1,404 research outputs found
Ferromagnetic tunneling junctions at low voltages: elastic versus inelastic scattering at
In this paper we analyze different contributions to the magnetoresistance of
magnetic tunneling junctions at low voltages. A substantial fraction of the
resistance drop with voltage can be ascribed to variations of the density of
states and the barrier transmission with the bias. However, we found that the
anomaly observed at zero bias and the magnetoresistance behavior at very small
voltages, point to the contribution of inelastic magnon-assisted tunneling. The
latter is described by a transfer parameter , which is one or two orders
of magnitude smaller than , the direct transmission for elastic
currents. Our theory is in excellent agreement with experimental data, yielding
estimated values of which are of the order of / ~ 40.Comment: 13 pages, 4 figures (in postscript format). PACS numbers: 72.25.-b,
73.23.-b, 72.10.D
Zero Field precession and hysteretic threshold currents in spin torque oscillators with tilted polarizer
Using non-linear system theory and numerical simulations we map out the
static and dynamic phase diagram in zero applied field of a spin torque
oscillator with a tilted polarizer (TP-STO).We find that for sufficiently large
currents, even very small tilt angles (beta>1 degree) will lead to steady free
layer precession in zero field. Within a rather large range of tilt angles, 1
degree< beta <19 degree, we find coexisting static states and hysteretic
switching between these using only current. In a more narrow window (1
degree<beta<5 degree) one of the static states turns into a limit cycle
(precession). The coexistence of static and dynamic states in zero magnetic
field is unique to the tilted polarizer and leads to large hysteresis in the
upper and lower threshold currents for TP-STO operation.Comment: 5 pages, 4 figure
Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo
Neurotransmission during development regulates synaptic maturation in neural circuits, but the contribution of different neurotransmitter systems is unclear. We investigated the role of GABAA receptor-mediated Cl- conductances in the development of synaptic responses in the Xenopus visual system. Intracellular Cl- concentration ([Cl-]i) was found to be high in immature tectal neurons and then falls over a period of several weeks. GABAergic synapses are present at early stages of tectal development and, when activated by optic nerve stimulation or visual stimuli, induce sustained depolarizing Cl- conductances that facilitate retinotectal transmission by NMDA receptors. To test whether depolarizing GABAergic inputs cooperate with NMDA receptors during activity-dependent maturation of glutamatergic synapses, we prematurely reduced [Cl-]i in tectal neurons in vivo by expressing the Cl- transporter KCC2. This blocked the normal developmental increase in AMPA receptor-mediated retinotectal transmission and increased GABAergic synaptic input to tectal neurons. Therefore, depolarizing GABAergic transmission plays a pivotal role in the maturation of excitatory transmission and controls the balance of excitation and inhibition in the developing retinotectal circuit
(E)-2,3-Bis[(E)-benzylideneamino]but-2-enedinitrile
The asymmetric unit of the title compound, C18H12N4, consists of a half-molecule, where the two halves of the molecule are related by inversion symmetry. The molecule is effectively planar, with the largest deviation from the 22-atom mean plane, measuring 0.024 (2) Å, exhibited by the ortho-C atom of the phenyl ring. The crystal structure exhibits π-stacking, with an interplanar spacing of 3.431 (3) Å
Spatial and Temporal Dynamics in the Ionic Driving Force for GABAA Receptors
It is becoming increasingly apparent that the strength of GABAergic synaptic transmission is dynamic. One parameter that can establish differences in the actions of GABAergic synapses is the ionic driving force for the chloride-permeable GABAA receptor (GABAAR). Here we review some of the sophisticated ways in which this ionic driving force can vary within neuronal circuits. This driving force for GABAARs is subject to tight spatial control, with the distribution of Cl− transporter proteins and channels generating regional variation in the strength of GABAAR signalling across a single neuron. GABAAR dynamics can result from short-term changes in their driving force, which involve the temporary accumulation or depletion of intracellular Cl−. In addition, activity-dependent changes in the expression and function of Cl− regulating proteins can result in long-term shifts in the driving force for GABAARs. The multifaceted regulation of the ionic driving force for GABAARs has wide ranging implications for mature brain function, neural circuit development, and disease
In Vivo Spike-Timing-Dependent Plasticity in the Optic Tectum of Xenopus Laevis
Spike-timing-dependent plasticity (STDP) is found in vivo in a variety of systems and species, but the first demonstrations of in vivo STDP were carried out in the optic tectum of Xenopus laevis embryos. Since then, the optic tectum has served as an excellent experimental model for studying STDP in sensory systems, allowing researchers to probe the developmental consequences of this form of synaptic plasticity during early development. In this review, we will describe what is known about the role of STDP in shaping feed-forward and recurrent circuits in the optic tectum with a focus on the functional implications for vision. We will discuss both the similarities and differences between the optic tectum and mammalian sensory systems that are relevant to STDP. Finally, we will highlight the unique properties of the embryonic tectum that make it an important system for researchers who are interested in how STDP contributes to activity-dependent development of sensory computations
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