8 research outputs found

    Deep Eutectic Solvents (DESs) and their applications [forthcoming]

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    Deep Eutectic Solvents (DESs) and Their Application

    Platelet-rich plasma for managing pain and inflammation in osteoarthritis.

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    Osteoarthritis (OA) is a common disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture. Autologous blood-derived products, such as platelet-rich plasma (PRP), are key sources of molecules involved in tissue repair and regeneration. These products can deliver a collection of bioactive molecules that have important roles in fundamental processes, including inflammation, angiogenesis, cell migration and metabolism in pathological conditions, such as OA. PRP has anti-inflammatory properties through its effects on the canonical nuclear factor κB signalling pathway in multiple cell types including synoviocytes, macrophages and chondrocytes. PRP contains hundreds of different molecules; cells within the joint add to this milieu by secreting additional biologically active molecules in response to PRP. The net results of PRP therapy are varied and can include angiogenesis, the production of local conditions that favour anabolism in the articular cartilage, or the recruitment of repair cells. However, the molecules found in PRP that contribute to angiogenesis and the protection of joint integrity need further clarification. Understanding PRP in molecular terms could help us to exploit its therapeutic potential, and aid the development of novel treatments and tissue-engineering approaches, for the different stages of joint degeneration

    Crystal chemistry and selected physical properties of inorganic fluorides and oxide-fluorides

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    importance in the development of many new technologies, andare impacting various key points of modern life, that is, energyproduction and storage, microelectronics and photonics,catalysis, automotive, building, etc. Many research fields andapplications are indeed concerned by a better knowledge of therelationships occurring between the structure of suchcompounds and some pertinent physical properties. ThisReview deals with the structural chemistry of solid-stateinorganic fluorides and oxide-fluorides, mostly transitionmetal-based, including rare-earth elements. Such a Review hasnot been published for a long time.1 Articles that recentlyappeared on inorganic fluorinated compounds were mostlyfocused on material science characteristics: morphology, surfacefunctionalization, nanostructuration of the materials andapplications, rather than on the description of characteristicstructural features.2−5 Detailed reviews focused on rare earthbasedinorganic fluorides have also appeared some yearsago..

    Deep Eutectic Solvents (DESs) and Their Applications

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