Nothing at Stake in Knowledge

In the remainder of this article, we will disarm an important motivation for epistemic contextualism and interest-relative invariantism. We will accomplish this by presenting a stringent test of whether there is a stakes effect on ordinary knowledge ascription. Having shown that, even on a stringent way of testing, stakes fail to impact ordinary knowledge ascription, we will conclude that we should take another look at classical invariantism. Here is how we will proceed. Section 1 lays out some limitations of previous research on stakes. Section 2 presents our study and concludes that there is little evidence for a substantial stakes effect. Section 3 responds to objections. The conclusion clears the way for classical invariantism

The Gettier Intuition from South America to Asia

This article examines whether people share the Gettier intuition (viz. that someone who has a true justified belief that p may nonetheless fail to know that p) in 24 sites, located in 23 countries (counting Hong Kong as a distinct country) and across 17 languages. We also consider the possible influence of gender and personality on this intuition with a very large sample size. Finally, we examine whether the Gettier intuition varies across people as a function of their disposition to engage in “reflective” thinking

Modeling acid-gas generation from boiling chloride brines

<p>Abstract</p> <p>Background</p> <p>This study investigates the generation of HCl and other acid gases from boiling calcium chloride dominated waters at atmospheric pressure, primarily using numerical modeling. The main focus of this investigation relates to the long-term geologic disposal of nuclear waste at Yucca Mountain, Nevada, where pore waters around waste-emplacement tunnels are expected to undergo boiling and evaporative concentration as a result of the heat released by spent nuclear fuel. Processes that are modeled include boiling of highly concentrated solutions, gas transport, and gas condensation accompanied by the dissociation of acid gases, causing low-pH condensate.</p> <p>Results</p> <p>Simple calculations are first carried out to evaluate condensate pH as a function of HCl gas fugacity and condensed water fraction for a vapor equilibrated with saturated calcium chloride brine at 50-150°C and 1 bar. The distillation of a calcium-chloride-dominated brine is then simulated with a reactive transport model using a brine composition representative of partially evaporated calcium-rich pore waters at Yucca Mountain. Results show a significant increase in boiling temperature from evaporative concentration, as well as low pH in condensates, particularly for dynamic systems where partial condensation takes place, which result in enrichment of HCl in condensates. These results are in qualitative agreement with experimental data from other studies.</p> <p>Conclusion</p> <p>The combination of reactive transport with multicomponent brine chemistry to study evaporation, boiling, and the potential for acid gas generation at the proposed Yucca Mountain repository is seen as an improvement relative to previously applied simpler batch evaporation models. This approach allows the evaluation of thermal, hydrological, and chemical (THC) processes in a coupled manner, and modeling of settings much more relevant to actual field conditions than the distillation experiment considered. The actual and modeled distillation experiments do not represent expected conditions in an emplacement drift, but nevertheless illustrate the potential for acid-gas generation at moderate temperatures (<150°C).</p

Serving the same interests: The Wood Green ricin plot, media–state–terror relations and the ‘terrorism’ dispositif

This article analyses the representations of terrorism that arise out of the BBC’s coverage of the Wood Green ricin plot (2003), the first instance of al-Qaeda-related activity in the United Kingdom during the “war on terror”. Inspired by the work Michel Foucault, the article suggests that the BBC’s representations form part of an emergent “terrorism” dispositif, or apparatus, which draws together seemingly disparate and antagonistic groups into a strategic, mutually-sustaining alliance. The analysis focuses on two weeks’ worth of BBC “News at Ten” bulletins, alongside speeches and press releases issued by the Prime Minister and statements released by al-Qaeda’s leadership. In particular, the article suggests that the BBC’s representations inadvertently work to the advantage of elements within al-Qaeda and the British executive due to the fact that they portray the Wood Green events in ways that are tactically useful to both groups. As such, the article not only provides substantive new empirical insights into the way representations of terrorism were mobilised in the build up to the 2003 invasion of Iraq, but also shows how Foucauldian concepts can provide creative and innovative analytical tools for understanding the dynamics of the contemporary media-state-terrorism relationship

X ray screening identifies active site and allosteric inhibitors of SARS CoV 2 main protease

The coronavirus disease COVID 19 caused by SARS CoV 2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the disease. In a search for a drug against COVID 19, we have performed a high throughput x ray crystallographic screen of two repurposing drug libraries against the SARS CoV 2 main protease Mpro , which is essential for viral replication. In contrast to commonly applied x ray fragment screening experiments with molecules of low complexity, our screen tested already approved drugs and drugs in clinical trials. From the three dimensional protein structures, we identified 37 compounds that bind to Mpro. In subsequent cell based viral reduction assays, one peptidomimetic and six nonpeptidic compounds showed antiviral activity at nontoxic concentrations. We identified two allosteric binding sites representing attractive targets for drug development against SARS CoV

How citizen scientists are rapidly generating big distribution data: lessons from the Arewa Atlas Team, Nigerian Bird Atlas Project

The Arewa Atlas Team (AAT) in northern Nigeria has set an example for a robust methodological data collection and made a big impact for the African Bird Atlas Project. To broaden national bird atlas projects and coverage across the continent, this paper reports on the activities and protocols of the AAT. We set out how we have galvanised bird clubs and bird club members to participate in this important monitoring project. We then focus on a bird atlas expedition conducted to the Bauchi State as an example. The outing was carried out from 24 to 28 September 2020 in line with the BirdMap protocol. For the first time, the AAT atlased 100 pentads and recorded 8 591 individual birds of 222 species (24.21% of Nigerian birds) from 67 families. We explore what can be done with these data, by presenting a summary of descriptions of the birds observed. For instance, we recorded 184 resident species, nine intra-African and 24 Palearctic migrants. The highest bird abundance (120 individuals) was recorded at 11°00′26.9″ N, 9°29′46.5″ E, pentad 1105C0925. Furthermore, the Rock Firefinch Lagonosticta sanguinodorsalis was out-of-range from Lumba. The Tawny Eagle Aquila rapax (Vulnerable) and Pallid Harrier Circus macrourus (Near Threatened) were species of conservation concern. Results of this survey shows that citizen science is a powerful tool to make rapid biodiversity assessments of bird species richness and abundance and provides insights into bird occurrence and composition. This can be extended to distribution over time at a local geographic scale. Continuous efforts to map bird distributions are therefore recommended, mostly in regions and countries where atlas projects have not been established or still in the formative stages. It is important that bird atlas teams maximise ways to accomplish more noteworthy coverage in their respective national bird atlas projects and here we outline how we accomplished this as motivation and a model for the African Bird Atlas Project. Keywords: African bird atlas project; Bauchi State; bird distribution; bird conservation; volunteers; public awarenes