Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

The response to the coronavirus disease 2019 (COVID-19) pandemic has been hampered by lack of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral therapy. Here we report the use of remdesivir in a patient with COVID-19 and the prototypic genetic antibody deficiency X-linked agammaglobulinaemia (XLA). Despite evidence of complement activation and a robust T cell response, the patient developed persistent SARS-CoV-2 pneumonitis, without progressing to multi-organ involvement. This unusual clinical course is consistent with a contribution of antibodies to both viral clearance and progression to severe disease. In the absence of these confounders, we take an experimental medicine approach to examine the in vivo utility of remdesivir. Over two independent courses of treatment, we observe a temporally correlated clinical and virological response, leading to clinical resolution and viral clearance, with no evidence of acquired drug resistance. We therefore provide evidence for the antiviral efficacy of remdesivir in vivo, and its potential benefit in selected patients

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United Kingdom healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses and a sustained B and T cell response to the spike protein. NAb levels were higher after the extended dosing interval (6–14 weeks) compared with the conventional 3- to 4-week regimen, accompanied by enrichment of CD4+ T cells expressing interleukin-2 (IL-2). Prior SARS-CoV-2 infection amplified and accelerated the response. These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective immunogenic protocol

Dietary Habits of Students in Bangladesh Agricultural University and their Association with Overweight and Obesity

Purpose: The dietary habits of young adults have been affected; thus, overweight and obesity are increasingly being observed among the young. The purpose of this study is to assess the prevalence of overweight and obesity on a sample of students from the Bangladesh Agricultural University (BAU) and to examine their eating habits. Background: In the past year BAU has been experiencing a nutritional transition in food decisions from the everyday diet to the alimentation pattern. As a consequence, the dietary habits of young adults have been affected with progressive overweight and obesity .The purpose of this study is to assess the prevalence on a sample of MS stidents from BAU and to look at their uptake habits. Methods: A cross-sectional survey of 146 students were chosen randomly from the BAU throughout the JJ/2018 semester. With a 7 Days twenty four Hour Food frequency questionnaire where their Height, weight, dietary habits, Body mass index (BMI) were recorded. Statistical analyses were performed exploitation the Statistical Package for Social Sciences computer code (version 22.0) to determine overweight and obesity among students and to categorize uptake habits of food. Results: This study showed that the majority of the students (80.4%) were of normal weight (80.8% male students compared to 80% female students). The prevalence of overweight and obesity was 9.1% and 2.3% respectively .In contrast, 15.0% female students were underweight as compared to 3.8% males. Eating habits of the students showed that the majority (61.4%) reported taking meals regularly. There was a colored vegetable and fruits were intake scarcity among students. A total of 30.5% reported daily intake of colored vegetables with gender differences (P=.003) (31.5% females vs. 29.2% males). These prevalence rates were greater in girls than boys. There were no clear associations observed between dietary habits and measures of overweight and obesity. Conclusion: The overall low prevalence of overweight and obesity in the studied sample, indicate that university students would possibly benefit from nutrition and health promotion program to improve student’s eating habits.  There is a Significant differences observed among food type and frequency of consumption

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

The response to the coronavirus disease 2019 (COVID-19) pandemic has been hampered by lack of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral therapy. Here we report the use of remdesivir in a patient with COVID-19 and the prototypic genetic antibody deficiency X-linked agammaglobulinaemia (XLA). Despite evidence of complement activation and a robust T cell response, the patient developed persistent SARS-CoV-2 pneumonitis, without progressing to multi-organ involvement. This unusual clinical course is consistent with a contribution of antibodies to both viral clearance and progression to severe disease. In the absence of these confounders, we take an experimental medicine approach to examine the in vivo utility of remdesivir. Over two independent courses of treatment, we observe a temporally correlated clinical and virological response, leading to clinical resolution and viral clearance, with no evidence of acquired drug resistance. We therefore provide evidence for the antiviral efficacy of remdesivir in vivo, and its potential benefit in selected patients