Demulsification of Crude Oil Emulsion in Well X in a Niger Delta Field

Crude oil emulsion is an inevitable phenomenon in hydrocarbon production. Treatment of crude oil emulsion is challenging when the emulsion is stabilized. As crude oil is brought to the surface and pumped to the production facilities, the formation of emulsion increases operating cost. There is a wide array of demulsifiers that are available in the oil and gas industry for the treatment of crude oil emulsion, but one major concern has always been the efficiency of the treatment. No single universal demulsifier can effectively remove emulsion and a combination of two or more is usually expensive. In this study, crude samples were collected from the inlet manifold of a Niger Delta field and bottle tests were conducted with several demulsifiers to select the best chemical demulsifier for use in treating the emulsions as well as the optimum combination. To achieve this objective, twelve different industrial-based demulsifiers were considered which were EXP50, Separol NF-36, Baker-Basf V13-312, Servo CC-8271, Tretolite RP6275, NACCO-Exxon 006-1442, DMO87005, EXP30, AnticorQIT007, AnticorBE027, DMO86634 and DMO81656. It was observed that DMO87005 and AnticorQIT007 produced better results based on separated water volume than other demulsifiers. Hence, the decision to use these demulsifiers to assess their combined potential and the demulsifier factors, namely, concentration, temperature and time effects on the separated water volume using design of experiments (DOE) approach. The results obtained shows that the selected demulsifiers DMO87005 and AnticorQIT007 in a combined form separate more water volume from the crude oil emulsion. Also, the performance of the combined demulsifier is dependent on the combination ratio of the selected demulsifiers. Furthermore, the results depict that the selected (non-combined) demulsifiers and the combined demulsifier factors’ main effects on the separated water volume are concentration, while concentration-time and temperature-time are the factors’ interaction effects for selected and combined demulsifiers, respectively. Again, the magnitude of the main and interaction effects of the combined demulsifier’s factors on the separated water volume is affected by the selected demulsifiers combination ratio. Thus, the combined demulsifier at 0.45mL concentration at a temperature of 90°C for 60 minutes gave a good potential that would necessitate its use for crude oil emulsion treatment in the Niger Delta

Endoparasites of Bucks Raised under Intensive and Semi-Intensive System

An investigation was carried out on bucks in intensive and semi-intensive systems of management. A total of sixteen (16) bucks (male goats) were randomly purchased for the study. The animals were divided into four groups of four animals per treatment and fed Panicum maximum, Gliricidia sepium for Treatment 1 while Treatment 2 were fed Panicum maximum, Gliricidia sepium plus concentrates. Those in T3 were fed concentrate and allowed to graze and T4 were fed Panicum maximum and were also allowed to forage. The result showed significant difference (P<0.05) in infestations of strongyles amongst the treatments

Source Evaluation and Trace Metal Contamination in Benthic Sediments from Equatorial Ecosystems Using Multivariate Statistical Techniques

race metals (Cd, Cr, Cu, Ni and Pb) concentrations in benthic sediments were analyzed through multi-step fractionation scheme to assess the levels and sources of contamination in estuarine, riverine and freshwater ecosystems in Niger Delta (Nigeria). The degree of contamination was assessed using the individual contamination factors (ICF) and global contamination factor (GCF). Multivariate statistical approaches including principal component analysis (PCA), cluster analysis and correlation test were employed to evaluate the interrelationships and associated sources of contamination. The spatial distribution of metal concentrations followed the pattern Pb>Cu>Cr>Cd>Ni. Ecological risk index by ICF showed significant potential mobility and bioavailability for Cu, Cu and Ni. The ICF contamination trend in the benthic sediments at all studied sites was Cu>Cr>Ni>Cd>Pb. The principal component and agglomerative clustering analyses indicate that trace metals contamination in the ecosystems was influenced by multiple pollution sources

Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry.

OBJECTIVE: To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA). METHODS: We analysed the COVID-19 Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD use for RA at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 inhibitors (IL-6i) or tumour necrosis factor inhibitors (TNFi, reference group). The ordinal COVID-19 severity outcome was (1) no hospitalisation, (2) hospitalisation without oxygen, (3) hospitalisation with oxygen/ventilation or (4) death. We used ordinal logistic regression to estimate the OR (odds of being one level higher on the ordinal outcome) for each drug class compared with TNFi, adjusting for potential baseline confounders. RESULTS: Of 2869 people with RA (mean age 56.7 years, 80.8% female) on b/tsDMARD at the onset of COVID-19, there were 237 on ABA, 364 on RTX, 317 on IL-6i, 563 on JAKi and 1388 on TNFi. Overall, 613 (21%) were hospitalised and 157 (5.5%) died. RTX (OR 4.15, 95% CI 3.16 to 5.44) and JAKi (OR 2.06, 95% CI 1.60 to 2.65) were each associated with worse COVID-19 severity compared with TNFi. There were no associations between ABA or IL6i and COVID-19 severity. CONCLUSIONS: People with RA treated with RTX or JAKi had worse COVID-19 severity than those on TNFi. The strong association of RTX and JAKi use with poor COVID-19 outcomes highlights prioritisation of risk mitigation strategies for these people

Evaluation of sesamum gum as an excipient in matrix tablets

In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated