Tendencies and prospects of public-private partnership development in the field of physical culture and sport

Attraction of supplementary sources of funding into the sphere of the physical culture and sport (PhCS) is an acute issue in the Russian economy as well as in the countries with higher economic potential. In this connection, the authors of the article consider the public-private partnership (PPP) to be a perspective form of cooperation between the state and the private sector in the aspect of financing of the PhCS development. The article provides the statistic data on the PhCS financing and examines the options of investment return by the private partner that depend on the concrete scheme of the PPP project implementation: further exploitation of the object by the public or the private partner. The authors of the article summarize the foreign experience in the field of support and implementation of the PPP projects in the sports industry and suggest adopting the most effective, tried models of financing, that would allow making comparative evaluation and revision of the current practice of the project financing in Russia, and furthermore would lead to diversification of the services rendered.peer-reviewe

Economic systems sustainable development spatial structures innovatization

© Mikhail Postaliuk, Alsu Akhmetshina, 2014. The article discusses the need for economic systems sustainable development spatial structures innovatization; the paper also presents the characteristic feature of dynamic stability as an ability of an economic system to create and maintain its innovative structure-forming relationships

Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis

Activation of the immune system and increased synthesis of extracellular matrix proteins by fibroblasts are hallmarks in the pathogenesis of SSc. The molecular mechanisms underlying the infiltration of inflammatory cells into the skin and the subsequent activation of fibroblasts are still largely unknown. Chemokines are a family of small molecules that are classified according to the position of the NH2-terminal cysteine motif. Recent data indicate that chemokines and in particular two members of the subfamily of monocyte chemoattractant proteins, MCP-1 (CCL-2) and MCP-3 (CCL-7), might be involved in the pathogenesis of SSc. MCP-1 and -3 are overexpressed by SSc fibroblasts and in skin lesions from SSc patients compared to healthy controls. MCP-1 and -3 are chemotactic for inflammatory cells and stimulate their migration into the skin. In addition to their pro-inflammatory effects, MCP-1 and -3 contribute to tissue fibrosis by activating the synthesis of extracellular matrix proteins in SSc fibroblasts. Therapeutic strategies targeting MCP-1 have revealed promising results in several animal models of SSc. Antagonists against the receptor CCR2 are currently tested in clinical trials of a variety of diseases and also represent interesting candidates for target-directed therapy in SS

Factor analysis of personal consumption in a modern welfare economy

© 2018 Institute of Physics Publishing. All rights reserved. The content and the structure of a personal consumption is an important factor determining the dynamics of economic and social indicators, since consumer expenditure accounts for more than half of total expenditures and determines the amount of investment into the human capital that, in the conditions of a postindustrial society, plays a decisive role in shaping sustainable economic growth rates and realizing a socially oriented national development strategy. The article analyses the peculiarities of the personal consumption process in the conditions of the modern welfare economy and its determinants, there is made an attempt to systematize and identify the interrelations between them, which will help in developing an objective forecast of GDP dynamics, on the basis of which state programs for social and economic development are formed

The institutional aspect of public-private partnership mechanism improvement

The article deals with the problems of public-private partnership (PPP) institutional ystem, the solution of which will contribute to the rationalization of the interaction between government and business, which makes a direct impact on production efficiency improvement and the rate of a country economic growth

Using WRF mesoscale model to restore temperature profile in atmosphere boundary layer in Tomsk

In the paper, the possible use of a WRF mesoscale model for the detailed restoring of a temperature profile in the atmosphere boundary layer (ABL) during winter anticyclone is studied. The correctness of air temperature modeling as well as the possible use of a WRF model for predicting a vertical temperature distribution was show

Follicular Nerve Evoked Responses in the Neonatal Rat Barrel Cortex

© 2016, Springer Science+Business Media New York.In the whisker-related somatosensory system, functional organization of the neuronal circuits is typically assessed through exploration of the responses evoked by whisker deflections. Here, we describe the responses evoked in the neonatal rat barrel cortex by direct electrical stimulation of the follicular nerve and its peripheral branches. Individual whisker follicles and follicular nerves were exposed through a cut on the skin. The electrical stimulation of the follicular nerve and the follicle at different locations using bipolar electrodes reliably evoked responses in the corresponding cortical barrel column. General features of the electrically evoked responses were similar to those evoked by the whisker deflection. However, the delays of the responses evoked by the electrical stimulation were 5-6 ms shorter than those evoked by mechanical whisker stimulation. Also, the magnitude of the follicular nerve evoked responses depended on the stimulation site along the follicle and follicular nerve. We propose that electrical stimulation of a follicular nerve and its branches can be a useful approach to assessing the functional follicle topography

The nature of the sensory input to the neonatal rat barrel cortex

© 2016 the authors.Sensory input plays critical roles in the development of the somatosensory cortex during the neonatal period. This early sensory input may involve: (1) stimulation arising from passive interactions with the mother and littermates and (2) sensory feedback arising from spontaneous infant movements. The relative contributions of these mechanisms under natural conditions remain largely unknown, however. Here, we show that, in the whisker-related barrel cortex of neonatal rats, spontaneous whisker movements and passive stimulation by the littermates cooperate, with comparable efficiency, in driving cortical activity. Both tactile signals arising from the littermate’s movements under conditions simulating the littermates’ position in the litter, and spontaneous whisker movements efficiently triggered bursts of activity in barrel cortex. Yet, whisker movements with touch were more efficient than free movements. Comparison of the various experimental conditions mimicking the natural environment showed that tactile signals arising from the whisker movements with touch and stimulation by the littermates, support: (1) a twofold higher level of cortical activity than in the isolated animal, and (2) a threefold higher level of activity than in the deafferented animal after the infraorbital nerve cut. Together, these results indicate that endogenous (self-generated movements) and exogenous (stimulation by the littermates) mechanisms cooperate in driving cortical activity in newborn rats and point to the importance of the environment in shaping cortical activity during the neonatal period

Immobilization of organic reagents on optically transparent mesoporous polymers and its analytical use

© 2015 Pleiades Publishing, Ltd. Sorption of organic reagents Arsenazo III and 1-(2-pyridylazo)-2-naphthol onto optically transparent mesoporous polymers prepared from macroinitiators and toluene 2,4-diisocyanate was studied. The possibility of preconcentration of organic reagents and their complexation with Cu(II) and Ca(II) ions in the polymer pore voids was demonstrated. Experiments on spectrophotometric analysis using the polymeric support showed that the lower limit of determination was 20 μg mL-1 for Ca(II) and 2 μg mL-1 for Cu(II)