The successful implementation of e-government transformation: A case study in Oman

The aim of this paper is to investigate, and to discuss the key critical factors that facilitate the successful implementation of E-government projects. The nature of this research is mainly qualitative. This investigation uses a single case study and data was mainly collected by means of semi-structured interviews and organisational documents from the Ministry of Higher Education in Oman. The research findings suggest that there are three paradigms which each include a set of factors that impacts the success of E-government success namely, organisational paradigm, technology paradigm and end-users paradigm. The authors believe that, this paper demonstrates an added value to the current literature on transformation of E-government and to E-government projects success, within the wider context of E-government implementation projects. Also the research will benefit organisations in the public sector, as it has identified main key success factors in E-government transformations and implementations

Client-server-based LBS architecture: A novel positioning module for improved positioning performance

Permission to distribute obtained from publisher.This work presents a new efficient positioning module that operates over client-server LBS architectures. The aim of the proposed module is to fulfil the position information requirements for LBS pedestrian applications by ensuring the availability of reliable, highly accurate and precise position solutions based on GPS single frequency (L1) positioning service. The positioning module operates at both LBS architecture sides; the client (mobile device), and the server (positioning server). At the server side, the positioning module is responsible for correcting user’s location information based on WADGPS corrections. In addition, at the mobile side, the positioning module is continually in charge for monitoring the integrity and available of the position solutions as well as managing the communication with the server. The integrity monitoring was based on EGNOS integrity methods. A prototype of the proposed module was developed and used in experimental trials to evaluate the efficiency of the module in terms of the achieved positioning performance. The positioning module was capable of achieving a horizontal accuracy of less than 2 meters with a 95% confidence level with integrity improvement of more than 30% from existing GPS/EGNOS services

Structural validation of oral mucosal tissue using optical coherence tomography

Background: Optical coherence tomography (OCT) is a non-invasive optical technology using near-infrared light to produce cross-sectional tissue images with lateral resolution. Objectives: The overall aims of this study was to generate a bank of normative and pathological OCT data of the oral tissues to allow identification of cellular structures of normal and pathological processes with the aim to create a diagnostic algorithm which can be used in the early detection of oral disorders. Material and methods: Seventy-three patients with 78 suspicious oral lesions were referred for further management to the UCLH Head and Neck Centre, London. The entire cohort had their lesions surgically biopsied (incisional or excisional). The immediate ex vivo phase involved scanning the specimens using optical coherence tomography. The specimens were then processed by a histopathologist. Five tissue structures were evaluated as part of this study, including: keratin cell layer, epithelial layer, basement membrane, lamina propria and other microanatomical structures. Two independent assessors (clinician and pathologist trained to use OCT) assessed the OCT images and were asked to comment on the cellular structures and changes involving the five tissue structures in non-blind fashion. Results: Correct identification of the keratin cell layer and its structural changes was achieved in 87% of the cohort; for the epithelial layer it reached 93.5%, and 94% for the basement membrane. Microanatomical structures identification was 64% for blood vessels, 58% for salivary gland ducts and 89% for rete pegs. The agreement was “good” between the clinician and the pathologist. OCT was able to differential normal from pathological tissue and pathological tissue of different entities in this immediate ex vivo study. Unfortunately, OCT provided inadequate cellular and subcellular information to enable the grading of oral premalignant disorders. Conclusion: This study enabled the creation of OCT bank of normal and pathological oral tissues. The pathological changes identified using OCT enabled differentiation between normal and pathological tissues, and identification of different tissue pathologies. Further studies are required to assess the accuracy of OCT in identification of various pathological processes involving the oral tissues

Defining family business efficacy: an exploratory study

In today’s competitive environment, the growth and survival of family firms depend significantly on the extent to which they can build, extend, or reconfigure organisational capabilities in response to changing environments. Family members’ belief in their unified efforts to organise and execute courses of action can be instrumental in addressing business and marketing challenges and goals. This study aims to conceptualise a novel Family Business Efficacy (FBE) construct that is posited as a distinct form of efficacy at the collective level in family firms. The research employs a qualitative inductive design to investigate FBE of family businesses in Saudi Arabia and the UK. The findings identify eight dimensions of FBE that reflect family members’ beliefs regarding collective abilities to produce desired marketing outcomes for the family business. This paper contributes a conceptualisation of FBE as the basis for scale measurement and further empirical assessment of FBE on firm marketing performance

Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons

Zolpidem, a GABAA receptor-positive modulator, is the gold-standard drug for treating insomnia. Zolpidem prolongs IPSCs to decrease sleep latency and increase sleep time, effects that depend on α2 and/or α3 subunit-containing receptors. Compared with natural NREM sleep, zolpidem also decreases the EEG power, an effect that depends on α1 subunit-containing receptors, and which may make zolpidem-induced sleep less optimal. In this paper, we investigate whether zolpidem needs to potentiate only particular GABAergic pathways to induce sleep without reducing EEG power. Mice with a knock-in F77I mutation in the GABAA receptor γ2 subunit gene are zolpidem-insensitive. Using these mice, GABAA receptors in the frontal motor neocortex and hypothalamic (tuberomammillary nucleus) histaminergic-neurons of γ2I77 mice were made selectively sensitive to zolpidem by genetically swapping the γ2I77 subunits with γ2F77 subunits. When histamine neurons were made selectively zolpidem-sensitive, systemic administration of zolpidem shortened sleep latency and increased sleep time. But in contrast to the effect of zolpidem on wild-type mice, the power in the EEG spectra of NREM sleep was not decreased, suggesting that these EEG power-reducing effects of zolpidem do not depend on reduced histamine release. Selective potentiation of GABAA receptors in the frontal cortex by systemic zolpidem administration also reduced sleep latency, but less so than for histamine neurons. These results could help with the design of new sedatives that induce a more natural sleep

Model Checking Tap Withdrawal in C. Elegans

We present what we believe to be the first formal verification of a biologically realistic (nonlinear ODE) model of a neural circuit in a multicellular organism: Tap Withdrawal (TW) in \emph{C. Elegans}, the common roundworm. TW is a reflexive behavior exhibited by \emph{C. Elegans} in response to vibrating the surface on which it is moving; the neural circuit underlying this response is the subject of this investigation. Specifically, we perform reachability analysis on the TW circuit model of Wicks et al. (1996), which enables us to estimate key circuit parameters. Underlying our approach is the use of Fan and Mitra's recently developed technique for automatically computing local discrepancy (convergence and divergence rates) of general nonlinear systems. We show that the results we obtain are in agreement with the experimental results of Wicks et al. (1995). As opposed to the fixed parameters found in most biological models, which can only produce the predominant behavior, our techniques characterize ranges of parameters that produce (and do not produce) all three observed behaviors: reversal of movement, acceleration, and lack of response

Existence and stability theories for a coupled system involving p-Laplacian operator of a nonlinear Atangana–Baleanu fractional differential equations

We investigate the appropriate and sufficient conditions for the existence and uniqueness of a solution for a coupled system of Atangana–Baleanu fractional equations with a p-Laplacian operator. We also study the HU-stability of the solution by using the Atangana–Baleanu–Caputo (ABC) derivative. To achieve these goals, we convert the coupled system of Atangana–Baleanu fractional equations into an integral equation form with the help of Green functions. The existence of the solution is proven by using topological degree theory and Banach’s fixed point theorem, with which we analyze the solution’s continuity, equicontinuity and boundedness. Then, we use Arzela–Ascolli theory to ensure that the solution is completely continuous. Uniqueness is established using the Banach contraction principle. We also investigate several adequate conditions for HU-stability and generalized HU-stability of the solution. An illustrative example is presented to verify our results

Damage identification in a concrete beam using curvature difference ratio

Previous studies utilising changes in mode shape or curvature to locate damage rely on the fact that the greatest change occurs around the defect. However, in concrete beams this fact is undermined due to the nature of the defect as distributed multi-site cracks. In addition, differences in mode shape and curvature as ways to locate the damage is unstable because of occurrence of modal nodes and inflection points. In this paper, one interesting solution to this problem is being tested by establishing a new non-dimensional expression designated the 'Curvature Difference Ratio (CDR)'. This parameter exploits the ratio of differences in curvature of a specific mode shape for a damaged stage and another reference stage. The expression CDR is reasonably used to locate the damage and estimate the dynamic bending stiffness in a successively loaded 6m concrete beam. Results obtained by the proposed technique are tested and validated with a case study results done by Ren and De Roeck [1] also by Maeck and De Roeck [2]. Another contribution of this work is that relating changes in vibration properties to the design bending moment at beam sections as defined in Eurocode 2 specifications [3]. Linking between a beam section condition and the change in vibration data will help to give a better comprehension on the beam condition than the applied load

Epithelial tissue thickness improves optical coherence tomography's ability in detecting oral cancer

BACKGROUND OCT is a non-invasive imaging technique that enables the measurement of epithelial thickness and architectural changes, which can help in the diagnosis of pre-cancerous and cancerous lesions. The purpose of the study was to assess whether epithelial tissue thickness improves optical coherence tomography’s ability in detecting oral cancer. PATIENTS AND METHODS Surgically resected oral margins from 60 patients diagnosed with oral squamous cell carcinoma were subjected to OCT. Three OCT measurements (immediate, 1 h and 24 h post-resection) were conducted per resected tissue specimen to look at the effect of saline and formalin on the specimen and its effect on the reproducibility of the OCT. OCT was, then, used to measure the epithelial tissue thickness in cancer-free and cancer-involved margins in eight oral anatomical locations. This data was, then, combined with architectural changes data to calculate the sensitivity and specificity. RESULTS An overall of 189 cancer-free margins and 51 cancer-involved margins had their epithelial thickness measured using OCT and compared to histopathology. With regards to the validity of the OCT and histopathological measurements, epithelial thickness showed good correlation between different readings at all oral sites. With regards to the reproducibility of the OCT measurements, the mean epithelial thickness for all measurements at first (immediate) and second (1 h post-resection – saline preserved) measurements was not significantly different. Underestimation of the epithelial depth in cancer-free margins was 20 μm, while in the cancer-involved margins was 10 μm. Combining data from architectural changes and epithelial thickness, a sensitivity of 92% and a specificity of 94% was achieved. CONCLUSION Oral epithelium measurements using OCT were valid compared to those made with gold standard pathology. Measurements made using OCT was also reproducible with minor underestimation. Epithelial thickness, combined with architectural changes, led to high accuracy in differentiating between cancer-free and cancer-involved margins