Comparative Analgesic and Anti-inflammatory Activities of Two Polyherbal Tablet Formulations (Aujaie and Surangeen) in Rats

Purpose: To investigate the analgesic and anti-inflammatory activities of two herbal polymedicines - Aujaie and Surangeen to ascertain their therapeutic claims.Methods: A total of 96 rats were divided into two equal groups; one for determination of antiinflammatory activity and the other for analgesic activity. Anti-inflammatory and analgesic activities were evaluated by carrageenan-induced paw edema and formalin-induced paw licking test, respectively. For both studies, group I (untreated control) received 1 ml/kg, (po) of gum suspension 1 h before carrageenan injection. Aspirin (100 mg/kg, po) was given to group II (treated control) before injection. Groups III, IV and V were administered orally aujaie (3, 4 and 5 mg/kg, po, respectively), while surangeen tablets (10, 20 and 40 mg/kg, po) were given to groups VI, VII and VIII, respectively. Pain was experimentally induced by injecting 0.1 ml of 2.5 % formalin (40 % formaldehyde in distilled water) via the subplantar region of the left hind paw.Results: Significant (p < 0.05) anti-inflammatory activity for aspirin (group II as well as for groups III - VIII with paw edema inhibition (PDI) ranging from 24.6 - 90.2 %, There was significant ((p < 0.05) analgesic activity in group II, VI and VII while in groups III - V and VIII the activity was insignificant (p < 0.05).Conclusion: Aujaie and surangeen tablets exhibited pronounced analgesic and anti-inflammatory activities in rats depending on the dose employed.Keywords: Aujaie, Surangeen, Anti-inflammatory, Analgesic

Factors Influencing Career Routes of Female Librarianship: A Literature Review

This research paper aims to understand elements that act as counter-productive to the achievements of females working as professional librarians. The paper uses current literature to explore inhibitive factors for the career development of female librarians. The methodology employed in the paper is epistemological realism and deductive reasoning. This methodology adds to existing knowledge while being linked with realism. The research investigates main factors like cultural stereotyping, discrimination against women, marriage, children, career breaks, mentoring, family support, and organizational structure and policies to ascertain their role in enhancing or diminishing female librarians’ career progression. The nature of research is deductive as the conclusions are drawn from available literature as applied to professional females in the field of librarianship. The findings of the research are expected to validate these important factors as integral stimulants for female librarians’ career development

Proximate composition and mineral profile of eight different unstudied date (Phoenix dactylifera L.) varieties from Pakistan

With the aim of extending the knowledge on chemical composition of dates (Phoenix dactylifera L.), eight different sun dried date varieties; (1) Daki, (2) Aseel, (3) Coconut, (4) Khuzravi, (5) Halavi, (6) Zahidi, (7) Deglet Noor and (8) Barkavi were examined to determine their proximate composition and mineral profile. All the date varieties were found to be rich in proteins, fiber, carbohydrates and net gross energy (352.329 Kcal/100 g in Aseel to 425.147 Kcal/100 g in Khuzravi) having suitable levels of lipids and low values of ash, moisture and oxalates. Na, K and Li were found as macrominerals whereas Cr, Cu, Ca, Mg, Ni, Zn and Mn were found as microminerals. The results suggest that all the studied dates serve as good source of vital nutrients and can be considered as premium quality having significantly higher energy values than the earlier reported values for dates

Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents

A compound herbal formulation (POL4) has been used in the indigenous system of medicine to treat cardiometabolic disorders like diabetes and associated hypertension. POL4 and most of its constituents have not been studied widely for its therapeutic use in hypertension. This study is aimed to determine the efficacy and possible insight into mechanism(s) for the medicinal use of POL4 and its ingredients in hypertension

Designing a Cloud Analytics Service Framework for Mobile Advertisement and Marketing: A Review

If we talk about data earlier, it was not much larger and complicated because earlier the use of internet and technologies were not in use as it is in current days. Nowadays large amount of data is generated in every second, that’s why Cloud environment became very challenging because of its popularity with the communication, networking and storage theorizes [5]. Today our modern era is significantly dependent on Internet and Mobile applications. Today’s generation prefer to communicate with each other virtually rather than meeting with each other face to face so they use many mobile application or online application for communication using internet and technologies. Survey statics shows that mobile advertisement is rapidly growing that majorly focuses on marketing. In this paper we have surveyed different scenarios of mobile advertisement and marketing that how different methods, algorithm and approaches is being used for mobile advertisement and marketing

Parametric Models For Helicopter Identification Using ANN

An artificial neural network (ANN) based helicopter identification system is proposed. The feature vectors are based on both the tonal and the broadband spectrum of the helicopter signal. ANN pattern classifiers are trained using various parametric spectral representation techniques. Specifically, linear prediction, reflection coefficients, cepstrum, and line spectral frequencies (LSF) are compared in terms of recognition accuracy and robustness against additive noise. Finally, an 8-helicopter ANN classifier is evaluated, It is also shown that the classifier performance is dramatically improved if it is trained using both clean data and data corrupted with additive noise

Parametric Models For Helicopter Identification Using ANN

An artificial neural network (ANN) based helicopter identification system is proposed. The feature vectors are based on both the tonal and the broadband spectrum of the helicopter signal. ANN pattern classifiers are trained using various parametric spectral representation techniques. Specifically, linear prediction, reflection coefficients, cepstrum, and line spectral frequencies (LSF) are compared in terms of recognition accuracy and robustness against additive noise. Finally, an 8-helicopter ANN classifier is evaluated, It is also shown that the classifier performance is dramatically improved if it is trained using both clean data and data corrupted with additive noise

Antihypertensive Activity of Aqueous-Methanol Extract of Berberis Orthobotrys Bien Ex Aitch in Rats

Purpose: To investigate the hypotensive potential of Berberis orthobotrys Bien Ex Aitch (Family: Berberidaceae) in both normotensive and hypertensive rats.Methods: Aqueous-methanol (70:30) extract of Berberis orthobotrys at doses of 25, 50, 75 and 100 mg/kg was evaluated for its effect on blood pressure and heart rate using non-invasive blood pressure measuring apparatus. After initial screening, 100 mg/kg dose that produced a maximum effect was selected for the antihypertensive study. Median lethal dose (LD50) and sub-chronic toxicity of the extract were also determined. Various biochemical parameters and organ weight were measured usingstandard procedures.Results: The extract produced a significant (p < 0.01) decrease in systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP) and heart rate of normotensive rats at all test doses with maximum effect at 100 mg/kg. Similarly, a significant antihypertensive and negative chronotropic effect was observed in both hypertensive models. LD50 of the extract was 200 mg/kg in mice. The extract also exhibited a reduction (p < 0.05) in serum alanine transaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), triglycerides and low density lipoprotein (LDL) levels while a significant (p < 0.05) increase in high density lipoproteins (HDL) level was observed.Conclusion: It seems that the aqueous-methanol extract of Berberis orthobotrys possesses active compounds which may be responsible for the antihypertensive and negative chronotropic effects in rats.Keywords: Berberis orthobotrys, Antihypertensive, Egg feed diet, Blood lipid