Mathematical Analysis of Spread and Control of Diphtheria with Emphasis on Diphtheria Antitoxin Efficiency

Diphtheria, a bacterial infection caused by Corynebacterium diphtheriae, remains a significant public health concern worldwide. In this study, we employ mathematical modeling to analyze the spread and control of diphtheria, focusing on the efficacy of Diphtheria Antitoxin in mitigating the disease's impact. Through the development of compartmental models, system of differential equations governing the dynamics was formulated. Due to the complexity and non-linearity of the dynamics, a numerical solutions that utilizes Runge-Kutta Fehlberg order 4 and 5 method. The dynamics of diphtheria transmission and the potential impact of DAT administration on disease outcomes was investigate. Our findings highlight the critical role of Antitoxin efficiency in reducing disease burden, preventing severe cases, and containing epidemic spread. By exploring various scenarios and parameter sensitivities, we provide insights into optimal control strategies and intervention measures to combat diphtheria outbreaks effectively. This research contributes to a better understanding of diphtheria epidemiology and informs public health policies aimed at enhancing vaccination coverage and DAT availability to achieve sustainable disease control and prevention.&nbsp

Analysis of Sustainable Cassava Biofuel Production in Nigeria

Nigeria's biofuels policy advocates the adoption of cassava as feedstock for a 10%-biofuel substitution option in Nigerian transport fuel demand. This policy option is expected to address energy security and environmental consequences of using fossil fuels as the sole source of transport energy in the country. This paper appraised the technological and economic factors necessary for achieving Nigeria's cassava-based biofuel initiative at different substitution levels of 5, 10, and 15% by the Year 2020. A multi-stage energy forecasting and project analysis framework adapted from Coate's structure for technology assessment, as well as engineering economy methodology was used for the study. Technological analysis entailed determining petrol consumption projection, R&D capability, input feedstock requirements, environmental considerations and land requirement for feedstock crop production while engineering economy analysis evaluated the economic viability of the project. The results showed that petrol consumption in Nigeria and bioethanol substitution requirements were in the range of 18,285.7 – 19,142.84 thousand tons and 914.28 (5% low demand) – 2871.43 (15% high demand) thousand tons, respectively by 2020. Cassava feedstock and landmass requirements for bioethanol production were in the range of 4.64 – 14.53 million tons and 4.08 – 12.80 thousand sq. km, respectively while carbon dioxide savings were between 1.87 – 5.89 million tons by 2020. The recovery price for cassava bioethanol was estimated to be US$ 0.74/litre . Petrol being subsidised presently is harmful to the environment though it ‘oils’ the economy. Nigeria currently subsidizes petroleum products to the tune of 28% of 2011 budget. The government plans to remove this by 2012. Thus we conclude that weighing both economic and environmental benefits of bioethanol substitution in petrol consumption in Nigeria, the study showed that bioethanol production from cassava feedstock would be both technically and economically viable, provided subsidy, which depends on political will on the side of the government, is introduced for the first ten years of its implementation

Effect of subclinical, clinical and supraclinical doses of calcium channel blockers on models of drug-induced hepatotoxicity in rats

Drug-related hepatotoxicity is the leading cause of acute liver failure, and hepatic problems are responsible for a significant number of liver transplantations and deaths worldwide. Calcium has been associated with various metabolic processes that lead to cell death and apoptosis, and increased cytosolic Ca2+ has been implicated in hepatotoxicity. This study was designed to investigate the effects of calcium channel blockers (CCBs) on isoniazid-rifampicin, zidovudine and erythromycin-induced hepatotoxicity in rats. Treatment groups comprised control, hepatotoxicant, hepatotoxicant along with each of silymarin, nifedipine, verapamil and diltiazem at subclinical, clinical and supraclinical doses. A day to the end of treatment for each model, rats were subjected to the hexobarbitone-induced hypnosis test. On the last days of treatment, blood samples were collected and serum was analyzed for relevant biochemical parameters. Animals were sacrificed after blood collection and livers were harvested, and samples obtained for in vivo antioxidant indices assay and histopathology. The hepatotoxicants significantly increased serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), as well as duration of sleep in the hypnosis test. These drugs significantly reduced the hepatic levels of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and increased the level of malondialdehyde (MDA). The CCBs at the various doses significantly reversed the effects of isoniazid-rifampicin, zidovudine and erythromycin. The results obtained in this study suggest that the CCBs possess hepatoprotective activity in drug-induced hepatotoxicity and may be beneficial at the subclinical and clinical doses

Estimating the prevalence of COPD in an African country:evidence from southern Nigeria

# BACKGROUND: Though several environmental and demographic factors would suggest a high burden of chronic obstructive pulmonary disease (COPD) in most African countries, there is insufficient country-level synthesis to guide public health policy. # METHODS: A systematic search of MEDLINE, EMBASE, Global Health and African Journals Online identified studies reporting the prevalence of COPD in Nigeria. We provided a detailed synthesis of study characteristics, and overall median and interquartile range (IQR) of COPD prevalence in Nigeria by case definitions (spirometry or non-spirometry). # RESULTS: Of 187 potential studies, eight studies (6 spirometry and 2 non-spirometry) including 4,234 Nigerians met the criteria. From spirometry assessment, which is relatively internally consistent, the median prevalence of COPD in Nigeria was 9.2% (interquartile range, IQR: 7.6–10.0), compared to a lower prevalence (5.1%, IQR: 2.2–15.4) from studies based on British Medical Research Council (BMRC) criteria or doctor’s diagnosis. The median prevalence of COPD was almost the same among rural (9.5%, IQR: 7.6–10.3) and urban dwellers (9.0%, IQR: 5.3–9.3) from spirometry studies. # CONCLUSIONS: A limited number of studies on COPD introduces imprecision in prevalence estimates and presents concerns on the level of response available across different parts of Nigeria, and indeed across many countries in sub-Saharan Africa

High Energy Physics Opportunities Using Reactor Antineutrinos

Nuclear reactors are uniquely powerful, abundant, and flavor-pure sources ofantineutrinos that continue to play a vital role in the US neutrino physicsprogram. The US reactor antineutrino physics community is a diverse interestgroup encompassing many detection technologies and many particle physicstopics, including Standard Model and short-baseline oscillations, BSM physicssearches, and reactor flux and spectrum modeling. The community's aims offerstrong complimentary with numerous aspects of the wider US neutrino program andhave direct relevance to most of the topical sub-groups composing the Snowmass2021 Neutrino Frontier. Reactor neutrino experiments also have a directsocietal impact and have become a strong workforce and technology developmentpipeline for DOE National Laboratories and universities. This white paper,prepared as a submission to the Snowmass 2021 community organizing exercise,will survey the state of the reactor antineutrino physics field and summarizethe ways in which current and future reactor antineutrino experiments can playa critical role in advancing the field of particle physics in the next decade.<br

General anaesthetic and airway management practice for obstetric surgery in England: a prospective, multicentre observational study

There are no current descriptions of general anaesthesia characteristics for obstetric surgery, despite recent changes to patient baseline characteristics and airway management guidelines. This analysis of data from the direct reporting of awareness in maternity patients’ (DREAMY) study of accidental awareness during obstetric anaesthesia aimed to describe practice for obstetric general anaesthesia in England and compare with earlier surveys and best-practice recommendations. Consenting patients who received general anaesthesia for obstetric surgery in 72 hospitals from May 2017 to August 2018 were included. Baseline characteristics, airway management, anaesthetic techniques and major complications were collected. Descriptive analysis, binary logistic regression modelling and comparisons with earlier data were conducted. Data were collected from 3117 procedures, including 2554 (81.9%) caesarean deliveries. Thiopental was the induction drug in 1649 (52.9%) patients, compared with propofol in 1419 (45.5%). Suxamethonium was the neuromuscular blocking drug for tracheal intubation in 2631 (86.1%), compared with rocuronium in 367 (11.8%). Difficult tracheal intubation was reported in 1 in 19 (95%CI 1 in 16–22) and failed intubation in 1 in 312 (95%CI 1 in 169–667). Obese patients were over-represented compared with national baselines and associated with difficult, but not failed intubation. There was more evidence of change in practice for induction drugs (increased use of propofol) than neuromuscular blocking drugs (suxamethonium remains the most popular). There was evidence of improvement in practice, with increased monitoring and reversal of neuromuscular blockade (although this remains suboptimal). Despite a high risk of difficult intubation in this population, videolaryngoscopy was rarely used (1.9%)

Organisational Branding, A Strategic Tool for Engineering Customer Satisfaction in Service Industry: A Study of Selected Banks

Effective brand strategies cannot be developed without the customers in mind, hence the need to examine how brand strategies affect the behaviours of these customers to yield a good result. The objective of this study is to evaluate the impact of organisational branding on the levels of customer patronage. A descriptive and survey design was adopted for the study. The population for this study consist of customers from Wema and Zenith bank within Lagos metropolis. The questionnaire was used in eliciting information from respondents, which contained two sections. Two research questions and hypotheses were raised and tested. The data collected was analysed using Statistical Package for Social Sciences (SPSS version 20.0), for frequency distribution. Further analysis was carried out using linear regression and correlation analysis. From the findings made in the study, there is a significant role played by brand identity in meeting customer expectation and there is a significant effect of brand culture on customer satisfaction. It was recommended that management should be conscious of their peculiar corporate identity once established in order to capitalize on their strengths and opportunities, as well as improve on their weaknesses and address their threats in good time and Managers should strive to create a peculiar brand culture in line with their given brand identity, as the creation of a strong brand culture will enable the staff of the organisation to deliver quality service for good customer satisfaction