Behavioral thermoregulation in the American lobster Homarus americanus

It is generally accepted that water temperature has a strong influence on the behavior of the American lobster Homarus americanus. However, there is surprisingly little behavioral evidence to support this view. To haracterize the behavioral responses of lobsters to thermal gradients, three different experiments were conducted. In the first, 40 lobsters acclimated to summer water temperatures (summer-acclimated, 15.5±0.2 °C, mean ±S.E.M.) were placed individually in an experimental shelter, and the temperature in the shelter was gradually raised until the lobster moved out. Lobsters avoided water warmer than 23.5±0.4 °C, which was an increase of 8.0±0.4 °C from ambient summer temperatures. When this experiment was repeated with lobsters acclimated to winter temperatures (winter-acclimated, 4.3±0.1 °C), the lobsters (N=30) did not find temperature increases of the same magnitude (∆T=8.0±0.4 °C) aversive. The second experiment was designed to allow individual summer-acclimated lobsters (N=22) to select one of five shelters, ranging in temperature from 8.5 to 25.5 °C. After 24 h, 68 % of the lobsters occupied the 12.5 °C shelter, which was slightly above the ambient temperature (approximately 11 °C). In a similar experiment, winter-acclimated lobsters (N=30) were given a choice between two shelters, one at ambient temperature (4.6±0.2 °C) and one at a higher temperature (9.7±0.3 °C). Winter-acclimated lobsters showed a strong preference (90 %) for the heated shelter. In the final experiment, summer-acclimated lobsters (N=9) were allowed to move freely in a tank having a thermal gradient of approximately 10 °C from one end to the other. Lobsters preferred a thermal niche of 16.5±0.4 °C and avoided water that was warmer than 19 °C or colder than 13 °C. When standardized for acclimation temperature, lobsters preferred water 1.2±0.4 °C above their previous ambient temperature. Collectively, the results of these studies indicate that lobsters are capable of sensing water temperature and use this information to thermoregulate behaviorally. The implications of these findings for lobster behavior and distribution in their natural habitat are discussed

THE APPROACH TO THE ANALYSIS OF ELECTRICAL FIELD DISTRIBUTION IN THE SETUP OF PAPER INSULATED ELECTRODES IN OIL

Article presents the problem of the approach to the analysis of electrical field distribution in the model insulating system, which, in the author's experimental research, was used to the assessment of the influence of paper insulation on the mechanism of electrical discharge initiation in mineral oil. The main assumptions of the planned numerical works based on the finite element method were described and scientific aim of the numerical analysis were characterized in this paper. Both the assumptions and the scientific aim were related to the conclusions from the experimental works, especially to the measured times to initiation of the discharges developing in mineral transformer oil, indicating on the important role of the oil quality in the process of discharge initiation in the system of the insulated by paper electrodes immersed in oil

Applications of Compound Nanotechnology and Twisted Inserts for Enhanced Heat Transfer

Nanoadditives are a type of heat transfer enhancement techniques adopted in heat exchangers to improve the performance of industrial plants through improvement of the thermal properties of base fluids. Recently, various types of inserts with nanofluids are adopted to enhance the thermal performance of double pipe heat exchangers. In the current article, TiO2/water nanofluid with multiple twisted tape inserts was investigated as a hybrid enhancement technique of heat transfer in straight pipes. The investigations were carried out experimentally and numerically at Reynolds numbers varied from 5000 to 20,000. Using nanofluid with 0.1% TiO2 nanoparticles volume fraction demonstrated enhanced heat transfer with slight increase in pressure drop. Results are showing a maximum increase of 110.8% in Nusselt number in a tube fitted with quintuple twisted tape inserts with 25.2% increase in the pressure drop. However, as the article is representing a part of specified book on heat exchangers, the literature has been extended to provide sufficient background to the reader on the use of nanotech, twisted inserts, and hybrid of compound nanofluids and inserts to enhance heat transfer processes

Religious faith and psychosocial adaptation among stroke patients in Kuwait: A mixed method study

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2012 Springer Science+Business Media.Religious faith is central to life for Muslim patients in Kuwait, so it may influence adaptation and rehabilitation. This study explored quantitative associations among religious faith, self-efficacy, and life satisfaction in 40 female stroke patients and explored the influence of religion within stroke rehabilitation through qualitative interviews with 12 health professionals. The quantitative measure of religious faith did not relate to life satisfaction or self-efficacy in stroke patients. However, the health professionals described religious coping as influencing adaptation post-stroke. Fatalistic beliefs were thought to have mixed influences on rehabilitation. Measuring religious faith among Muslims through a standardized scale is debated. The qualitative accounts suggest that religious beliefs need to be acknowledged in stroke rehabilitation in Kuwait

Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population

<p>Abstract</p> <p>Background</p> <p>The rs7903146 and rs12255372 variants of <it>TCF7L2 </it>have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date. Meta-analysis of 27 different studies has resulted in a global OR of 1.46 [1.42–1.51] (rs7903146 variant). Thus far, despite a high incidence of T2D, the role of this variant in Arabs has not been established.</p> <p>Methods</p> <p>We performed a case-control association study using 522 Saudi T2D patients (WHO criteria), and 346 controls (age > 60; fasting plasma glucose < 7 mmol/L). Genotyping was performed by pyrosequencing. Statistical analyses were performed using SPSS version 13.0 for Windows (SPSS, Chicago, IL, USA).</p> <p>Results</p> <p>For rs7903146, the T allele frequency of the cases (0.415) was not different from that observed in the controls (0.405). The crude odds ratio (OR) was 1.04 with a 95% CI of 0.86–1.27 (P = 0.675). For rs12255372, the T allele frequency of the cases (0.368) was not different from that observed in the controls (0.355). Retrospective power calculations based upon an OR of 1.46 reported in a comprehensive meta-analysis of <it>TCF7L2 </it>risk, indicated this study was sufficiently powered (96.92%; α = 0.05) to detect an effect of similar magnitude to that reported for rs7903146.</p> <p>Conclusion</p> <p>Our study is consistent with weak or no association of T2D in Arabs with the two <it>TCF7L2 </it>variants, however it cannot rule out an effect of other SNPs in this gene. Future studies in this population are required to confirm our findings and may indicate the presence of yet to be defined genetic risk factors for T2D.</p

Biochar optimizes wheat quality, yield, and nitrogen acquisition in low fertile calcareous soil treated with organic and mineral nitrogen fertilizers

Crop quality and nutrient uptake are considerably influenced by fertilizers inputs and their application rate. Biochar (BC) improves nitrogen uptake and crop productivity. However, its interaction with synthetic and organic fertilizers in calcareous soil is not fully recognized. Therefore, we inspected the role of biochar (0, 10, 20, and 30 t ha–1) in improving N uptake and quality of wheat in a calcareous soil under integrated N management (90, 120, and 150 kg N ha–1) applied each from urea, farmyard manure (FYM) and poultry manure (PM) along with control) in 2 years field experiments. Application of 20 t BC along with 150 kg N ha–1 as poultry manure considerably improved wheat grain protein content (14.57%), grain (62.9%), straw (28.7%), and biological (38.4%) yield, grain, straw, and total N concentration by 14.6, 19.2, and 15.6% and their uptake by 84.6, 48.8, and 72.1%, respectively, over absolute control when averaged across the years. However, their impact was more pronounced in the 2nd year (2016–2017) after application compared to the 1st year (2015–2016). Therefore, for immediate crop benefits, it is recommended to use 20 t BC ha–1 once in 50 years for enhancing the nitrogen use efficiency of fertilizers and crop yield

Global, regional, and national burden of chronic kidney disease, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and included incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings Globally, in 2017, 1·2 million (95% uncertainty interval [UI] 1·2 to 1·3) people died from CKD. The global all-age mortality rate from CKD increased 41·5% (95% UI 35·2 to 46·5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2·8%, −1·5 to 6·3). In 2017, 697·5 million (95% UI 649·2 to 752·0) cases of all-stage CKD were recorded, for a global prevalence of 9·1% (8·5 to 9·8). The global all-age prevalence of CKD increased 29·3% (95% UI 26·4 to 32·6) since 1990, whereas the age-standardised prevalence remained stable (1·2%, −1·1 to 3·5). CKD resulted in 35·8 million (95% UI 33·7 to 38·0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1·4 million (95% UI 1·2 to 1·6) cardiovascular disease-related deaths and 25·3 million (22·2 to 28·9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI

Development of a quality indicator set to measure and improve quality of ICU care in low- and middle-income countries

PURPOSE: To develop a set of actionable quality indicators for critical care suitable for use in low- or middle-income countries (LMICs). METHODS: A list of 84 candidate indicators compiled from a previous literature review and stakeholder recommendations were categorised into three domains (foundation, process, and quality impact). An expert panel (EP) representing stakeholders from critical care and allied specialties in multiple low-, middle-, and high-income countries was convened. In rounds one and two of the Delphi exercise, the EP appraised (Likert scale 1–5) each indicator for validity, feasibility; in round three sensitivity to change, and reliability were additionally appraised. Potential barriers and facilitators to implementation of the quality indicators were also reported in this round. Median score and interquartile range (IQR) were used to determine consensus; indicators with consensus disagreement (median < 4, IQR ≤ 1) were removed, and indicators with consensus agreement (median ≥ 4, IQR ≤ 1) or no consensus were retained. In round four, indicators were prioritised based on their ability to impact cost of care to the provider and recipient, staff well-being, patient safety, and patient-centred outcomes. RESULTS: Seventy-one experts from 30 countries (n = 45, 63%, representing critical care) selected 57 indicators to assess quality of care in intensive care unit (ICU) in LMICs: 16 foundation, 27 process, and 14 quality impact indicators after round three. Round 4 resulted in 14 prioritised indicators. Fifty-seven respondents reported barriers and facilitators, of which electronic registry-embedded data collection was the biggest perceived facilitator to implementation (n = 54/57, 95%) Concerns over burden of data collection (n = 53/57, 93%) and variations in definition (n = 45/57, 79%) were perceived as the greatest barrier to implementation. CONCLUSION: This consensus exercise provides a common set of indicators to support benchmarking and quality improvement programs for critical care populations in LMICs

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection