THE EFFECT OF 12 WEEKS CIRCUIT-TRAINING ON HEEL CONTACT VELOCITY AND REACTION TIME IN ELDERLY WOMEN

The purpose of this study was to determine the effects of circuit-training on heel contact velocity (HCV) during walking and reaction time (RT) in community-dwelling elderly women. Subjects were 20 healthy independent elderly women who participated in circuittraining which consisted of posture control, strength training and walking training for 12 weeks. Study outcomes included gait test, reaction time test, and 30-s chair stand test. RT and HCV were decreased significantly. The times of the 30-s chair stand test was increased significantly after training. These findings suggest that 12 weeks of circuittraining may attenuate the risks of slips and slip-initiated falls during walking in community-dwelling elderly women

Effects of 2'-O-(trifluoromethyl)adenosine on oligodeoxynucleotide hybridization and nuclease stability

The synthesis and properties of oligodeoxynucleotides (ODNs) containing 2′-O-(trifluoromethyl)adenosine (2) are described. 2′-O-(Trifluoromethyl)adenosine (2) or N6-(benzoyl)-2′-O-(trifluoromethyl)adenosine (6) was obtained in 22 or 32% yield by treating 2′-O-[(methylthio) thiocarbonyl]-3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane- 1,3-diyl)(TIPDS)adenosine (4) or N6,N6-(dibenzoyl)-2′-O-[(methylthio)thiocarbonyl]-3′,5′-O-(TIPDS)- adenosine (5), respectively, with pyridinium poly-(hydrogen fluoride) in the presence of 1,3-dibromo- 5,5-dimethylhydantoin. Nucleoside 2 was incorporated into DNA hexadecamers. ODNs that contained 2 reduced the thermal stability of duplexes with their complementary DNAs but increased the thermal stability of duplexes with their complementary RNAs. Furthermore, ODNs containing 2 were slightly more resistant to snake venom phosphodiesterase than an unmodified ODN

Bacillus subtilis Bacteremia from Gastrointestinal Perforation after Natto Ingestion, Japan

We report a case of Bacillus subtilis variant natto bacteremia from a gastrointestinal perforation in a patient who ingested natto. Genotypic methods showed the bacteria in a blood sample and the ingested natto were the same strains. Older or immunocompromised patients could be at risk for bacteremia from ingesting natto

Perception of overseas experiences among medical students in Japan: a national online survey

Abstract Background Data on the perceptions of medical students on international experience in non-English-speaking high-income countries (HICs) are very limited. This study aimed to assess the perceptions of medical students in Japan toward overseas experience while in school and post-graduation, as well as to characterize the support they require to pursue their profession in international settings. Methods A cross-sectional national survey was administered online between September 16, 2020, and October 8, 2020. Participants were recruited from 69 medical schools using snowball sampling through acquaintances and social media platforms. The survey results were analyzed by two researchers. Results A total of 548 students from 59 medical schools responded to the survey. Among them, 381 respondents (69%) expressed interest in working abroad, while only 40% seriously considered it. The majority of students responded that they would like to pursue clinical training abroad for a short term or while they were medical students (54%) or during a residency/fellowship (53%). The most popular regions among the respondents for future international experiences were North America and Europe. Finally, the most reported reasons for hesitation to work abroad were language barriers (70%), followed by lack of clarity regarding career options after working abroad (67%), difficulties obtaining medical licensure abroad (62%), and the lack of role models (42%). Conclusions Although nearly 70% of participants reported a high interest in working overseas, various barriers to working abroad were identified. Our findings identified key problem areas that could be targeted when promoting international experiences for medical students in Japan