Saving energy in aggressive intrusion detection through dynamic latency sensitivity recognition

In an always connected world, cyber-attacks and computer security breaches can produce significant financial damages as well as introduce new risks and menaces in everyday's life. As a consequence, more and more sophisticated packet screening/filtering solutions are deployed everywhere, typically on network border devices, in order to sanitize Internet traffic. Despite the obvious benefits associated to the proactive detection of security threats, these devices, by performing deep packet inspection and inline analysis, may both affect latency-sensitive traffic introducing non-negligible delays, and increase the energy demand at the network element level. Starting from these considerations, we present a selective routing and intrusion detection technique based on dynamic statistical analysis. Our technique separates latency-sensitive traffic from latency-insensitive one and adaptively organizes the intrusion detection activities over multiple nodes. This allows suppressing directly at the network ingress, when possible, all the undesired components of latency-insensitive traffic and distributing on the innermost nodes the security check for latency sensitive flows, prioritizing routing activities over security scanning ones. Our final goal is demonstrating that selective intrusion detection can result in significant energy savings without adversely affecting latency-sensitive traffic by introducing unacceptable processing delays. \ua9 2017 Elsevier Ltd

HDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration

Tissue regeneration is associated with complex changes in gene expression and post-translational modifications of proteins, including transcription factors and histones that comprise chromatin. We tested 172 compounds designed to target epigenetic mechanisms in an axolotl (Ambystoma mexicanum) embryo tail regeneration assay. A relatively large number of compounds (N = 55) inhibited tail regeneration, including 18 histone deacetylase inhibitors (HDACi). In particular, romidepsin, an FDA-approved anticancer drug, potently inhibited tail regeneration when embryos were treated continuously for 7 days. Additional experiments revealed that romidepsin acted within a very narrow, post-injury window. Romidepsin treatment for only 1-minute post amputation inhibited regeneration through the first 7 days, however after this time, regeneration commenced with variable outgrowth of tailfin tissue and abnormal patterning. Microarray analysis showed that romidepsin altered early, transcriptional responses at 3 and 6-hour post-amputation, especially targeting genes that are implicated in tumor cell death, as well as genes that function in the regulation of transcription, cell differentiation, cell proliferation, pattern specification, and tissue morphogenesis. Our results show that HDAC activity is required at the time of tail amputation to regulate the initial transcriptional response to injury and regeneration

Dynamic latency sensitivity recognition: An application to energy saving

In the world of connected everything, network attacks and cyber-security breaches may cause huge monetary damages and even endanger lives; hence, full sanitization of the Internet traffic is a real necessity. In this paper we will apply a dynamic statistical analysis to separate latency sensitive traffic from the latency insensitive one at the source. Then, we will calculate the energy savings that can be achieved by identifying and dropping all the unwanted portion of the latency insensitive traffic directly at the source. This value represents an upper-bound to the actual amount of energy that can be saved by applying our adaptive aggressive intrusion detection technique to latency insensitive traffic, in fact the actual value depends on the actual load of the network and its capability to spread the hunt for malicious packet among all the network nodes. The main contribution of this paper is to show that energy savings through aggressive intrusion detection may be achieved without burdening latency sensitive traffic with delays that may render it unusable, nonetheless, as a side effect of early removal of unwanted traffic from the network flows is to reduce the network load, the traffic reduction so obtained allows sanitizing even the latency sensitive traffic with a reduced risk of excessive delays due to resources allocation and traffic forecasting errors

Use of Donor-derived Cell-free DNA to Inform Tapering of Immunosuppression Therapy in Kidney Transplant Recipients: An Observational Study

Background. Immunosuppression therapy (IST) is required for allograft survival but can cause significant adverse effects. Donor-derived cell-free DNA (dd-cfDNA) is a validated noninvasive biomarker for active rejection in kidney transplant (KTx). Evidence supporting dd-cfDNA testing use in IST management is limited. Methods. In this single-center observational study, dd-cfDNA testing was performed in 21 KTx patients considered good candidates for mycophenolic acid (MPA) reduction. Patients with dd-cfDNA <1% at the first visit (enrollment) had their MPA dosage reduced; those with dd-cfDNA ≥1% had their MPA dosage maintained. Patients were monitored with dd-cfDNA for 6 additional visits. Results. Of 21 patients enrolled in the study, 17 were considered low risk for rejection by dd-cfDNA and underwent MPA reduction; 4 patients were considered high risk for rejection by dd-cfDNA and had their initial MPA dosage maintained. Of the 4 patients considered high risk for rejection by dd-cfDNA, 1 experienced chronic allograft nephropathy and graft loss, and another received an indication biopsy that showed no evidence of rejection. Of the 17 patients considered low risk for rejection by dd-cfDNA, none experienced allograft rejection. dd-cfDNA was used for surveillance in a 6-mo period following MPA reduction; no untoward results were noted. Conclusions. This proof-of-concept study reports the use of dd-cfDNA to directly inform IST management in a cohort of KTx who were candidates for IST reduction

Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates.

In most tetrapod vertebrates, limb skeletal progenitors condense with postaxial dominance. Posterior elements (such as ulna and fibula) appear prior to their anterior counterparts (radius and tibia), followed by digit-appearance order with continuing postaxial polarity. The only exceptions are urodele amphibians (salamanders), whose limb elements develop with preaxial polarity and who are also notable for their unique ability to regenerate complete limbs as adults. The mechanistic basis for this preaxial dominance has remained an enigma and has even been proposed to relate to the acquisition of novel genes involved in regeneration. However, recent fossil evidence suggests that preaxial polarity represents an ancestral rather than derived state. Here, we report that 5\u27Hoxd (Hoxd11-d13) gene deletion in mouse is atavistic and uncovers an underlying preaxial polarity in mammalian limb formation. We demonstrate this shift from postaxial to preaxial dominance in mouse results from excess Gli3 repressor (Gli3R) activity due to the loss of 5\u27Hoxd-Gli3 antagonism and is associated with cell-cycle changes promoting precocious cell-cycle exit in the anterior limb bud. We further show that Gli3 knockdown in axolotl results in a shift to postaxial dominant limb skeleton formation, as well as expanded paddle-shaped limb-bud morphology and ensuing polydactyly. Evolutionary changes in Gli3R activity level, which also played a key role in the fin-to-limb transition, appear to be fundamental to the shift from preaxial to postaxial polarity in formation of the tetrapod limb skeleton