EVALUATION OF MERSIN PROVINCE TOURISM POTENTIAL BY CONTENT ANALYSIS

The aim of this research is to offer suggestions for the work to be done regarding the development of the situation and potential of Mersin tourism. In this context, the opinions about the works that can be done for the current situation and development of Mersin tourism were asked and evaluated by 8 people, including public institution directors, academicians and private sector employees. In this study, semi-structured interview technique that is one of the qualitative research methods was used. In our study, the interview form prepared as a data collection tool has been revealed due to the opinions of the experts about the subject. As a result, the form consists of 8 questions and the first  question that we have prepared determine the demographics features of the participants, while the other 7 questions are related to the feasibility of Mersin tourism regarding the current situation and potential of it. At the end of the study, strengths and weaknesses of Mersin tourism have been revealed. In addition, it is another contribution to the field of the study that reveals potential studies that can be done about Mersin tourism. It is believed that  as a result of this study, the thoughts and suggestions have been revealed will be  light and guide to other studies to be done in the field.  Article visualizations

New Space: The European Union's Evolving Space Policy and Changing European Space Ecosystem

Throughout the years, the identity and institutional capacity of the European Union (EU) has changed. As a global actor in international politics, the EU has perceived the need for developing a comprehensive space policy perspective. This perspective has evolved by the changing dynamics of the space ecosystem i.e., "New Space", and it is a phenomenon that consists of new business models, new technologies, new markets, new value chains, and new actors. New actors in space activities have drastically altered the dynamics of space activities. This paper aims to examine the new actors in the context of European space governance, and scrutinise the tendencies of space companies so as to develop a better understanding of the European space system. The article concludes that, being aware of the undeniable importance of space applications and the security of space systems, the EU attaches importance to catching the "New Space" trend in its governance structure and encouraging appropriate changes in the sector

Poliolefin modifiye bitümün Marshall stabilitesi üzerindeki etkisi

It is possible to improve the performance of the hot mix asphalt (HMA) by improving the properties of the materials (aggregate, bitumen) used in the HMA or by the addition of some special materials. In this study; polypropylene (PP) and high density polyethylene (HDPE) waste plastics were co–pyrolyzed at a temperature range of 300–350 °C. 2, 4, 5 and 6 % modified bitumen were made by using the solid product (char–additive) obtained from co–pyrolysis and pure 50/70 penetration grade bitumen. RV (rotational viscometer) tests were applied to pure and modified bitumens at different temperatures (60–165 °C) and the optimum rate of PP–HDPE additive was determined to be 5 %. Then; two different HMA sample series were prepared with Marshall apparatus using pure and 5 % PP–HDPE modified bitumen. For Marshall Mix design, sample series were formed at bitumen rates 3.5; 4; 4.5; 5 and 5.5 % and four HMA samples were produced at each bitumen rate. The samples were weighed in water, dry and saturated surface–dry. The heights of the samples were measured and the Marshall stability and flow values were determined by applying a load at a certain speed (50 mm/min). As a result; compared to the pure HMA, it was observed that the Marshall stability of the modified HMA increases between about 8.5 and 13 %.Bitümlü sıcak karışımda (BSK) kullanılan malzemelerin (agrega, bitüm) özelliklerini iyileştirerek veya bazı özel malzemeler ilave ederek, BSK’nın performansını artırmak mümkündür. Bu çalışmada; polipropilen (PP) ve yüksek yoğunluklu polietilen (YYPE) atık plastikleri 300–350 °C sıcaklık aralığında birlikte piroliz edildi. Pirolizden elde edilen katı ürün (çar–katkı maddesi) ve saf 50/70 penetrasyon dereceli bitüm kullanılarak, % 2, 4, 5 ve 6 oranlarında modifiye bitümler yapıldı. Saf ve modifiye bitümlere, farklı sıcaklıklarda (60–165 °C) RV (dönel viskozimetre) testleri uygulandı ve PP–YYPE katkısının optimum oranı % 5 olarak belirlendi. Sonra; saf ve % 5 PP–YYPE modifiye bitüm kullanılarak, Marshall aparatı ile iki farklı BSK numune serisi hazırlandı. Marshall karışım tasarımı için, % 3,5; 4,0; 4,5; 5,0 ve 5,5 bitüm oranlarında numune serileri oluşturuldu ve her bir bitüm oranında 4 BSK numunesi üretildi. Kuru ve doygun yüzey–kuru olarak tartılan numuneler, su içinde tartıldı. Numunelerin yükseklikleri ölçüldü ve belirli bir hızda (50 mm/dakika) bir yük uygulanarak, Marshall stabilite ve akma değerleri belirlendi. Sonuç olarak; saf BSK ile karşılaştırıldığında, modifiye BSK'nın Marshall stabilitesinin yaklaşık % 8,5 ila 13,0 arasında arttığı gözlenmiştir

Does non-steroidal anti-inflammatory drugs increase tumor necrosis factor-alpha levels?

Background: The study was designed to investigate the possible effects of the non-steroidal anti-inflammatory drugs on the levels of TNF-alpha in osteoarthritis patients.  Methods: Three different non-steroidal anti-inflammatory drug; diclofenac sodium (100 mg), indomethacin (25 mg) and nabumethon (500 mg) have been included to the study. Twenty osteoarthritis patients who do not have another inflammatory disease for each group of NSAID were recruited from outpatients’ clinics of our hospital. Blood samples of these patients were collected before (at 0 hour) and after (at first and sixth hours) one of these NSAIDs was given orally for the sequential measurements of the serum levels of TNF-α.Results: In all groups, levels of TNF-alpha were similar at the beginning of the study before the placebo and drugs. One hour later, after the NSAIDs were given, increased levels of TNF-alpha were obtained in diclophenac and nabumethone (55.4 ± 52.4 and 35.7 ± 27.9) groups. In contrast to diclofenac group, increased levels of TNF-alpha was insignificant in nabumethone group (P>0.05). However, at six hours later after drugs have been given, TNF-alpha levels decreased to basic levels at the beginning in only nabumethone group. Levels of the TNF-alpha in diclofenac group (101.9 ± 142.2) increased significantly at sixth hour, too. In contrast to this result, insignificant increase has been found in indomethacin and nabumethone groups (39.6 ± 34.6 and 30.2 ± 15.9). No significant changes were obtained in control group.Conclusions: This study shows that levels of TNF-alpha may increase after NSAIDs have been taken orally. NSAIDs effects in our study, increasing TNF-alpha levels may cause unexpected results and may also alter the inflammation.  

Locally controlled MOF growth on functionalized carbon nanotubes

Metal-organic frameworks (MOFs) are highly versatile materials because of their tunable properties. However, the typically poor electrical conductivity of MOFs presents challenges for their integration into electrical devices. By adding carbon nanotubes to MOF synthesis, a highly intergrown material with increased conductivity and chemiresistive sensing properties can be obtained. Here, we present a patterning technique to control MOF growth on predefined areas of one particular carbon nanotube. We found that electron beam pretreatment of -COOH functionalized multi-walled carbon nanotubes inhibits the growth of UiO-66 MOF on these multi-walled carbon nanotubes. By irradiating individual multi-walled carbon nanotubes, we show that MOF growth can be inhibited in predefined tube areas, creating MOF-free spaces on the nanotube. In this way, our method shows a possibility to pattern MOF growth on individual nanotubes

The Effect of Ag Content of the Chitosan-Silver Nanoparticle Composite Material on the Structure and Antibacterial Activity

The aim of this study is to investigate the antibacterial properties and characterization of chitosan-silver nanoparticle composite materials. Chitosan-silver nanoparticle composite material was synthesized by adding AgNO3 and NaOH solutions to chitosan solution at 95°C. Different concentrations (0,02 M, 0,04 M, and 0,06 M) of AgNO3 were used for synthesis. Chitosan-silver nanoparticle composite materials were characterized by Transmission electron microscopy (TEM), X-ray diffraction (XRD), ultraviolet (UV) spectrophotometer, and Fourier transform infrared (FTIR) spectrometer techniques. Escherichia coli, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Streptococcus pneumoniae were used to test the bactericidal efficiency of synthesized chitosan-Ag nanoparticle composite materials. The biological activity was determined by the minimum bacterial concentration (MBC) of the materials. Antibacterial effect of chitosan-silver nanoparticle materials was increased by increasing Ag amount of the composite materials. The presence of small amount of metal nanoparticles in the composite was enough to significantly enhance antibacterial activity as compared with pure chitosan

Gesundheitspolitik, Wettbewerb und Gesundheitssystemforschung

In dem vorliegenden dritten Band der Reihe „DIBOGS-Beiträge zur Gesundheitsökonomie und Sozialpolitik“ wird ein breites Spektrum an gesundheitsökonomischen und gesundheitspolitischen Themen diskutiert und der Öffentlichkeit vorgestellt. Die Beiträge sollen tiefer gehende fachwissenschaftliche Veröffentlichungen an anderer Stelle nicht ersetzen, sondern vielmehr auf diese „Appetit machen“ und inhaltlich Hilfestellung für weitere, umsetzungsbezogene Aufgaben geben. Der Schwerpunkt liegt auf den theoretischen und ökonometrischen Ergebnissen der aktuellen Gesundheitsforschung. Die Überlegungen analysieren zentral den bestehenden Ordnungsrahmen in Deutschland und beleuchten neue Trends und Entwicklungen in Deutschland sowie in Gesundheitssystemen weltweit.Weitere Autoren: Stephen Morris, Andreas Schmid, Leonie Sundmacher, Torsten Steinrücken, Nadine Wiese und Jürgen Zert

Isolated thumb carpometacarpal joint dislocation: a case report and review of the literature

<p>Abstract</p> <p>Background</p> <p>Isolated thumb carpometacarpal dislocation is a rare injury pattern and the optimal treatment option is still controversial.</p> <p>Case Description</p> <p>We present a 27-year-old basketball player who underwent an isolated dorsal dislocation of the thumb carpometacarpal joint after a fall. The dislocation was successfully reduced by closed means but the joint was found to be grossly unstable. Due to inherent instability, repair of the ruptured dorsoradial ligament and joint capsule was performed.</p> <p>The ligament was detached from its proximal insertion into trapezium and subsequently stabilized via suture anchors. The torn capsule was repaired in an end-to-end fashion and immobilization of the joint was applied for 6 weeks.</p> <p>Results</p> <p>At 3-year follow up evaluation the patient was pain free and returned to his previous level of activity. No restriction of carpometacrpal movements or residual instability was noticed. Radiographic examination showed normal joint alignment and no signs of subluxation or early osteoarthritis.</p> <p>Conclusion</p> <p>Surgical stabilization of the dorsal capsuloligamentous complex may be considered the selected treatment option in isolated carpometacarpal joint dislocations, that remain unstable after closed reduction in young and high demand patients.</p> <p><b>Level of Clinical Evidence: </b>Level IV</p