91 research outputs found
The oil-dispersion bath in anthroposophic medicine – an integrative review
<p>Abstract</p> <p>Background</p> <p>Anthroposophic medicine offers a variety of treatments, among others the oil-dispersion bath, developed in the 1930s by Werner Junge. Based on the phenomenon that oil and water do not mix and on recommendations of Rudolf Steiner, Junge developed a vortex mechanism which churns water and essential oils into a fine mist. The oil-covered droplets empty into a tub, where the patient immerses for 15–30 minutes. We review the current literature on oil-dispersion baths.</p> <p>Methods</p> <p>The following databases were searched: Medline, Pubmed, Embase, AMED and CAMbase. The search terms were 'oil-dispersion bath' and 'oil bath', and their translations in German and French. An Internet search was also performed using Google Scholar, adding the search terms 'study' and 'case report' to the search terms above. Finally, we asked several experts for gray literature not listed in the above-mentioned databases. We included only articles which met the criterion of a clinical study or case report, and excluded theoretical contributions.</p> <p>Results</p> <p>Among several articles found in books, journals and other publications, we identified 1 prospective clinical study, 3 experimental studies (enrolling healthy individuals), 5 case reports, and 3 field-reports. In almost all cases, the studies described beneficial effects – although the methodological quality of most studies was weak. Main indications were internal/metabolic diseases and psychiatric/neurological disorders.</p> <p>Conclusion</p> <p>Beyond the obvious beneficial effects of warm bathes on the subjective well-being, it remains to be clarified what the unique contribution of the distinct essential oils dispersed in the water can be. There is a lack of clinical studies exploring the efficacy of oil-dispersion baths. Such studies are recommended for the future.</p
Anti-proliferative effect of Rosmarinus officinalis L. extract on human melanoma A375 cells
Rosemary (Rosmarinus officinalis L.) has been used since ancient times in traditional medicine, while nowadays various rosemary formulations are increasingly exploited by alternative medicine to cure or prevent a wide range of health disorders. Rosemary's bioproperties have prompted scientific investigation, which allowed us to ascertain antioxidant, anti-inflammatory, cytostatic, and cytotoxic activities of crude extracts or of pure components. Although there is a growing body of experimental work, information about rosemary's anticancer properties, such as chemoprotective or anti-proliferative effects on cancer cells, is very poor, especially concerning the mechanism of action. Melanoma is a skin tumor whose diffusion is rapidly increasing in the world and whose malignancy is reinforced by its high resistance to cytotoxic agents; hence the availability of new cytotoxic drugs would be very helpful to improve melanoma prognosis. Here we report on the effect of a rosemary hydroalcoholic extract on the viability of the human melanoma A375 cell line. Main components of rosemary extract were identified by liquid chromatography coupled to tandem mass spectrometry (LC/ESI-MS/MS) and the effect of the crude extract or of pure components on the proliferation of cancer cells was tested by MTT and Trypan blue assays. The effect on cell cycle was investigated by using flow cytometry, and the alteration of the cellular redox state was evaluated by intracellular ROS levels and protein carbonylation analysis. Furthermore, in order to get information about the molecular mechanisms of cytotoxicity, a comparative proteomic investigation was performed
A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers.
Pharmacology of rosemary (<i>Rosmarinus officinalis </i>Linn.) and its therapeutic potentials
124-130The use of plants
is as old as the mankind. Natural products are cheap and claimed to be safe. They
are also suitable raw material for production of new synthetic agents. Rosemary
(Rosmarinus officinalis Linn.) is a common household plant grown in many
parts of the world. It is used for flavouring food, a beverage drink, as well as
in cosmetics; in folk. medicine it is used as
an
antispasmodic in renal colic and dysmenorrhoea, in relieving respiratory disorders
and to stimulate growth of hair. Extract of rosemary relaxes smooth muscles of trachea
and intestine, and has choleretic, hepatoprotective and antitumerogenic activity.
The most important constituents of rosemary are caffeic acid and its derivatives
such as rosmarinic acid. These compounds have
antioxidant effect.
The phenolic compound, rosmarinic acid, obtains one of its phenolic rings from phenylalanine
via caffeic acid and the other from tyrosine via dihydroxyphenyl-lactic acid. Relatively
large-scale production of rosmarinic acid can be obtained from the cell culture
of Coleus blumei Benth when supplied exogenously with phenylalanine and
tyrosine. Rosmarinic acid is
well absorbed from gastrointestinal
tract and from the skin. It increases the production of prostaglandin Ez and reduces
the production of leukotriene B4 in human polymorphonuclear
leucocytes, and inhibits the complement system. It is concluded that rosemary
and its constituents especially caffeic acid derivatives such as rosmarinic acid
have a therapeutic potential in treatment or prevention of bronchial asthma,
spasmogenic disorders, peptic ulcer, inflammatory diseases, hepatotoxicity, atherosclerosis,
ischaemic heart disease, cataract, cancer and poor sperm motility.</span
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