The 33-year Retrospective Analysis of Esophageal Carcinomas: Cerrahpaşa Experience

Aim:Esophageal cancer is a fatal disease where the majority of patients are diagnosed at an advanced stage. In this study, we aimed to present the demographic and clinicopathological characteristics of patients who were operated for esophageal cancer.Materials and Methods:A total of 847 patients who underwent surgery, chemoradiotherapy, or palliative procedures for esophageal pathology between the years of 1985 and 2018 were retrospectively analyzed. Age, gender, tumor location, histopathology, surgical technique, and chemoradiotherapy history of patients were analyzed.Results:In the study, 488 patients were male (60.5%) and 319 were female (39.5%). The ratio of males and females was 1.52. The average age was 58.6 years, and 80.1% were older than 50 years. The most common pathological material obtained was squamous cell carcinoma (67.5%), followed by adenocarcinoma (27.7%). Total esophagectomy was performed in 435 patients; distal esophagectomy was performed in 38 patients. Transhiatal esophagectomy (n=271, 62.2%) was the most common procedure that was performed.Conclusion:Esophagectomy is the primary treatment modality for esophageal cancers. When determining the optimal treatment, appropriate patient selection, staging, and risk assessment should be made. Patient-specific treatment should be planned with a multidisciplinary approach

A Novel Approach for Horizontal Augmentation of Posterior Maxilla Using Ridge Split Technique

Karan, Nazife Begum/0000-0003-1027-792XWOS: 000480748200103PubMed: 31299774Over the years, there have been a series of innovative approaches to the alveolar bone augmentation techniques. These have led to the modifications of the existing methods and the establishment of more efficient ways to obtain sufficient bone mass that is necessary for the implant procedure. the aim of this paper is to propose a novel augmentation technique, and to investigate its efficacy, particularly during the healing process of the maxillary alveolar bone prior to the implant treatment. During the application of the proposed methodology, first, the ridge-split technique was applied to the posterior maxilla. Then, a horizontal augmentation procedure was performed with an autogenous bone graft. Implants were placed at the second month of the surgery. Prosthetic rehabilitation was completed after the osseointegration of the implants. the technique was compared with the ridge-split method with simultaneous implant placement in 14 patients. the groups were divided into 2, the control group and the experimental group, each containing 7 patients. the aimed success criteria for the status of the endosteal implants were fulfilled and there were not any complications observed in the second year of follow-up. the basic practical innovation offered by the proposed surgical technique is to achieve the required horizontal dimension and to change the quality of the bone conveniently. the press-fit insertion leads to multipoint contact healing of the transported bone and the use of cortical block bone in posterior maxilla, led to a significantly advantageous higher stability level for both the placement and the survival of the implants

The Effect of Genistein on Anastomotic Healing in Intestinal Ischemia/Reperfusion Injury

Introduction: Genistein is a natural isoflavonoid and has several pharmacological effects, such as antioxidant, antitumor activity, and improvement of glucose metabolism. The safety of intestinal anastomosis after ischemia-reperfusion (I/R) injury is a critical issue for surgeons. This experimental study aimed to investigate the effects of genistein on anastomotic healing after intestinal I/R injury. Methods: A total of 36 male Wistar Albino rats were divided into four groups: control, I/R, genistein, and genistein + I/R. The control group received segmental ileal resection and ileoileal anastomosis. The I/R group received resection + anastomosis after intestinal I/R. The genistein group was administered subcutaneous injection of 1 mg/kg genistein 12 h and 1 h before the procedure and received ileal resection + anastomosis. The genistein + I/R group received I/R + ileal resection + anastomosis after genistein injection. Anastomotic bursting pressure, hydroxyproline, superoxide dismutase, and glutathione peroxidase levels and histopathological wound healing scores of all rats were measured on post-operative day 5. Results: The anastomotic bursting pressure was significantly higher in the genistein and genistein + I/R groups (P < 0.001). Genistein increased the hydroxyproline concentration and the superoxide dismutase and glutathione peroxidase levels in the intestinal anastomosis (P < 0.001). In histopathological assessment, the mean wound healing score was significantly higher in the genistein group than in the other groups (P < 0.001). Conclusions: Genistein, with its anti-inflammatory and antioxidant properties, shows protective effects against increased oxidative stress after intestinal I/R injury and contributes positively to intestinal anastomotic healing. (c) 2022 Elsevier Inc. All rights reserved

Critical phenomena in dynamical Ising-typed thin films by effective-field theory

The stationary state solutions of the Ising-typed thin films with different layers in the presence of an external oscillatory field are examined within the effective-field theory. The study focuses on the effects of external field frequency and amplitude on the overall behavior. Particular attention is paid on evolution of the special point with dynamic field frequency corresponding to critical temperature of the three-dimensional infinite bulk system where the surface and modified exchange parameters are of no importance. Some findings such as surface enhancement phenomenon and effect of thickness on the dynamic process are introduced together with some other well known characteristics. An attempt is made to explain the relations between the competing time scales (intrinsic microscopic relaxation time of the system and the time period of the external oscillatory field) and frequency dispersion of the critical temperature coordinate of the special point. (C) 2014 Elsevier B.V. All rights reserved

Incidental lesions in appendectomy specimens: Rare or rarely sampled?

OBJECTIVE: During the microscopic examination of the specimens after appendectomy operations performed due to acute appendicitis, pathologists may encounter some incidental and unusual lesions. Appendectomy specimens are sampled as 3 sections/1 paraffin block in many centers. In this study, we aimed to evaluate whether multiple and dense sampling of appendix specimens has an impact on the incidence of incidental lesions of the appendix

Mini-incision open appendectomy versus laparoscopic appendectomy: An experience in a rural hospital

BACKGROUND: There is still no consensus about whether laparoscopic appendectomy should be performed in selected cases or routinely in all cases for treatment of acute appendicitis. Especially for rural hospitals with laparoscopic equipment shortages, it is critical to develop surgical methods alternative to LA. This prospective study aimed to compare mini-incision open appendectomy (MOA) and laparoscopic appendectomy (LA) procedures

Hyalinizing trabecular tumor of the thyroid gland

Hyalinizing trabecular tumor was first described by Carney et al. (1) in 1987 and is a rare benign tumor of the thyroid gland that shares some of the microscopic features of medullary and papillary thyroid carcinoma. Hyalinizing trabecular tumor derives from follicular cells, and it is characterized by an apparent trabecular pattern and intratrabecular hyalinization. In this study, we present the case of a 40-year-old female patient with thyroid gland nodules, whose ultrasound results, clinical behavior, and fine-needle aspiration biopsy results were suspicious; the pathology after thyroidectomy indicated hyalinizing trabecular tumor. We aimed to show the role of clinical behavior, radiology, fine-needle aspiration, and histological and immunohistochemical analysis in the differential diagnosis of hyalinizing trabecular tumor. Hyalinizing trabecular tumor which can be confused with papillary and medullar carcinoma of the thyroid gland, is mostly benign but some malignant and metastatic cases have been reported. Therefore, diagnosis, treatment, and follow-up steps of Hyalinizing trabecular tumor should be planned in consideration of a malignant potential

Renal Vascular and Ureteral Anatomic Variations in 1859 Potential Living Renal Donors

Background. Renal vascular and ureteral anomalies detected by preoperative computed tomography angiography (CTA) are important for determining the side of the donor nephrec-tomy and the optimal surgical technique. In the present study, we aimed to examine the renal vas-cular and ureteral variations in living kidney donor candidates

Laparoscopic mini-gastric bypass versus laparoscopic sleeve gastrectomy in metabolic surgery A single center experience

AIM: The safety and effectiveness of MGB versus LSG remain unclear. In this study, we It has been shown by many clinical studies that laparoscopic sleeve gastrectomy (LSG) and mini-gastric bypass (MGB), two current methods in meta-bolic surgery, may be alternatives to Roux-en-Y gastric aimed to compare the postoperative outcomes of MGB and LSG procedures performed in bariatric surgery.MATERIAL METHODS: A total of 175 patients who underwent MGB and LSG surgery between 2016 and 2018 at a single metabolic surgery center were analyzed retrospectively. Two surgical procedures were compared in terms of the peri-operative, early and late postoperative outcomes.RESULTS: There were 121 patients in the MGB group and 54 patients in the LSG group. No significant difference was found between the groups regarding the operating time, the conversion to open surgery and the early postoperative com-plications (p>0.05). The length of hospital stay was significantly shorter in the MGB group (p:0.001). The excess weight loss (EWL%) and total weight loss (TWL%) were significantly higher in the MGB group (90.3 vs. 79.2; and 36.4 vs 30.5, respectively). No significant difference was found between the two groups in terms of the remission rates of comor-bidities. The symptoms of gastroesophageal reflux were observed in a significantly fewer number of the patients in the MGB group (6 patients 4.9% vs. 10 patients 18.5%).CONCLUSIONS: Both LSG and MGB are effective, reliable, and useful methods in metabolic surgery. The MGB proce-dure is superior to the LSG in terms of the length of hospital stay, EWL%, TWL% and the postoperative gastroe-sophageal reflux symptoms