Genetic, cellular and molecular mechanisms of pulmonary arterial hypertension

WOS: 000282728600004PubMed ID: 20819762Pulmonary arterial hypertension (PAH) is an uncommon disorder that may be hereditable, idiopathic or associated with conditions like drug exposure, connective tissue disease, HIV infection or congenital heart disease. Familial disease are usually due to mutations in the bone morphogenic protein receptor type 2 (BMPR2), activin-like kinase-type 1 (ALK1) and endoglin (ENG). Functional and structural changes in the pulmonary vasculature lead to increased pulmonary vascular resistance. Vascular remodeling involves endothelial dysfunction, activation of fibroblasts and smooth muscle cells and recruitment of circulating progenitor cells. Vasoconstriction has also been shown to affect the remodeling process. Genetics, cellular and molecular basis of PAH are discussed in the paper. (Anadolu Kardiyol Derg 2010; 10: Suppl 1; 9-13

Lipid profile, familial hypercholesterolemia prevalence, and 2-year cardiovascular outcome assessment in acute coronary syndrome: Real-life data of a retrospective cohort

WOS: 000484379600008PubMed ID: 31483296Objective: The aim of this retrospective study based on real-life data was to evaluate the lipid profile and demographic, clinical, and laboratory features of patients with acute coronary syndrome (ACS) at a tertiary center and to examine the mortality rate. Methods: Information including endpoint data for at least 2 years following the index ACS event was retrieved from hospital records. Patients without sufficient follow-up data were called by phone. Modified Dutch Lipid Clinic Network criteria were used to identify the presence of familial hypercholesterolemia (FH). Factors affecting mortality in the 2-year follow-up period were evaluated using Cox regression analysis. Results: A total of 985 ACS patients (215 females) between 21 and 93 years of age were included. The females were older and had a lower smoking rate than the males. In females, the history of obesity and hypertension, the diabetes rate, and the thyroid-stimulating hormone level were higher than those of the males. In 95.6% of the patients, lipid parameters were measured upon hospital admission. No significant difference in dyslipidemia frequency was observed between genders. The frequency of FH was 7.6%. The rate of lipid-lowering drug use was 90% at discharge, and decreased to 50% in the follow-up period. The mortality rate was 3.8% in the in-hospital period and 8.1% during the 2 years of follow-up. Conclusion: The mortality rate in ACS patients was 3.8% in the in-hospital period and 8.1% in the 2-year follow-up period. The frequency of hypercholesterolemia was 89.5% and the rate of lipid-lowering drug use was insufficient. Secondary prevention after ACS was not adequately employed even at a tertiary center. The FH frequency was 7.6% and those with FH were observed to have ACS at a younger age than those without

Belirteçler

Kitabın telif hakları Gazi Kitabevine aittir.Belirteçler, Türk dilbilgisinin anlama dayalı çok önemli bir sınıfıdır. Belirteçler, dilbilgisinde adlar dışında kalan bütün dilbilgisi birliklerini çeşitli yönlerden açıklıyor olmasından dolayı önemlidir. Dilbilgisi kitaplarında belirteçlerin tanımı dar yapılmıştır. Bu tanım daha geniş bir şekilde yapılabilir. Belirteçler sıfatları, diğer belirteçleri, eylemleri, eylemsileri ve tümcenin tamamını açıklayabilir. Türkçede gerçek anlamda belirteç ekleri bulunmaz. Belirteçler, çok çeşitli dilbilgisi yapıları içinde çok geniş anlam ve işlev özellikleri kazanırlar. Bu sebeple çekim ekleri (ile > -la ekleşmiş ilgeç), sıfatlar, eylemsiler ve yardımcı tümceler, belirteç işlevini alabilirler.Gazi Kitabev

Gender-related clinical and management differences in patients with chronic heart failure with reduced ejection fraction

Aim Gender-related differences have been described in the clinical characteristics and management of patients with chronic heart failure with reduced ejection fraction (HFrEF). However, published data are conflictive in this regard

Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults

Background: The fatality attributed to pandemic influenza A H1N1 was not clear in the literature. We described the predictors for fatality related to pandemic influenza A H1N1 infection among hospitalized adult patients

Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults

Background: The fatality attributed to pandemic influenza A H1N1 was not clear in the literature. We described the predictors for fatality related to pandemic influenza A H1N1 infection among hospitalized adult patients