202 research outputs found
Comparison of the effect of liquid humic fertilizers on yield of maize genotypes in Ardabil region
In order to investigate the response of maize genotypes against the application of two types of liquid humic fertilizers (derived from peat and leonardite), an experiment was conducted as factorial based on completely randomized block design with three replications. The main factor was included three conditions (application of peat based and leonardite based humic fertilizer, without the application of humic fertilizer) whereas the sub-factor included six maize genotypes. Results indicate that there was a significant difference between experimental conditions in terms of grain yield at 1% and biological yield at 5% probability levels. Results from mean comparison indicate that ZP677 had the highest (20.89 ton/ha) biological yield, whereas OS 499 had the lowest (16.93 ton/ha). Application of leonardite based liquid humic fertilizer proved to be more productive than the two other conditions. This humic fertilizer produced the highest values for biological yield (21.99 ton/ha) and grain yield (7.09 ton/ha).Key words: Maize, humic, fertilizer, yield
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Acetylation of C-terminal lysines modulates protein turnover and stability of Connexin-32
Background
The gap junction protein, Connexin32 (Cx32), is expressed in various tissues including liver, exocrine pancreas, gastrointestinal epithelium, and the glia of the central and peripheral nervous system. Gap junction-mediated cell-cell communication and channel-independent processes of Cx32 contribute to the regulation of physiological and cellular activities such as glial differentiation, survival, and proliferation; maintenance of the hepatic epithelium; and axonal myelination. Mutations in Cx32 cause X-linked Charcot–Marie–Tooth disease (CMT1X), an inherited peripheral neuropathy. Several CMT1X causing mutations are found in the cytoplasmic domains of Cx32, a region implicated in the regulation of gap junction assembly, turnover and function. Here we investigate the roles of acetylation and ubiquitination in the C-terminus on Cx32 protein function. Cx32 protein turnover, ubiquitination, and response to deacetylase inhibitors were determined for wild-type and C-terminus lysine mutants using transiently transfected Neuro2A (N2a) cells.
Results
We report here that Cx32 is acetylated in transfected N2a cells and that inhibition of the histone deacetylase, HDAC6, results in an accumulation of Cx32. We identified five lysine acetylation targets in the C-terminus. Mutational analysis demonstrates that these lysines are involved in the regulation of Cx32 ubiquitination and turnover. While these lysines are not required for functional Cx32 mediated cell-cell communication, BrdU incorporation studies demonstrate that their relative acetylation state plays a channel-independent role in Cx32-mediated control of cell proliferation.
Conclusion
Taken together these results highlight the role of post translational modifications and lysines in the C-terminal tail of Cx32 in the fine-tuning of Cx32 protein stability and channel-independent functions
Are there neurological symptoms in type 1 of gaucher disease?
Objective Gaucher disease (GD) is a rare inborn error of metabolism, classified as a lipid storage disorders. This disease is caused by a deficiency in glucocerebrosidase enzyme. It has been classified according to the presence or absence of neurological symptoms into the following types: type 1 non-neuropathic, type 2 acute infantile neuropathic and type 3 or chronic neuropathic. We evaluated neurological symptoms in patients with GD1 and GD3 and compared both of these groups. Materials & Methods Eleven patients were identified according to their clinical presentation and the presence of disease confirmed by genetic testing, from 2006-2016, at the Mofid Children Hospital Clinic, Tehran, Iran. We included eight patients with GD 1 and three patients with GD3. Careful neurological examination was performed on these patients during treatment by pediatric neurologist. Results Patients with GD1 had some neurological symptoms including cognitive impairment, developmental disability, behavioral disorder, microcephaly and increased deep tendon reflexes (DTR). Of course, neurological signs in patients with type 3 of GD were different and were included seizures, supranuclear gaze palsy, cerebellar signs, and ataxia. Conclusion The current nomenclature for 3 types of Gaucher disease does not meet all clinical symptoms. Patients with GD1 display many neurological deficits in young ages not reported adequately earlier. © 2018, Iranian Child Neurology Society. All rights reserved
Substitutional doping of Cu in diamond: Mott physics with orbitals
Discovery of superconductivity in the impurity band formed by heavy doping of
boron into diamond (C:B) as well as doping of boron into silicon (Si:B) has
provided a rout for the possibility of new families of superconducting
materials. Motivated by the special role played by copper atoms in high
temperature superconducting materials where essentially Cu orbitals are
responsible for a variety of correlation induced phases, in this paper we
investigate the effect of substitutional doping of Cu into diamond. Our
extensive first principle calculations averaged over various geometries based
on density functional theory, indicates the formation of a mid-gap band, which
mainly arises from the and states of Cu. For impurity
concentrations of more than 2pt_{2g}4p\sim 5%, completely closes the
spectral gap of the host diamond.Comment: 5 figure
Devil's staircase transition of the electronic structures in CeSb
Solids with competing interactions often undergo complex phase transitions
with a variety of long-periodic modulations. Among such transition, devil's
staircase is the most complex phenomenon, and for it, CeSb is the most famous
material, where a number of the distinct phases with long-periodic
magnetostructures sequentially appear below the Neel temperature. An evolution
of the low-energy electronic structure going through the devil's staircase is
of special interest, which has, however, been elusive so far despite the
40-years of intense researches. Here we use bulk-sensitive angle-resolved
photoemission spectroscopy and reveal the devil's staircase transition of the
electronic structures. The magnetic reconstruction dramatically alters the band
dispersions at each transition. We moreover find that the well-defined band
picture largely collapses around the Fermi energy under the long-periodic
modulation of the transitional phase, while it recovers at the transition into
the lowest-temperature ground state. Our data provide the first direct evidence
for a significant reorganization of the electronic structures and spectral
functions occurring during the devil's staircase.Comment: 22 pages, 5 figure
An ontological framework for cooperative games
Social intelligence is an emerging property of a system composed of agents that consists of the ability of this system to conceive, design, implement and execute strategies to solve problems and thus achieve a collective state of the system that is concurrently satisfactory for all and each one of the agents that compose it. In order to make decisions when dealing with complex problems related to social systems and take advantage of social intelligence, cooperative games theory constitutes the standard theoretical framework. In the present work, an ontological framework for cooperative games modeling and simulation is presented
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