenced by symbolic interactionist thinking and other important approaches to social worlds, he argues for a confident voice of ethnographic research and writing as well as the importance of conceptual work in a theory-informed empirical sociology of what people do together
Single Synaptic Events Evoke NMDA Receptor–Mediated Release of Calcium from Internal Stores in Hippocampal Dendritic Spines
AbstractWe have used confocal microscopy to monitor synaptically evoked Ca2+ transients in the dendritic spines of hippocampal pyramidal cells. Individual spines respond to single afferent stimuli (<0.1 Hz) with Ca2+ transients or failures, reflecting the probability of transmitter release at the activated synapse. Both AMPA and NMDA glutamate receptor antagonists block the synaptically evoked Ca2+ transients; the block by AMPA antagonists is relieved by low Mg2+. The Ca2+ transients are mainly due to the release of calcium from internal stores, since they are abolished by antagonists of calcium-induced calcium release (CICR); CICR antagonists, however, do not depress spine Ca2+ transients generated by backpropagating action potentials. These results have implications for synaptic plasticity, since they show that synaptic stimulation can activate NMDA receptors, evoking substantial Ca2+ release from the internal stores in spines without inducing long-term potentiation (LTP) or depression (LTD)
- …