5,315 research outputs found
Fluctuations of Complex Networks: Electrical Properties of Single Protein Nanodevices
We present for the first time a complex network approach to the study of the
electrical properties of single protein devices. In particular, we consider an
electronic nanobiosensor based on a G-protein coupled receptor. By adopting a
coarse grain description, the protein is modeled as a complex network of
elementary impedances. The positions of the alpha-carbon atoms of each amino
acid are taken as the nodes of the network. The amino acids are assumed to
interact electrically among them. Consequently, a link is drawn between any
pair of nodes neighboring in space within a given distance and an elementary
impedance is associated with each link. The value of this impedance can be
related to the physical and chemical properties of the amino acid pair and to
their relative distance. Accordingly, the conformational changes of the
receptor induced by the capture of the ligand, are translated into a variation
of its electrical properties. Stochastic fluctuations in the value of the
elementary impedances of the network, which mimic different physical effects,
have also been considered. Preliminary results concerning the impedance
spectrum of the network and its fluctuations are presented and discussed for
different values of the model parameters.Comment: 16 Pages and 10 Figures published in SPIE Proceedings of the II
International Symposium on Fluctuation and Noise, Maspalomas,Gran
Canaria,Spain, 25-28 May 200
Modelization of Thermal Fluctuations in G Protein-Coupled Receptors
We simulate the electrical properties of a device realized by a G protein
coupled receptor (GPCR), embedded in its membrane and in contact with two
metallic electrodes through which an external voltage is applied. To this
purpose, recently, we have proposed a model based on a coarse graining
description, which describes the protein as a network of elementary impedances.
The network is built from the knowledge of the positions of the C-alpha atoms
of the amino acids, which represent the nodes of the network. Since the
elementary impedances are taken depending of the inter-nodes distance, the
conformational change of the receptor induced by the capture of the ligand
results in a variation of the network impedance. On the other hand, the
fluctuations of the atomic positions due to thermal motion imply an impedance
noise, whose level is crucial to the purpose of an electrical detection of the
ligand capture by the GPCR. Here, in particular, we address this issue by
presenting a computational study of the impedance noise due to thermal
fluctuations of the atomic positions within a rhodopsin molecule. In our model,
the C-alpha atoms are treated as independent, isotropic, harmonic oscillators,
with amplitude depending on the temperature and on the position within the
protein (alpha-helix or loop). The relative fluctuation of the impedance is
then calculated for different temperatures.Comment: 5 pages, 2 figures, Proceeding of the 18-th International Conference
on Fluctuations and Noise, 19-23 September 2005, Salamanca, Spain -minor
proofreadings
The gamma-ray telescope Gamma-1
French and Soviet specialists have designed and built the gamma-ray telescope GAMMA-1 to detect cosmic gamma rays above 50 MeV. The sensitive area of the detector is 1400 sq cm, energy resolution is 30% at 300 MeV, and angular resolution 1.2 deg at 300 MeV (and less than 20' arc when a coded aperture mask is used). Results on calibration of the qualification model and Monte-Carlo calculations are presented
Observation of non-local dielectric relaxation in glycerol
Since its introduction, liquid viscosity and relaxation time have been
considered to be an intrinsic property of the system that is essentially local
in nature and therefore independent of system size. We perform dielectric
relaxation experiments in glycerol, and find that this is the case at high
temperature only. At low temperature, increases with system size and
becomes non-local. We discuss the origin of this effect in a picture based on
liquid elasticity length, the length over which local relaxation events in a
liquid interact via induced elastic waves, and find good agreement between
experiment and theory
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