28 research outputs found
Time-evolution of in vivo protein corona onto blood-circulating PEGylated liposomal doxorubicin (DOXIL) nanoparticles
Nanoparticles (NPs) are instantly modified once injected in the bloodstream because of their interaction with the blood components. The spontaneous coating of NPs by proteins, once in contact with biological fluids, has been termed the ‘protein corona’ and it is considered to be a determinant factor for the pharmacological, toxicological and therapeutic profile of NPs. Protein exposure time is thought to greatly influence the composition of protein corona, however the dynamics of protein interactions under realistic, in vivo conditions remain unexplored. The aim of this study was to quantitatively and qualitatively investigate the time evolution of in vivo protein corona, formed onto blood circulating, clinically used, PEGylated liposomal doxorubicin. Protein adsorption profiles were determined 10 min, 1 h and 3 h post-injection of liposomes into CD-1 mice. The results demonstrated that a complex protein corona was formed as early as 10 min post-injection. Even though the total amount of protein adsorbed did not significantly change over time, the fluctuation of protein abundances observed indicated highly dynamic protein binding kinetics
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A novel scavenging tool for cancer biomarker discovery based on the blood-circulating nanoparticle protein corona
Beautiful Mirrors at the LHC
We explore the "Beautiful Mirrors" model, which aims to explain the measured
value of , discrepant at the level. This scenario
introduces vector-like quarks which mix with the bottom, subtly affecting its
coupling to the . The spectrum of the new particles consists of two
bottom-like quarks and a charge -4/3 quark, all of which have electroweak
interactions with the third generation. We explore the phenomenology and
discovery reach for these new particles at the LHC, exploring single mirror
quark production modes whose rates are proportional to the same mixing
parameters which resolve the anomaly. We find that for mirror quark
masses is required to
reasonably establish the scenario and extract the relevant mixing parameters.Comment: version to be published in JHE
Anomalous coupling effects in exclusive radiative B-meson decays
The top-quark FCNC processes will be searched for at the CERN LHC, which are
correlated with the B-meson decays. In this paper, we study the effects of
top-quark anomalous interactions in the exclusive radiative and decays. With the current experimental data of
the branching ratios, the direct CP and the isospin asymmetries, bounds on the
coupling from and
from decays are derived,
respectively. The bound on from is generally compatible with that from . However, the isospin asymmetry further
restrict the phase of , and the combined bound results
in the upper limit, , which is lower than the
CDF result. For real , the upper bound on is about of the same order as the discovery
potential of ATLAS with an integrated luminosity of . For
decays, the NP contribution is enhanced by a large CKM factor
, and the constraint on coupling is rather
restrictive, . With refined
measurements to be available at the LHCb and the future super-B factories, we
can get close correlations between and the rare
decays, which will be studied directly at the LHC ATLAS and CMS.Comment: 25 pages, 15 figures, pdflate
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Maternal exposure to PM2.5 induces cognitive impairment in offspring via cerebellar neuroinflammation and oxidative stress
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The emergence of nanopharmacy: from biology to nanotechnology and drug molecules to nanodrugs
Sand Dune Encroachment and Desertification Processes of the Rigboland Sand Sea, Central Iran
Early studies on sand dune movement and desertification in Iran have not always been convincingly demonstrated because of problems with the field-based measurements. In some areas where various land uses have been engulfed by aeolian sand dunes, desertification is clear, but in other less settled areas, it may not be so obvious. The objective of this study is to demonstrate encroachments of the Rigboland sand sea, central Iran, in its different directions and variable magnitude rates. Determining the rate and direction of the sand sea movements is critical for specifying which lands should be prioritized and quickly protected. The study has trialed a change detection technique which uses a Cross-Tabulation module to compare two available LandsatTM images over the Rigboland sand sea. This indicates that within a ten-year span (from 1988 to 1998) more than 200 ha/yr were added to the Rigboland sand sea, from the alluvial fan landforms in the eastern upstream, outer margins of the Rigboland sand sea. Coupled with GIS techniques, this type of analysis of the remote sensing (RS) images provides an effective tool for the monitoring and prognostication of sand dune movement and sand sea change.</p