Laboratory Diagnosis and Management of von Willebrand Disease in Turkey: Izmir Experience

WOS: 000295698300022PubMed ID: 22102203von Willebrand disease (VWD) is caused by a deficiency or dysfunction of von Willebrand factor (VWF). The pathophysiology, classification, diagnosis, and management of VWD are relatively complex, but their understanding is important for proper diagnosis and management of patients with VWD. There are inherent difficulties in both the identification and classification of VWD because of clinical uncertainty and the limitations in the test processes and test panels typically used by laboratories. The most common test panel employed by laboratories, particularly in the geographic regions covered by the mutational studies, would comprise factor VIII coagulant (FVIII:C), VWF protein (antigen; VWF:Ag), and ristocetin cofactor (VWF:RCo). In our center, use of a desmopressin challenge with our core four-test panel (i.e., VWF:Ag, VWF:RCo, FVIII:C, and PFA-100) is expected to further assist laboratory diagnosis of VWD in Turkey. Molecular genetics is a rather new approach for Turkey, with gene analyses related to VWD being initiated in one center and the results used for confirmation of diagnosis in limited cases

Effect of different crown removing procedures on the implant stability quotient and removal torque values of dental implants

Objective: To investigate the effects of different crown-removal methods on the osseointegration of dental implants in implant-retained single crowns

Java-based Program to Study User Choice Behavior for Alternate Routes

This paper present learning stochastic automata as a model for traveller route choice. The theoretical aspects of the model are discussed. A JAVA based program was developed to acquire data from subjects, which are being used to validate the models

Effect of Different Crown Removing Procedures on the Implant Stability Quotient and Removal Torque Values of Dental Implants

Objective: To investigate the effects of different crown-removal methods on the osseointegration of dental implants in implant-retained single crowns