Drivers, enablers and barriers of developing commercialisation in an oil-dependent economy: the case of Saudi Arabia

Faced with depleted oil stocks from 2035 onwards, the Kingdom of Saudi Arabia has a strategy of becoming a more knowledge-based economy by indigenously exploiting transferred technologies. However, despite significant investment in university-based technology transfer and incubation facilities, there is little progress in establishing high-growth advanced technology companies outside of the oil sector. The thesis explores the commercialisation of university knowledge in university-based incubators in the Kingdom of Saudi Arabia and contrasting with arrangements in the UK, to identify the cause of low spinout rates and what can be done. Beginning with a systematic review of literature on innovation and entrepreneurship as it applies to commercialisation, the thesis identifies gaps and areas of controversy in the literature. From previous research an initial conceptual framework is developed to guide data gathering, its presentation and analysis. Using a qualitative method a sample of twenty-four Saudi interviews and eight UK interviews is justified. Significant new data on Saudi incubator policy, processes and outcomes is presented alongside new data from the UK. This is then analysed from an in-case and cross-case perspective and then re-integrated with literature. A revised conceptual framework is presented and conclusions for theory and practice drawn. The thesis adds to the multidisciplinary bodies of knowledge for example by updating Gerschenkron’s (1966) theory of catch-up, challenging the validity of Etzkowitz’s (1983) triple helix theory, and arguing that North’s (1990) neo-institutional theory is ethnocentric. I argue that culture is a major influence on commercialisation in developing countries and consciously changing cultures necessary for Saudi Arabia’s transition from a rentier state. I find little empirical evidence in either the UK or Saudi Arabia for theories (Shane 2004) of academic entrepreneurship. I conclude that major reforms of Saudi universities and commercialisation processes are necessary if the strategy is to contribute significantly towards diversification of the economy

A cross-sectional study on the flood emergency preparedness among healthcare providers in Saudi Arabia

This study used a descriptive cross-sectional methodology to measure healthcare workers’ knowledge, attitudes, perceptions, and willingness to respond to a flood scenario in Saudi Arabia. A validated survey was distributed to collect data using a convenience sampling technique through multiple social media platforms. A total of 227 participants were included in this study: 52% of them were aged between 26 to 34 years, 74% were residents from Riyadh, and 52.4% worked in nursing divisions. A significant number of respondents (73.2%) had positive perceptions towards their hospitals’ ability to provide an effective response to a flood, 89% were willing to report to work following a flood, and 90% of participants reported the need to develop both guidelines and training for flood disaster preparedness. Preparation and successful flood mitigation in the hospital setting requires staff that have both knowledge and training in emergency management. One way to obtain such readiness is through competency-based training, including both table-top and full-scale live exercises. Although the willingness to respond to such a flooding emergency was high among staff, the development of guidelines and educational programs is needed in order to develop the competencies and skills sets to improve disaster preparedness response and preparedness efforts

Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions

Most monogenic disorders have a primary clinical presentation. Inherited ISG15 deficiency, however, has manifested with two distinct presentations to date: susceptibility to mycobacterial disease and intracranial calcifications from hypomorphic interferon-II (IFN-II) production and excessive IFN-I response, respectively. Accordingly, these patients were managed for their infectious and neurologic complications. Herein, we describe five new patients with six novel ISG15 mutations presenting with skin lesions who were managed for dermatologic disease. Cellularly, we denote striking specificity to the IFN-I response, which was previously assumed to be universal. In peripheral blood, myeloid cells display the most robust IFN-I signatures. In the affected skin, IFN-I signaling is observed in the keratinocytes of the epidermis, endothelia, and the monocytes and macrophages of the dermis. These findings define the specific cells causing circulating and dermatologic inflammation and expand the clinical spectrum of ISG15 deficiency to dermatologic presentations as a third phenotype co-dominant to the infectious and neurologic manifestations.Fil: Martin Fernandez, Marta. Icahn School Of Medicine At Mount Sinai; Estados Unidos. King Saud University; Arabia SauditaFil: Bravo García Morato, María. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Gruber, Conor. Icahn School Of Medicine At Mount Sinai; Estados Unidos. King Saud University; Arabia SauditaFil: Murias Loza, Sara. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Malik, Muhammad Nasir Hayat. Twincore; Alemania. University Of Lahore; Países Bajos. Leibniz Universitat Hannover; Alemania. Helmholtz Gemeinschaft; AlemaniaFil: Alsohime, Fahad. King Saud University; Arabia SauditaFil: Alakeel, Abdullah. King Saud University; Arabia SauditaFil: Valdez, Rita. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; ArgentinaFil: Buta, Sofija. Icahn School Of Medicine At Mount Sinai; Estados UnidosFil: Buda, Guadalupe. Bitgenia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Biología Celular e Histología; ArgentinaFil: Marti, Marcelo Adrian. Bitgenia; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Biología Celular e Histología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Larralde, Margarita. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Boisson, Bertrand. L'institut Des Maladies Génétiques Imagine; Francia. The Rockefeller University; Estados Unidos. Universite de Paris; FranciaFil: Feito Rodriguez, Marta. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Qiu, Xueer. Icahn School Of Medicine At Mount Sinai; Estados UnidosFil: Chrabieh, Maya. L'institut Des Maladies Génétiques Imagine; FranciaFil: Al Ayed, Mohammed. Najran University; Arabia SauditaFil: Al Muhsen, Saleh. King Saud University; Arabia SauditaFil: Desai, Jigar V.. National Institutes of Health; Estados UnidosFil: Ferre, Elise M.N.. National Institutes of Health; Estados UnidosFil: Rosenzweig, Sergio D.. National Institutes of Health; Estados UnidosFil: Amador-Borrero, Blanca. Icahn School Of Medicine At Mount Sinai; Estados UnidosFil: Bravo-Gallego, Luz Yadira. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Olmer, Ruth. Hannover Medical School; Alemania. German Center for Lung Research; AlemaniaFil: Merkert, Sylvia. Hannover Medical School; Alemania. German Center for Lung Research; AlemaniaFil: Bret, Montserrat. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Sood, Amika K.. University of North Carolina; Estados UnidosFil: Al-rabiaah, Abdulkarim. King Saud University; Arabia SauditaFil: Temsah, Mohamad Hani. King Saud University; Arabia SauditaFil: Halwani, Rabih. University of Sharjah; Emiratos Arabes UnidosFil: Hernandez, Michelle Marilyn. University of North Carolina; Estados UnidosFil: Pessler, Frank. Twincore; Alemania. Helmholtz Centre for Infection Research; AlemaniaFil: Casanova, Jean Laurent. The Rockefeller University; Estados Unidos. Necker Hospital for Sick Children; Francia. Howard Hughes Medical Institute; Estados Unidos. Universite de Paris; FranciaFil: Bustamante, Jacinta. The Rockefeller University; Estados Unidos. Necker Hospital for Sick Children; Francia. Universite de Paris; FranciaFil: Lionakis, Michail S.. National Institutes of Health; Estados UnidosFil: Bogunovic, Dusan. Icahn School Of Medicine At Mount Sinai; Estados Unido

Measuring the health literacy level of Arabic speaking population in Saudi Arabia using translated health literacy instruments

Background: Health literacy is an essential predictor of health status, disease control and adherence to medications. Objectives: The study goals were to assess the health literacy level of the general population in Saudi Arabia using translated Gulf Arabic version of the short-version of the Test of Functional Health Literacy in Adults (S-TOFHLA) and Single Item Literacy Screener (SILS) tests and to measure the relationship between health literacy and education level. Methods: The study was a cross-sectional with a convenience sample of 123 participants from the general population in Riyadh. Data were collected using the modified (Gulf) Arabic versions of both S-TOFHLA and SILS. Fisher’s Exact test was used to measure the difference of the health literacy scores according to the education degrees and Cronbach’s alpha was used to measure the internal consistency of the S-TOFHLA items. Results: More than half (55.4%) of the participants were male, 50.4% had a middle school or less education level, and we found that 84.4% had adequate health literacy as measured by the S-TOFHLA, compared to 49.6% as measured by SILS. The Fisher’s Exact test showed a significant difference (P<.05) in the S-TOFHLA and SILS scores according to education categories. Conclusions: The level of education has a significant positive association with S-TOFHLA and SILS results. The Gulf Arabic version of S-TOFHLA is a reliable test with a good internal consistency and a significant positive correlation between the two parts of S-TOFHLA. We recommend the use of S-TOFHLA or SILS at the first patient visit.

PUBLIC AWARENESS TOWARDS HEPATITIS B AMONG GENERAL POPULATION, IN SAUDI ARABIA

Background: Hepatitis Virus B is a major health problem worldwide as well as in Kingdom of Saudi Arabia (KSA) as it is one of the most common contagious infection and cost effective. Objectives: To Evaluate the knowledge, attitude and practice (KAP) of general population toward hepatitis B infection in KSA. Methods: A cross-sectional study was conducted among 500 Saudi participants aged between 20-60 years old. Participants were conducted during the period from December 2018 till January 2019 and the questionnaire was consisted of 4 parts including the demographics information and KAP. Results: 500 participants have filled the surveys. The age of the participants were from 20-60 years/old and the majority were between 20- and 30 years old (33.8%). Regarding the knowledge, (87%) have heard about hepatitis disease and (81%) know that hepatitis B affects the liver. Regarding the attitude, (82.8%) will visit physician if they get hepatitis. But unfortunately, only (56%) have been vaccinated against hepatitis B. Conclusion: The level of KAP toward hepatitis B was moderately acceptable in most of our sample but with insufficient practice among most of participants. More campaigns should be conducted increase the level of awareness towards the disease. Keywords: KAP, Hepatitis B, Saudi Arabia

Long-Term Impact of Transhumance Pastoralism and Associated Disturbances in High-Altitude Forests of Indian Western Himalaya

The Himalayan Mountains are geodynamical important, featuring a wide climatic range with a rich diversity of flora, fauna, human communities, culture, and social set-up. In recent decades, due to constant anthropogenic pressure and considerable changes witnessed in the climate of the region, species of this region are threatened. Here, we assessed the impact of nomadic settlement and associated disturbances on plant species composition, diversity parameters, ecosystem properties, and fire incidence in high-altitude forests of Western Himalaya, India. Based on the distance between nomadic settlement location and forest, we classified forest as near nomadic settlement (NNS) or away nomadic settlement (ANS) forest types. We found a significant variation in plant species composition between forest types. Three species, namely, Sibbaldia cuneata, Poa annua, and Abies pindrow, contribute 25% of the cumulative variation in plant species composition. Studying live plants, we found a significant difference only for density, in which ANS had a higher average density than NNS. Considering dead plants, we found a significant difference in all nine plant-related parameters evaluated between sites. NNS had a higher value of all parameters evaluated, except for height, which was higher in ANS sites. ANS forest type show 1.3 times more average carbon stock (160.39 ± 59.03 MgCha−1; mean ± SD) than NNS forest type (120.40 ± 51.74 MgCha−1). We found a significant difference in plant diversity evaluated between forest types. ANS had higher values of Margalef and Fisher diversity but lower values of evenness. We found that NSS had significantly higher values of fire incidences, whereas ANS has a higher normalized differential vegetation index and enhanced vegetation index. Overall, our study showed that species composition, diversity, and fire incidence are strongly impacted due to nomadic settlements. These findings are paramount for designing appropriate livelihood options for indigenous communities and management policies of the long-term forest harvest to achieve global goals and the UN Decade on Ecosystem Restoration targets (2021–2030) to protect the sustainable development of forest mountainous regions

Long-Term Impact of Transhumance Pastoralism and Associated Disturbances in High-Altitude Forests of Indian Western Himalaya

The Himalayan Mountains are geodynamical important, featuring a wide climatic range with a rich diversity of flora, fauna, human communities, culture, and social set-up. In recent decades, due to constant anthropogenic pressure and considerable changes witnessed in the climate of the region, species of this region are threatened. Here, we assessed the impact of nomadic settlement and associated disturbances on plant species composition, diversity parameters, ecosystem properties, and fire incidence in high-altitude forests of Western Himalaya, India. Based on the distance between nomadic settlement location and forest, we classified forest as near nomadic settlement (NNS) or away nomadic settlement (ANS) forest types. We found a significant variation in plant species composition between forest types. Three species, namely, Sibbaldia cuneata, Poa annua, and Abies pindrow, contribute 25% of the cumulative variation in plant species composition. Studying live plants, we found a significant difference only for density, in which ANS had a higher average density than NNS. Considering dead plants, we found a significant difference in all nine plant-related parameters evaluated between sites. NNS had a higher value of all parameters evaluated, except for height, which was higher in ANS sites. ANS forest type show 1.3 times more average carbon stock (160.39 ± 59.03 MgCha−1; mean ± SD) than NNS forest type (120.40 ± 51.74 MgCha−1). We found a significant difference in plant diversity evaluated between forest types. ANS had higher values of Margalef and Fisher diversity but lower values of evenness. We found that NSS had significantly higher values of fire incidences, whereas ANS has a higher normalized differential vegetation index and enhanced vegetation index. Overall, our study showed that species composition, diversity, and fire incidence are strongly impacted due to nomadic settlements. These findings are paramount for designing appropriate livelihood options for indigenous communities and management policies of the long-term forest harvest to achieve global goals and the UN Decade on Ecosystem Restoration targets (2021–2030) to protect the sustainable development of forest mountainous regions

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population