Developing a new execution strategy for the production of zoning parcels according to the parcel plan

Arazi ve Arsa Düzenlemeleri (AAD), planlı şehircilik ilkeleri kapsamında uygulaması yerel yönetimlerce zorunlu olan uygulamalar kapsamındadır. Bu uygulamayla birçok parselin, parsel maliklerinden izin alınmaksızın İmar Kanunun 18. Maddesi ve uygulama yönetmeliği ile Planlı Alanlar Yönetmeliği hükümlerine ve uygulama imar planına göre parselasyonu yapılarak yapılaşmaya uygun hale getirilmektedir. Günümüz meri mevzuatı kapsamında parselasyon planına göre müstakil yapı yapılmasına müsait tapuya tescilli imar parseli üretimine ilişkin uygulamalar alan esaslı ve kısmen değer esaslı olarak yapılmakta olup her parselde eşit oranda değer artışı olduğu kabul edilmektedir. Ancak; bu durum her zaman her uygulamada sağlanamamaktadır ve bazı parsellerde diğer parsellere göre daha farklı değer artışları yaşandığı için hukuk dilinde haksız zenginleşmeye yol açmaktadır. İmar uygulamaları çalışmalarında alan esaslı çalışma yerine taşınmazın kadastro ve imar parsel değerlerine göre derece dönüşüm esaslı uygulama stratejisi geliştirilmiş, haksız zenginleşmeyi önleyebilecek daha adil bir model oluşturulmuştur. Çalışmada; Erzurum Büyükşehir Belediyesince kesinleştirilip tapu müdürlüğünce tescil edilen gerçek bir imar uygulaması incelenerek, her parselden eşit Düzenleme Ortaklık Payı (DOP) kesintisi uygulamasına alternatif olacak şekilde, kadastro ve imar parsellerinin değerlerinin oranlanmasından derece dönüşüm modeli geliştirilmiş, imar parseli tahsisinde 1163 sayılı Kooparatifler Kanununun 23. Maddesine uygun olarak şerefiye esaslı tahsis modeli uygulanmış ve imar uygulaması nedeniyle oluşan değer artışı malikler arasında paylaştırılarak değer eşitliği sağlanmıştır.Land arrangements (LA) is within the scope of practices that are mandatory by local governments within the scope of planned urbanism principles. With this application; Cadastral parcels are made suitable for construction by subdividing them according to the zoning legislation and implementation zoning plan, without obtaining permission from the parcel owners. Within the scope of today's Turkish legislation; Applications for the production of zoning parcels, which are suitable for detached structures according to the parceling plan and registered with the title deed, are made on an area-based basis and it is accepted that there is an equal increase in value in each parcel. However; Equal increase in value cannot be achieved in every application and since some parcels experience different value increases compared to other parcels, it leads to unjust enrichment in the language of law. In the zoning implementation studies, an application strategy based on degree conversion has been developed according to the cadastral and zoning parcel values of the real estate instead of the area-based work. Thus, a fairer model has been created that can prevent unjust enrichment. In the study, a real zoning application, which was finalized by the Erzurum Metropolitan Municipality and registered by the land registry directorate, was examined. In practice; As an alternative to the application of equal Regulation Partnership Share (RPS) deduction from each parcel, a degree conversion model has been developed from the ratio of the values of the cadastral and zoning parcels. In this study, goodwill-based allocation model has been applied

Case report of radiation-induced lung injury with trastuzumab emtansine: the lung also matters

With an increase in the number of agents used concurrently with radiotherapy (RT), a new research area has emerged regarding toxicity. Here, we present a case of a 47-year-old woman presenting with radiation-induced lung injury (RILI) that occurred six months after the end of RT with concomitant and sequential use of trastuzumab-emtansine (T-DM1) with RT. The patient’s T-DM1 treatment was discontinued because of RILI. Antibiotic and methylprednisolone treatments were started. The steroid dose was gradually tapered and completely discontinued after full recovery. If new agents are used concurrently with RT, the toxicity profile of new agents should be kept in mind

Baseline aortic pre-ejection interval predicts reverse remodeling and clinical improvement after cardiac resynchronization therapy

Background: Cardiac resynchronization therapy (CRT) has been shown to reduce heart failure-related morbidity and mortality. However, approximately one in three patients do not respond to CRT. The aim of the current study was to determine the parameter(s) which predict reverse remodeling and clinical improvement after CRT. Methods: A total of 54 patients (43 male, 11 female; mean age 61.9 ± 10.5 years) with heart failure and New York Heart Association (NYHA) class III–IV symptoms and in whom left ventricular ejection fraction (LVEF) was £ 35% and QRS duration was ≥ 120 ms, despite optimal medical therapy, were enrolled. An echocardiographic examination was performed before, and six months after, CRT. An echocardiographic response was defined as a reduction of end-systolic volume ≥ 10% after six months, and a clinical response was defined as a reduction ≥ 1 in the NYHA functional class score. Results: An echocardiographic response was observed in 38 (70.4%) of the patients and a clinical response occurred in 41 (75.9%) of the patients. Of the dyssynchrony parameters, only the aortic pre-ejection interval (APEI) was observed to significantly predict the clinical response (p = 0.048) and echocardiographic response (p = 0.037). A 180.5 ms cut-off value for the APEI predicted the clinical response with a sensitivity of 92.3% and a specificity of 39%, and the echocardiographic response with a sensitivity of 93.0% and a specificity of 42%. Conclusions: APEI derived from pulsed-wave Doppler, which is available in every echocardiography machine, is a simple and practical method that could be used to select patients for CRT. (Cardiol J 2011; 18, 6: 639–647

The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors

Objective: The development of bioinformatics and comprehensive genomic profiling (CGP) has provided insights into the ap-plicability and functionality of the genomic alterations (GA). In this study, we evaluated the impact of CGP on the treatment plan and outcomes in a significant number of patients. Material and Methods: We carried out a retrospective case-control study on 164 adult patients with advanced solid tumors from 15 oncology centers in Türkiye. Results: In all cases, CGP was performed within 23.8 [standard deviation (SD)±32.1] months of initial diagnosis. Non-small cell lung carcinoma, breast cancer, unknown primary carcinoma, colorectal carcinoma, and sarcoma were among the most common tumor types, accounting for 61.5% of all cases. CGP was performed immediately after the diagnosis of advanced cancer in 13 patients (7.9%). In 158 patients (96.4%), at least one GA was found as per the CGP report. Also, in the reports, the average tumor mutational burden (TMB) and GAs were 7.3 (SD±8.7) mut/Mb and 3.5 (SD±2.0), respectively. According to CGP reports, 58 patients had 79 evidence-based drug suggestions for their particular tumor type, whereas 97 patients had 153 evidence-based drug suggestions for another tumor type. After the primary oncologist interpreted the CGP reports, significant changes were made to the treatment of 35 (21.3%) patients. Conclusion: We strongly believe that in the future, high-TMB or other tumor-agnostic biomarkers will become much more afford-able, and CGP will serve as one of the major decision-making tools for the treatment of patients along with pathological, radiological or lab-oratory tests

Honey Plants of Düzce University Ornamental and Medicinal Plants Botanical Garden

In this study, melliferous plants that the honey bee (Apis mellifera L.) can benefit from among the taxa planted in Düzce University Ornamental and Medicinal Plants Botanical Garden, are presented. Among the 451 taxa planted in the botanical garden, those with these characteristics were determined by reviewing studies on the subject. Of the 165 taxa (36.58%) included in the honey plant class; 119 contain both nectar and pollen, 25 contain pollen, 13 contain nectar, 4 contain both pollen and insect secretion (IS) or sweet sap (SS), 2 contain pollen, nectar and IS or SS, 1 contain both nectar and SS, 1 contain only IS. In order to prevent the decrease in pollinator and pollinator insects, whose numbers are decreasing due to global climate change, a "Bee and Insect Hotel" was placed in the botanical garden. For this reason, the majority of the plants selected for planting were chosen from taxa with honey plant properties. The main purpose here is both to pollinate the plants in the botanical garden and to show and explain the effects of insect species on pollination through nature education

CFD MODELLING OF INDUSTRIAL AIR CURTAINS WITH HEATING UNIT

Industrial air curtains are used to prevent air from moving from one space to another space or to environment. The most common used type is downward-facing blower fan mounted over the entrance of a building, or an opening door between two spaces conditioned at different temperatures. In many factories and industrial buildings, heating or cooling applications are difficult due to the huge doors. These huge doors cause heat loses with convection phenomena of the inside air. In this study an air curtain having heater unit is analyzed numerically by CFD. The height of the air curtain from the bottom side is vary between 2.5 m, 3 m, 4m, 5m and 6 m mounted over the entrance door of the conditioned volume. For CFD studies proper mesh structure is created on the flow domain and Shear Stress Transport (SST) k-omega models were used in Unsteady Reynolds Averaged Navier-Stokes (URANS) computations. The blowing temperature of the air curtain has adjusted to 60 °C with the inside temperature was aimed to kept at +7°C while the outside temperature was -5°C. It is found that there is less flow occurred to the environment from conditioned volume at 2.5 3, 4 and 5 meter height cases. In these cases, the air curtain also contributes the heating of the conditioned room. But some ratio of the air flows through the atmosphere and the room cannot kept at the +7°C initial temperature at 6 m case. It is also found that the heating ratio at different blowing heights differs between 0,89-1,98 comparing the case without an air curtain

Experimental and Numerical Investigation of Flow Structures around Cylindrical Bluff Bodies

The understanding and quantitative prediction of velocity and pressure fluctuations in turbulent flows around such bluff bodies have been evolving over the years. The main aim of the present work is to investigate experimentally and numerically the flow field in the wake region of different bluff bodies such as circular, square and triangle cross section cylinders placed horizontally perpendicular to the uniform flow. The experimental studies were performed by Particle Image Velocimetry (PIV) method in an open water channel at Reynolds numbers 5000 and 10000 defined according to the characteristic lengths of the cylinders in the facilities of Selcuk University of Advanced Technology Research and Application Center in Turkey. The experimental results are compared to the numerical results obtained by means of transient simulation with LES turbulence model of ANSYS-Fluent Software. It is shown that the numerical and experimental results have a good agreement in respect of the instantaneous and time-averaged flow field patterns of vorticity, velocity component streamwise direction and streamline topology. In addition, drag coefficient of the geometries were also numerically calculated. For all geometries the wake length in x and y directions and size of the foci of the streamlines are decreasing by increasing Reynolds numbers in time-averaged results. The time-averaged flow patterns of both experimental and numerical results have considerable symmetry with respect to the centerline of each cylinder. Contours of the time-averaged stream wise velocity for Re=10000 demonstrate that the stagnation point around the symmetry plane moves further upstream for all cylinders in accordance with Re=5000. The maximum drag coefficient value was yielded for the square cross-section cylinder as 1.78 due to the sharp-edged geometry

Experimental and Numerical Investigation of Flow Structures around Cylindrical Bluff Bodies

The understanding and quantitative prediction of velocity and pressure fluctuations in turbulent flows around such bluff bodies have been evolving over the years. The main aim of the present work is to investigate experimentally and numerically the flow field in the wake region of different bluff bodies such as circular, square and triangle cross section cylinders placed horizontally perpendicular to the uniform flow. The experimental studies were performed by Particle Image Velocimetry (PIV) method in an open water channel at Reynolds numbers 5000 and 10000 defined according to the characteristic lengths of the cylinders in the facilities of Selcuk University of Advanced Technology Research and Application Center in Turkey. The experimental results are compared to the numerical results obtained by means of transient simulation with LES turbulence model of ANSYS-Fluent Software. It is shown that the numerical and experimental results have a good agreement in respect of the instantaneous and time-averaged flow field patterns of vorticity, velocity component streamwise direction and streamline topology. In addition, drag coefficient of the geometries were also numerically calculated. For all geometries the wake length in x and y directions and size of the foci of the streamlines are decreasing by increasing Reynolds numbers in time-averaged results. The time-averaged flow patterns of both experimental and numerical results have considerable symmetry with respect to the centerline of each cylinder. Contours of the time-averaged stream wise velocity for Re=10000 demonstrate that the stagnation point around the symmetry plane moves further upstream for all cylinders in accordance with Re=5000. The maximum drag coefficient value was yielded for the square cross-section cylinder as 1.78 due to the sharp-edged geometry

The flora of Sülüklü Göl around (Bolu-Adapazarı / Turkey)

Bu çalışma, Sülüklü Göl çevresinin florasının belirlenmesi amacıyla yapılmıştır. Çalışma alanından 2009-2010 yıllarında 579 damarlı bitki örneği toplanmıştır. 79 familyaya [Pteridophyta (4), Pinophytina (3), Magnoliophytina (72)] ve 230 cinse [Pteridophyta (4), Pinophytina (4), Magnoliophytina (222)] ait 406 takson tespit edilmiştir. Toplam 38 takson endemiktir ve endemizim oranı %9,36'dır. Taksonların fitocoğrafik bölgelere göre dağılımı şöyledir; %26,6'sı Avrupa-Sibirya (108 takson), %8,37'si Akdeniz (34 takson), %4,93'ü İranTuran (20 takson) ve %60,1'i çok bölgeli ve bilinmeyen (244 takson) dirThis research was carried out to determine the flora of surrounding of Sülüklü Göl. 579 plant specimens collected from the area, between 2009 and 2010. 406 taxa that belong to 70 families [Pteridophyta (4), Pinophytina (3), Magnoliophytina (72)] and 230 genera [Pteridophyta (4), Pinophytina (4), Magnoliophytina (222)] was determined. The 38 of the total taxa are endemic to Turkey and the rate of endemism is 9,36 %. The phytogeographic elements are represented as follows; Euro-Siberian 26,6 % (108 taxa), Mediterranean 8,37 % (34 taxa), Irano-Turanian 4,93 % (20 taxa) and widespread and others which their regions unclarified 60,1 % (244 taxa