In Vitro Interaction Between Oral Hypoglycemic Drug And Herbal Sex Stimulants: Drug Interactions

Sexual dysfunction is a common, underappreciated complication of diabetes. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunction (ED). All three forms of male dysfunction can cause significant bother for diabetic patients and can affect their quality of life. Diabetic patients take oral hypoglycemic drug to control their diabetic as well as take herbal sex stimulants to control to increase the libido. The combined use of herbs and drugs has increased the possibility of herb-drug interactions. The study was undertaken to explore the herb-drug interactions. To investigate the herbdrug interactions an in vitro dissolution study in different simulated pH medium were performed. In this study gliclazide containing tablet of 80mg as oral hypoglycemic drug and different herbal sex stimulants available in local market were used. The release mechanism was explored and explained with zero order, first order and Higuchi equations to identify drug interaction. Higher percentage release of gliclazide was found at simulated phosphate buffer of pH 7.4 compared to gastric medium of pH 1.2 and also in presence of herbal sex stimulants. Increased release pattern of gliclazide by concomitant administration of herbal sex stimulants gives slightly higher absorption, which gives the indication of herb-drug interactions

COMPARATIVE ADSORPTION STUDY ON RICE HUSK AND RICE HUSK ASH BY USING AMARANTHUS GANGETICUS PIGMENTS AS DYE

Low cost adsorbents such as Rice Husk (RH) and Rice Husk Ash (RHA) were used for removing dyes from aqueous medium and later Linear, Langmuir and Freundlich adsorption isotherms have been verified by using adsorption data. RH was activated by treating with nitric acid and RHA was prepared from RH by dolomite process. Natural dyes were extracted from the vegetable Amaranthus gangeticus by using a standard method. The removal efficiency of adsorbents was measured for the variation of parameters pH, contact time and adsorbents concentration. It has been noted that after changing time for same amount of adsorbent (1g/100ml) and dyes (10 ml) RH gave no efficiency trend but increased to 43.91% whereas for RHA efficiency was gradually increased to 59.62%. A reverse trend was noted when adsorption amounts were changed and others were put constant where RHA efficiency gradually increased to 99.30% but RH gave no trend with highest efficiency was close to 61.85%. The RH removal efficiency was good for pH 11 close to 62.86% and it was continuous from 3.95% at pH 2. Alternately, RHA gave 80.21% at pH 2 and later was decreased to 1.5% at pH 9 and again increased from pH 11. It is noted that RHA removal efficiency is better than RH and adsorptions are well fitted with isotherms

COMPARATIVE ADSORPTION STUDY ON RICE HUSK AND RICE HUSK ASH BY USING AMARANTHUS GANGETICUS PIGMENTS AS DYE

Low cost adsorbents such as Rice Husk (RH) and Rice Husk Ash (RHA) were used for removing dyes from aqueous medium and later Linear, Langmuir and Freundlich adsorption isotherms have been verified by using adsorption data. RH was activated by treating with nitric acid and RHA was prepared from RH by dolomite process. Natural dyes were extracted from the vegetable Amaranthus gangeticus by using a standard method. The removal efficiency of adsorbents was measured for the variation of parameters pH, contact time and adsorbents concentration. It has been noted that after changing time for same amount of adsorbent (1g/100ml) and dyes (10 ml) RH gave no efficiency trend but increased to 43.91% whereas for RHA efficiency was gradually increased to 59.62%. A reverse trend was noted when adsorption amounts were changed and others were put constant where RHA efficiency gradually increased to 99.30% but RH gave no trend with highest efficiency was close to 61.85%. The RH removal efficiency was good for pH 11 close to 62.86% and it was continuous from 3.95% at pH 2. Alternately, RHA gave 80.21% at pH 2 and later was decreased to 1.5% at pH 9 and again increased from pH 11. It is noted that RHA removal efficiency is better than RH and adsorptions are well fitted with isotherms

Ring-opening copolymerization of ε-caprolactone and δ-valerolactone by a titanium-based metal-organic framework

Metal organic frameworks (MOFs) are not much investigated as catalysts in copolymer formation with cyclic esters. Herein, we report the ring-opening copolymerization of epsilon-caprolactone (CL) with delta-valerolactone (VL) using a recoverable and reusable Ti-metal based MOF, MIL-125 without any co-catalyst in a solvent-free medium. The synthesized copolymers are random in nature, exhibit lower crystallinity than those of the corresponding homo-polymers, and are totally free from metal contamination, which was established by a series of appropriate experiments and characterization techniques