Review on Nanorobot as a Nanomachine and Biomedicine

Nanorobotics is the technology of producing robots or machines with very small scale or Miniscale of a nanometer (10-9 meters), machines constructed at the molecular level (Nano machines) may Be used to detect or identify and cure the human body of its various diseases like cancer. Nano robots are Very good accuracy they perform a specific task with great accuracy and precision at very small scale or Nanoscale dimension. A recent discovery in the field of drug Delivery is target therapy, which improves the diagnostic tests and Medical devices. Nanotechnology is going to revolutionize the world. According to the National Nanotechnology Initiative (NNI). Nowadays these nano robots play a vital role in the field of Bio Medicine. In the pharma-world, the applications of Nanotechnology mean drugs containing nano-sized active ingredients. They are well used to cure HIV, Cancer, Surgery, Bloodstream, gene therapy, Kidney stone removal and other harmful disease they Can restore lost tissue at the cellular level, useful for monitoring, Diagnosing and fighting sickness. The main purpose is to cure many dreadful Diseases in human body

Review on Therapeutic Uses of Mimosa Pudica (Touch-me-not) Plant

The prostrate or semi-erect subshrub Mimosa pudica L. (Mimosacee), referred to as touch me not, live and die, shame plant, and humble plant, is indigenous to North and South America as well as Australia. They are delicate soft grey green leaves that fold and droop at night or when handled and chilled, and they are thickly equipped with recurved thorns in India. Its peculiar bending behaviors have given it the nickname "curiosity plant." According to Ayurveda, the root of this plant is bitter, acrid, cooling, vulnerary, and alexipharmic. Leprosy, dysentery, vaginal and uterine complaints, inflammations, burning sensations, asthma, leucoderma, tiredness, and blood disorders are among the conditions it is used to treat. It appears to be a prospective herbal candidate deserving of further research, as shown by its pharmacological profile Numerous illnesses, including cancer, diabetes, hepatitis, obesity, and urinary infections, are also prevented or treated using mimosa pudica. It predominantly contains pharmacological activities that include antibacterial, antivenom, antitertility, anticonvulsant, depressant, aphrodisiac, and others. The plant has been used to treat urogenital issues for ages

Review on Calotropis Gigantea as a Topically used Plant

There have been numerous reports of the Asclepiadaceae plant, Calotropis gigantea R.Br, having medicinal and other uses. Plants have been employed as a source of medicinal substances since ancient times. In the indigenous system of medicine, plants are used extensively to treat disease. Traditional medicine makes use of various plant extracts or bioactive substances. This kind of research offers health at a reasonable price. The findings imply that the stem, leaves, and flower's phytochemical qualities can be used to treat a variety of diseases. The nation that produces the most medicinal herbs is India, which is fittingly known as the world's botanical garden. Calotropis gigantea, a member of the Asclepiadaceae/Apocynaceae family, is also referred to as the Crown Flower and has unique therapeutic properties that can be used alone or in conjunction with other medications to treat common disorders. Herbal medicines have a very wide range of medicinal applications. In ayurveda, the entire dried plant is used as a mucus explusor, parasitic worm expeller, and rejuvenator. Leprosy and asthma are treated with its dried root, while vertigo, baldness, hair loss, and rheumatoid arthritis are all treated with its latex. Calotropis is employed for a variety of conventional and homoeopathic treatments. The plant's many parts can be separated and used as medicine to get a variety of benefits

Binding of Gemini Bisbenzimidazole Drugs with Human Telomeric G-Quadruplex Dimers: Effect of the Spacer in the Design of Potent Telomerase Inhibitors

The study of anticancer agents that act via stabilization of telomeric G-quadruplex DNA (G4DNA) is important because such agents often inhibit telomerase activity. Several types of G4DNA binding ligands are known. In these studies, the target structures often involve a single G4 DNA unit formed by short DNA telomeric sequences. However, the 3′-terminal single-stranded human telomeric DNA can form higher-order structures by clustering consecutive quadruplex units (dimers or n-mers). Herein, we present new synthetic gemini (twin) bisbenzimidazole ligands, in which the oligo-oxyethylene spacers join the two bisbenzimidazole units for the recognition of both monomeric and dimeric G4DNA, derived from d(T2AG3)4 and d(T2AG3)8 human telomeric DNA, respectively. The spacer between the two bisbenzimidazoles in the geminis plays a critical role in the G4DNA stability. We report here (i) synthesis of new effective gemini anticancer agents that are selectively more toxic towards the cancer cells than the corresponding normal cells; (ii) formation and characterization of G4DNA dimers in solution as well as computational construction of the dimeric G4DNA structures. The gemini ligands direct the folding of the single-stranded DNA into an unusually stable parallel-stranded G4DNA when it was formed in presence of the ligands in KCl solution and the gemini ligands show spacer length dependent potent telomerase inhibition properties

CURATION AND MANAGEMENT OF CULTURAL HERITAGE THROUGH LIBRARIES

Libraries, museums and archives hold valuable collections in a variety of media, presenting a vast body of knowledge rooted in the history of human civilisation. These form the repository of the wisdom of great works by thinkers of past and the present. The holdings of these institutions are priceless heritage of the mankind as they preserve documents, ideas, and the oral and written records. To value the cultural heritage and to care for it as a treasure bequeathed to us by our ancestors is the major responsibility of libraries. The past records constitute a natural resource and are indispensable to the present generation as well as to the generations to come. Libraries preserve the documentary heritage resources for which they are primarily responsible. Any loss of such materials is simply irreplaceable. Therefore, preserving this intellectual, cultural heritage becomes not only the academic commitment but also the moral responsibility of the librarians/information scientists, who are in charge of these repositories. The high quality of the papers and the discussion represent the thinking and experience of experts in their particular fields. The contributed papers also relate to the methodology used in libraries in Asia to provide access to manuscripts and cultural heritage. The volume discusses best practices in Knowledge preservation and how to collaborate and preserve the culture. The book also deals with manuscript and archives issues in the digital era. The approach of this book is concise, comprehensively, covering all major aspects of preservation and conservation through libraries. The readership of the book is not just limited to library and information science professionals, but also for those involved in conservation, preservation, restoration or other related disciplines. The book will be useful for librarians, archivists and conservators. We thank the Sunan Kalijaga University, Special Libraries Association- Asian Chapter for their trust and their constant support, all the contributors for their submissions, the members of the Local and International Committee for their reviewing effort for making this publication possible

Study of Jaundice profile in Pregnancy in tertiary care centre in central India

Introduction: Pregnancy is complicated by various disorders including jaundice which is an important medical disorder seen more often in developing countries. Jaundice complicates pregnancy, whether of any cause. Jaundice in pregnancy carries a grave prognosis for both the foetus as well as mother. Therefore early detection of cause of jaundice improves the outcome of both. Methods: In present study 50 cases of clinical jaundice with pregnancy in any trimester were selected in the age group of 20 to 35 years over a period of one year. Results: Viral hepatitis was observed in 38 (76%) cases, intrahepatic Cholestasis of pregnancy in 7 (14%) cases, HELLP and hyperemesis gravidarum in 2 (4%) cases each and a single case of drug induced jaundice. Maximum cases of jaundice in pregnancy were observed among the age group between 20 -25 years. Conclusion: Viral hepatitis was seen as the commonest cause of jaundice dominating in all the three trimesters, third trimester having maximum 32 (64%) cases. Therefore monitoring and early diagnosis of jaundice is necessary during pregnancy

Swallowed toothbrush: Case series

Toothbrush swallowing is rare, and most cases are seen in young women with anorexia nervosa or bulimia or associated with mental retardation or schizophrenia. Prompt removal is recommended because no cases of spontaneous passage have been reported. There is no previously reported case series on swallowed toothbrush in mentally normal young men. Here, we report three cases of swallowed toothbrush found in the esophagus and stomach on endoscopy. In our case series, successful removal of the toothbrush was done without endotracheal intubation or over tube, without any complications. To our knowledge, this is the first documented case series of swallowed toothbrush managed successfully endoscopically